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Welcome Shop by health concern Care of joints, bones and muscles Bone Health + Complete K
Bone Health + Complete K
Bone Health + Complete K Bone Health + Complete K Bone Health + Complete K
Bone Health + Complete K
Care of joints, bones and muscles Customer reviews
52.00 €(57.95 US$) is available
Description
Vitamin K-based formulation
  • Based on the 3 most bioavailable forms of vitamin K.
  • Helps activate certain coagulation factors.
  • May play a role in preventing cardiovascular disease and osteoporosis.
The 100% natural formulation for rebalancing bone modelling and preventing bone loss
  • Helps maintain the structural integrity and biomechanical quality of bones.
  • Supports the bone formation phase and helps reduce the resorption phase.
  • Helps balance bone metabolism.
  • Contains natural ingredients (phytoestrogens) that mimic the action of oestrogens.
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Bone Health

Bone Health is a 100% natural supplement aimed at strengthening the bones. It contains four plant extracts traditionally used for combatting bone loss: Astragalus membranaceus root, Cuscuta chinensis seeds, Eucommia ulmoides leaves and Rehmannia glutinosa root standardised to 2% flavonoids.

Research has shown that these four plants naturally help reduce the activity of osteoclasts (the bone resorption phase) and support that of osteoblasts (the bone formation phase).

Bone Health is the perfect complement to the bone function formulation Super Bone formula, which contains vitamins and minerals.

Who is Bone Health aimed at?

Bone Health is recommended for the following groups of people:

  • Those aged over 40 (bone mass starts to decline by 1%-2% a year at this age).
  • Menopausal women (during the post-menopause decade, bone loss speeds up by 2%-3% a year due to the fall in oestrogen production).
  • Those with a family history of osteoporosis-related fractures.
  • Women who do little or no exercise.
  • Those suffering from inflammatory bowel disease (Crohn’s).

What’s the reason for this bone loss?

Primarily linked to ageing, osteoporosis is a natural process characterised by a decrease in bone mass and bone density. It makes bones more ‘porous’ and vulnerable to fractures from even simple falls. As bone loss does not normally produce any symptoms prior to a fracture, it is known as ‘the silent disease’. But why does this bone loss occur?

Our bones undergo constant remodelling throughout life via a two-fold process:

  • A resorption phase during which specialised cells called ‘osteoclasts’ eat away at existing bone structures. This leads to the development of holes in the bones (called Howship lacunae).
  • A new formation phase during which other specialised cells called ‘osteoblasts’ make new bone structures to compensate for the ‘holes’ and restore bones to a healthy state. Minerals then accumulate in the new matrix to optimise the bones’ mechanical resistance.

This dual process allows the body to be in constant harmony with its environment. In this way, damaged bones are quickly rebuilt and the body is even able to make stronger bones if environmental factors change (such as when we engage in a new physical activity). However, it’s important that this two-fold process remains in balance: if the resorption phase gains the upper hand, the ‘holes’ are never filled in and bones become dangerously fragile. This is exactly what happens in osteoporosis.

A number of factors affect the balance of this bone remodelling (1):

  • Sex hormones. Oestrogens are the main regulators of bone tissue remodelling. They target osteoblasts and are powerful inhibitors of bone resorption by osteoclasts. The fall in oestrogen caused by the menopause leads to an enduring imbalance in bone renewal: gains start to be outweighed by losses and osteoporosis develops rapidly.
  • Mechanical constraints. Bones are able to adapt according to the level of physical restraint to which they’re subjected. When you suddenly stop exercising, following an injury for example, physical stimulation stops, which increases the resorption phase and reduces the rebuilding phase. Physical inactivity is therefore a cause of osteoporosis over the long term.
  • Bone Morphogenetic Proteins (BMPs). These are proteins which promote the bone formation phase.
  • Insulin Growth Factors (IGFs). These stimulate osteoblast activity.
  • Transforming Growth Factor (TGF) . This is a group of messengers that significantly influence the two phases of bone remodelling.
  • Vitamin D. This vitamin plays an essential role in bone renewal: it stimulates intestinal absorption of calcium and phosphate (which are used to mineralise new bones) and inhibits parathormone, a protein that stimulates bone resorption.

