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Betaine HCl Supplement
Betaine HCl Supplement
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Betaine HCl
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Betaine HCl is a natural source of gastric acidity for improved digestion.
  • Helps compensate for the age-related decrease in gastric acidity.
  • Supports digestion, absorption of nutrients and detoxification, and limits alcohol-related liver damage.
  • Helps reduce the risk of stomach infections (Helicobacter pylori, salmonella, clostridium).
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Optimised stomach

Betaine HCl Supplement - Natural Stomach Acidifier to Improve Digestion

Betaine HCl is a natural stomach acidifier made from betaine, an alkaloid found in foods such as beetroot. It is designed to compensate for the decline in gastric acidity typically seen after the age of 50, thus providing benefits for improving digestion, nutrient absorption and the prevention of gastrointestinal infections. The supplement is enzymatically stabilised (by the presence of proteases) to ensure it remains effective over time.

What does hydrochloric acid do in the stomach?

After food moves down the oesophagus, it enters the stomach, the lining of which immediately secretes hydrochloric acid. This highly acidic fluid is produced (at a rate of around two litres a day) by parietal cells every time we eat. It is strong enough to destroy the vast majority of bacteria that enter the digestive tract along with food.

Its main role, however, is to promote protein digestion by activating pepsin. Secreted by other stomach cells, this digestive enzyme is only effective in highly acidic environments. How is the stomach able to withstand the corrosive effect of hydrochloric acid? Its inner walls are coated with a protective layer of mucus produced by certain stomach cells. When production of this mucus is inadequate, however, the gastric mucosa rapidly erodes, potentially resulting in ulcers or gastritis. If nothing is done to address it, the acid may even perforate the stomach wall, allowing its contents to pass into the abdominal cavity, and cause peritonitis.

What happens, on the other hand, if the stomach fails to produce enough hydrochloric acid?

Pepsin, the active dietary protein-digesting enzyme of the stomach, is no longer activated, marking the start of digestive problems. Hydrochloric acid has four fundamental roles:

  • To break down proteins into essential amino acids and micronutrients through activation of pepsinogen.
  • To stimulate the pancreas and small intestine in order to support the production of digestive enzymes and bile, both of which are essential for carbohydrate and fatty acid digestion.
  • To promote absorption of iron, zinc, magnesium, folic acid and vitamins C and A (1-2).
  • To prevent infections by killing pathogenic bacteria and yeasts present in ingested food (3). Scientists have thus shown that one of the deadliest forms of pathogenic bacteria, E. coli, is inactivated when the stomach is sufficiently acidic (4). Conversely, research has also demonstrated that inadequate levels of acidity are associated with rapid invasion of the colon by microorganisms, leading to a range of uncomfortable gastrointestinal problems (5).

What causes inadequate production of hydrochloric acid (hypochlorhydria)?

Hypochlorhydria, or a lack of hydrochloric acid, is much more widespread than you might think. Normal stomach acidity corresponds to a pH of 1-2 (6). As we age, however, the stomach’s parietal cells produce less hydrochloric acid (7), and our pH rises … In fact, 50% of those over 60 have an inadequate level of stomach acidity. By the age of 85, this proportion rises to almost 80%. What’s more, there are additional factors that can exacerbate the situation:

  • Infection by Helicobacter pylori (8) (one in two of us may be affected, most of us without realising it).
  • Repeated use of antacid medication to treat acid reflux (proton pump inhibitors).
  • Immune system problems such as pernicious anaemia, a disease in which antibodies attack the parietal cells that produce acid.

What are the effects of low stomach acidity?

The effects of inadequate acidity spill over into many of the body’s functions.

  • Inefficient digestion, leading to deficiencies and a general weakening of the body. The decline in acid production results in low levels of activated pepsin. This makes digesting proteins very difficult and causes deficiencies which are damaging to our general health. In addition, undigested proteins acidify the blood, causing alkaline minerals to leach from all over the body, including the bones, a process that plays a key role in the development of osteoporosis.
  • The proliferation of bacteria in the gut. Low gastric acid levels lead to bacterial proliferation in the small intestine, causing numerous digestive problems (9), not least Small Intestinal Bacterial Overgrowth, or SIBO. Sufferers of SIBO complain of bloating, flatulence, belching and abdominal pain. Undigested proteins are also a source of toxins in the gut and may contribute to the onset of other chronic intestinal problems.
  • Problems with absorbing medication. Stomach acidity is a key factor in the dissolution and solubility of a number of drugs.

In addition, a number of health issues are linked to problems with gastric acid production, particularly allergies, asthma and gallstones.

How should you take Betaine HCl?

Betaine HCl should be taken before meals in order to prepare the stomach and facilitate digestion. Take care to chew food properly during the supplementation period. If you’re not sure whether your acidity levels are adequate, you can follow these steps:

  1. Start by taking a tablet of Betaine HCl just before a protein-rich meal.
  2. If you experience some gastric discomfort, you probably do not have a problem producing hydrochloric acid in your stomach. If you feel no such undesirable effect, take two tablets with each protein-containing meal. A dose of two tablets of Betaine HCl delivers the equivalent of 10 mmol of H+ ions, that’s a pH of 1.40 in 250 ml of water.
  3. If you feel no discomfort over the next few days, keep taking this dose. The symptoms associated with low gastric acid production should soon diminish.
  4. When eating lighter meals, adapt the dose.