What does the supplement Bone Health contain? What makes it so good for supporting bone remodelling?

Bone Health contains a blend of four plant extracts traditionally used for combatting bone loss.

Eucommia ulmoidesleaves

This is one of the most commonly-prescribed natural treatments in China for treating osteoporosis (2-3). According to the theory of traditional Chinese medicine, Eucommia ulmoides (which is also called Du-Zhong in Asia) optimises the health of the kidneys which nourish and support bone tissue.

While modern science has demonstrated the anti-osteoporosis properties of Eucommia ulmoides, the mechanism of action is not yet clear. Several studies have shown that the plant’s non-steroidal polyphenolic lignans (4) behave in the same way as oestrogens. These ‘phytoestrogens’ may also bind to ‘oestrogen receptor alpha’ (5-7), potentially upregulating the activity of a number of genes central to osteoblast function (8).

It is this mechanism which may explain their ability to stimulate the phase of bone formation by osteoblasts (9) and thus increase bone mineral density, without causing any side-effects (10).

Astragalus root

Astragalus is well-known for its adaptogen properties but this traditionally-used plant has other strings to its bow. With a high content of flavonoids, particularly isoflavones (11), it has been used for thousands of years to counteract osteoporosis (12).

Research has shown that it acts on two factors involved in bone remodelling (13-14):

  • It increases levels of TGF-β1, a growth factor which actively supports bone formation. This factor enables the recruitment, differentiation and proliferation of osteoblasts necessary for bone formation (15-16).
  • It also reduces levels of TGF-α, another growth factor that plays an important role in bone resorption and strongly promotes bone destruction by osteoclasts. After the menopause, levels of TGF-β1 fall (17), contributing to the imbalance in bone remodelling.

Scientists believe that the isoflavones in Astragalus also interact with oestrogen receptors. Like oestrogens, they increase the absorption of calcium which is vital for bone remineralisation.

Cuscuta chinensisseeds.

Cuscuta chinensis is a parasitic plant that has been used in traditional medicine for thousands of years for supporting bone function. It is also known as Dodder and Tu-Si-Zi. Its mechanism of action appears to be very similar to that of Astragalus: Cuscuta chinensis also contains a number of flavonoids (18), the most active of which are kaempferol, quercetin, hyperoside, astragalin and lignans (19).

Studies show it supports osteoblast differentiation and proliferation while inhibiting osteoclast activity (20-21).

Extract of Rehmannia root

Rehmannia glutinosa is an edible plant commonly known as Dihuang, used for at least 3000 years in traditional medicine. Modern research has revealed the presence of numerous bioactive compounds including flavonoids and monoterpenoids (22). Catalpol appears to be the most effective of the monoterpenoids (23) for supporting bone function, though the precise mechanism has yet to be established.

Five good reasons to opt for Bone Health

  1. Most of the drugs used for treating osteoporosis (biphosphonates, calcitonin, oestrogens, fluoride, etc) cause problematic side-effects in the long term (osteonecrosis of the jaw, increased risk of certain cancers and several cardiovascular problems) (24-28). There is thus significant demand for natural products that are free from such side-effects.
  2. Recent research shows it’s no coincidence that these four plant extracts are traditionally used to support bone function. They are all rich in phytoestrogens, molecules that mimic oestrogen activity and thus control several factors involved in bone remodelling.
  3. This trademarked blend has been the subject of one in vitro and two in vivo studies. In all three cases, researchers observed a significant increase in biomarkers of bone formation as well as an improvement in resistance to fracture.
  4. Bone Health acts synergistically with vitamins and minerals scientifically recognised as beneficial for bone health. While these substances are the elements needed for bone remineralisation, Bone Health enables the body to choose the right specification and help implement it effectively.
  5. It contains only natural and safe texturing agents – rice flour and acacia fibre.

How and when should Bone Health be taken?

For significant long-term effects, supplementation should continue for a period of several months, at a dose of two capsules a day.