Betaine HCl can be combined with other supplements available to buy at Supersmart, such as this one for combatting Helicobacter pylori, H. Pylori Fight, if you suspect the presence of this bacteria in your stomach. To maximise protein absorption, it’s also a good idea to supplement with organic aloe vera. Lastly, in order to boost your gut flora – which may have been destabilised by the bacterial proliferation enabled by low gastric acidity - it can be really helpful to add in the excellent probiotic Probio Forte. In terms of phytotherapy, peppermint and gentian are also recognised for their ability to stimulate secretion of hydrochloric acid.

Are there any contraindications?

Hydrochloric acid supplements are not recommended for those suffering from ulcers, nor should they be taken by pregnant women experiencing problems with stomach acid, or those taking antihistamines (H2) or proton pump inhibitors like omeprazole or other generic forms.

The tablets should not be crushed into food. Alcohol should be avoided. Consult a health professional before supplementing if you are taking anti-inflammatory drugs, for example, NSAIDs, aspirin or ibuprofen.

Betaine hydrochloride is a supplement that’s been used for more than a century for naturally restoring gastric acidity and supporting digestion. Betaine is a completely natural, safe substance (10), found in a wide variety of foods such as beetroot, spinach and whole grains. It offers a range of additional benefits:

  • It helps maintain the body’s water and salt levels.
  • It protects cells and their constituents from environmental stress.
  • It helps protect the liver from hepatotoxins such as ethanol or carbon tetrachloride.
  • It has a beneficial effect on hepatic steatosis (fatty liver), painful gallstones and hyperglycaemia.
  • It helps improve brain activity, primarily as a result of its role in the methionine cycle.
  • It enhances physical and athletic performance, due mainly to its ability to increase the body’s levels of nitric oxide.

Buy Betaine HCl to compensate for the decline in gastric acidity.

Daily dose: 4 tablets
Number of doses per pack: 30
Amount per dose
Betaine HCl 2600 mg
Protease 3000 HUT/g 300 mg
Other ingredients: acacia gum
Directions for use
Take 4 tablets a day. Each tablet contains 650mg of betaine HCl and 75mg of protease (225 HUT).
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  1. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a B-carotene dose in humans. Am J Clin Nutr 1996;64:622-626.
  2. Brummer P, Kasanen A. The effect of hydrochloric acid on the indican metabolism in achlorhydria. Acta Medica Scan 1956;155:11-14.
  3. Takumi K, de Jonge R, Havelaar A. Modeling inactivation of Escherichia coli by low pH: application to passage through the stomach of young and elderly people. J. Appl Microbiol 2000 Dec;89(6):935-43.
  4. Sharp GS, Fister HW. The diagnosis and treatment of achlorhydria: ten-year study. J Amer Ger Soc 1967;15:786-791.
  5. Jonathan Wright, MD, The Digestive Theory of Aging, Part I, http://www.tahoma-clinic.com/aging.shtml.
  6. Eley T, Luo FR, Agrawal S, Sanil A, Manning J, Li T, Blackwood-Chirchir A, Bertz R. Phase I Study of the Effect of Gastric Acid Ph Modulators on the Bioavailability of Oral Dasatin. in Healthy Subjects. J Clin Pharmacol. 2009;49:700–709.
  7. Schilcher, H,: Deutshe Apotheker Zeitung 124:1433-1443 (1984) (Brundesanzeiger (Cologne, Germany): Nov. 30, 1985; March 13, 1986.
  8. El-Omar EM, Oien K, El-Nujumi A, Gillen D, Wirz A, Dahill S, Williams C, Ardill JE, McColl KE. Helicobacter Pylori Infection and Chronic Gastric Acid Hyposecretion. Gastroenterology. 1997;113:15–24.
  9. Walker, RI, Owen, RL. Intestinal barriers to bacteria and their toxins. Annu Rev Med. 1990;41:393–400
  10. Betaine Anhydrous for Oral Solution (Cystad., Package Insert) Rare Disease Therapeutics, Inc; Franklin

Synergy packs

Betaine HCl Supplement
Betaine HCl
Natural source of gastric acidity for improved digestion
22.00 €(22.37 US$)
5 1 reviews
Probio Forte Supplement
Probio Forte
Probiotic mix ; 8 billion microorganisms per capsule. In gastroresistant DR Caps™ for optimum efficacy
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Betaine HCl Supplement
Betaine HCl
Natural source of gastric acidity for improved digestion
22.00 €(22.37 US$)
5 1 reviews
H. Pylori Fight Supplement
H. Pylori Fight
The natural treatment for Helicobacter pylori
33.00 €(33.56 US$)
4.5 21 reviews
Pack "Betaine HCl + Helicobacter pylori"
55.00 €(55.93 US$)
Betaine HCl Supplement
Betaine HCl
Natural source of gastric acidity for improved digestion
22.00 €(22.37 US$)
5 1 reviews
Organic Aloe Vera Supplement
Organic Aloe Vera
Relieves the digestive system without irritating
18.85 €29.00 €(19.17 US$)
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