A number of additional measures can be taken:

  • supplementation with vitamin D, with calcium, or with other relevant substances (orthosilicic acid, and BMPs…) ;
  • frequent exposure to sunlight;
  • reducing consumption of caffeinated drinks (as they encourage calcium loss and thus the bone resorption phase);
  • taking up, or returning to, regular exercise (at an appropriate level for your physical condition).

The blend is very well-tolerated and is completely non-toxic.

Updated: February 2019.

Notes

This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.

References

  1. Thomas T., Martin A., Lafage-Proust M.-H. Physiologie du tissu osseux. EMC (Elsevier Masson SAS, Paris), Appareil locomoteur, 14-002-B-10, 2008.
  2. Kawasaki, T., Uezono, K., Nakazawa, Y., 2000. Antihypertensive mechanism of food for specified health use. “Eucommia leaf glycoside” and its clinical application. Journal of Health Science 22, 29–36.
  3. Deyama, T., Nishibe, S., Nakazawa, Y., 2001. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacologica Sinica 22, 1057–1070
  4. Deyama, T., Nishibe, S., Nakazawa, Y., 2001. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacologica Sinica 22, 1057–1070
  5. Zhang, R., Pan, Y.-L., Hu, S.-J., Kong, X.-H., Juan, W., & Mei, Q.-B. (2014). Effects of total lignans from Eucommia ulmoides barks prevent bone loss in vivo and in vitro. Journal of Ethnopharmacology, 155(1), 104–112. doi:10.1016/j.jep.2014.04.031
  6. Yang, X.J., Wo, M.S., Wang, N.L., Chan, S.C., Yao, X.S., 2007. Lignans from the stems of Sambucus williamsii and their effects on osteoblastic UMR106 cells. Journal of Asian Natural Products Research 9, 583–591.
  7. Jiang, M.M., Gao, H., Dai, Y., Zhang, X., Wang, N.L., Yao, X.S., 2009. Phenylpropanoid and lignan derivatives from Antiaris toxicaria and their effects on proliferation and differentiation of an osteoblast-like cell line. Planta Medica 75, 340–345.
  8. Riggs, B.L., Hodgson, S.F., O'Fallon, W.M., Chao, E.Y., Wahner, H.W., Muhs, J.M., Cedel, S.L., Melton III, L.J., 1990. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. New England Journal of Medicine 322, 802–809.
  9. Ha, H., Ho, J., Shin, S., Kim, H., Koo, S., Kim, I.H., Kim, C., 2003. Effects of Eucommiae cortex on osteoblast-like cell proliferation and osteoclast inhibition. Archives of Pharmacal Research 26, 929–936
  10. Zhang, R., Pan, Y.-L., Hu, S.-J., Kong, X.-H., Juan, W., & Mei, Q.-B. (2014). Effects of total lignans from Eucommia ulmoides barks prevent bone loss in vivo and in vitro. Journal of Ethnopharmacology, 155(1), 104–112. doi:10.1016/j.jep.2014.04.031
  11. Zheng Z, Liu D, Song C, Cheng C, Hu Z (1998) Studies on chemical constituents and immunological function activity of hairy root of Astragalus membranaceus. Chin J Biotechnol 14:93–97
  12. Kim, C., Ha, H., Lee, J.H., Kim, J.S., Song, K., and Park, S.W. (2003). Herbal extract prevents bone loss in ovariectomized rats. Arch Pharm Res. 26:917-24.
  13. Qu, Z.H., Yang, Z.C., Chen, L., Lv, Z.D., Yi, M.J., Ran, N. (2012). Inhibition airway remodeling and transforming growth factor-β1/Smad signaling pathway by astragalus extract in asthmatic mice. Int J Mol Med. 2012:564-8
  14. Jung, Koo H., Sohn, E.H., Kim, Y.J., Jang, S.A., Namkoong, S., Chan Kang, S. (2013). Effect of the combinatory mixture of Rubus coreanus Miquel and Astragalus membranaceus Bunge extracts on ovariectomy-induced osteoporosis in mice and anti-RANK signaling effect. J Ethnopharmacol. 2014:951-9.
  15. Wergedal, J.E., Matsuyama, T., and Strone, D.D. (1992). Differentiation of normal human bone cells by transforming growth factor-βand 1,25(OH)2 Vitamin D3. Metabolism. 41:42-48.
  16. Ingram, R.T., Bonde, S.K., Riggs, B.L., and Fitzpatrick, L.A. (1994). Effects of transforming grouth factor beta(TGF beta ) and 1,25 dihydroxyvitamin D3 on the function, cytochemistry and morphology of normal human osteoblast-like cells. Differentiation. 55:153-163.
  17. Ikeda, T., Shigeno, C., Kasai, R., Kohno, H., Ohta, S., Okumura, H., Konishi, J., and Yamamuro, T. (1993). Ovariectomy decreases the mRNA levels of transforming growth factor-beta 1 and increases the mRNA levels of osteocalcin in rat bone in vivo. Biochem Biophys Res Commun. 194:1228-1233
  18. Hou, D.Y., Li, T.C., Yu, B., 2003. Comparative study of volatile oil on Cuscuta 2 species. Journal of Chinese Mass Spectrometry Society 24, 343–345.
  19. Williamson, G., Barron, D., Shimoi, K., Terao, J., 2005. In vitro biological properties of flavonoid conjugates found in vivo. Free Radical Research 39, 457–469.
  20. Yao, C.H., Tsai, H.M., Chen, Y.S., Liu, B.S., 2005. Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin, and Chinese medicine as a bone substitute. Journal of Biomedical Material Research part B Apply Biomaterial 75, 277–288
  21. Yang, L., Chen, Q., Wang, F., Zhang, G., 2011. Antiosteoporotic compounds from seed of Cuscuta chinensis. Journal of Ethnopharmacology 135, 553–560.
  22. Fu, G., Du, X., 2015. Research advance on chemical constituents and pharmacological activities of Rehmannia glutinosa China Medicine and Pharmacy 5, 21-23.
  23. Lai, N., Zhang, J., Ma, X., Wang, B., Miao, X., Wang, Z., Guo, Y., Wang, L., Yao, C., Li, X., Jiang, G., 2015. Regulatory Effect of Catalpol on Th1/Th2 cells in Mice with Bone Loss Induced by Estrogen Deficiency. American journal of reproductive immunology 74, 487-498.
  24. Stevenson, J.C., 2005. Justification for the use of HRT in the long-term prevention of osteoporosis. Maturitas 51, 113–126
  25. Foidart, J.M., Desreux, J., Pintiaux, A., Gompel, A., 2007. Hormone therapy and breast cancer risk. Climacteric 2, 54–61.
  26. Mørch, L.S., Løkkegaard, E., Andreasen, A.H., Krüger-Kjaer, S., Lidegaard, O., 2009. Hormone therapy and ovarian cancer. The Journal of the American Medical Association 302, 298–305.
  27. Khosla, S., Burr, D., Cauley, J., Dempster, D.W., Ebeling, P.R., Felsenberg, D., Gagel, R.F., Gilsanz, V., Guise, T., Koka, S., McCauley, L.K., McGowan, J., McKee, M.D., Mohla, S., Pendrys, D.G., Raisz, L.G., Ruggiero, S.L., Shafer, D.M., Shum, L., Silverman, S.L., Van Poznak, C.H., Watts, N., Woo, S.B., Shane, E., American Society for Bone and Mineral Research, 2007. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. Journal of Bone and Mineral Research 22, 1479–1491.
  28. O'Ryan, F.S., Lo, J.C., 2012. Bisphosphonate-related osteonecrosis of the jaw in patients with oral bisphosphonate exposure: clinical course and outcomes. International Journal of Oral and Maxillofacial Surgery 70, 1844–1853.
CompositionBone Health
Daily dose: 2 vegetarian capsules
Number of doses per pot: 30
Amount per dose
Osteosine™, a patented blend of extracts of Astragalus membranaceus root, Cuscuta chinensis seeds, Eucommia ulmoides leaves, Rehmannia glutinosa root standardised to 2% flavonoids. 250 mg
White rice flour, acacia gum.
Osteosine™, NuLIV science, USA
Directions for useBone Health
Adults. Take 2 capsules a day. Each capsule contains 125mg Osteosine™.
K shaped flower pot with leafy greens

The term vitamin K covers various substances that play a part in activating certain coagulation factors (or ‘Koagulation’ in German). Having reached the lymphatic vessels, vitamin K is taken up by chylomicrons and accumulates in the liver where it participates in the synthesis of four coagulation factors, including factor II (prothrombin) and its conversion into thrombin.

To whom is a vitamin k supplement aimed at?

Scientists at Maastricht University have even demonstrated that many healthy people are lacking in vitamin K and that supplementation may be beneficial for those aged over 40. However, it applies specially to:

  • New-born and premature babies;
  • Elderly individuals with intestinal malabsorption problems or osteoporosis;
  • Pregnant women and breast-fed babies;

Having said that, research by Dr Rhéaume-Bleue has revealed that 80% of Americans are deficient in vitamin K2, potentially leading to brain disorders, cancer, stroke, kidney stones or osteoporosis. Taking Complete K is therefore essential for those with:

  1. Risk of bleeding;
  2. Intestinal malabsorption (Crohn’s or coeliac disease, chronic diarrhoea…);
  3. The elderly;
  4. Osteoporosis, or more generally, women going through the menopause;
  5. Risk of cardiovascular disease and cancer.

What benefits are associated with vitamin k2?

It is now known that vitamin K2 remains active for a long time in the body (up to 72 hours), at very low doses, while being ten times more bioavailable than vitamin K1, and that it acts synergistically with a number of nutrients such as vitamin E and calcium. However, the biological role of vitamin K2 extends still further:

  • It moves calcium into tissues where it needs to be – the bones and teeth. In activating synthesis of osteocalcin, a specific hormone of bone tissue produced by osteoblasts, it ensures mineralisation by capturing and redistributing calcium within the body to the bones and teeth.
  • It therefore reduces osteoporosis-related bone fractures (particularly broken hips).
  • Conversely, it removes calcium from parts of the body where it shouldn’t be, such as the arteries and soft tissues where it can cause hardening.
  • By doing so, it protects such tissues from eventual calcification in the form of atherosclerosis and aortic calcification.
  • And finally, it supports healthy functioning of the renal system by preventing calcium type kidney stones.
  • A study published in the journal ‘Modern Rheumatology’ has also shown that vitamin K2 may improve symptoms of rheumatoid arthritis, while other research suggests it can help maintain normal ATP production in mitochondrial dysfunction such as that related to Parkinson’s disease.

What do studies show about vitamin k?

Up until the last few years, it was thought there was only one form and one active family of vitamin K, represented by vitamin K1 (phytomenadione or phylloquinone). This is the form found primarily in plants and cruciferous green vegetables such as cabbage, parsley, spinach and lettuce. It is fat-soluble and heat-stable but sensitive to light and alkaline environments.

Other forms of vitamin K, essentially vitamin K2, which is divided into two forms – MK4 and MK-7, have recently been the subject of important studies which have highlighted new properties beyond the well-established role in blood clotting mechanism:

  1. The MK-4raction of vitamin K2 is very similar to vitamin K1 which the body is capable of converting into MK-4. However, the latter has a biological half-life of barely an hour, and is therefore not a good supplement to take alone.
  2. The MK-7 fraction, on the other hand, has a half-life of three days, ensuring stable blood concentrations and enabling low doses to be taken with no cumulative effects. Natto is one of the primary sources for extraction. According to the latest studies, MK-7 is proving to be one of the best preventive agents against chronic inflammation which, over the years, can silently damage tissues and contribute to the development of associated conditions such as obesity, cancer and cardiovascular disease (including stroke and heart attack). Indeed, studies have shown that it inhibits pro-inflammatory markers produced by monocytes.

Menaquinones (vitamin K2) are synthesised by bacteria in the intestinal tract, but they are unfortunately totally eliminated in faeces rather than distributed to vessels, bones and various tissues. K2 vitamins are also found in offal, meat, fermented products such as certain cheeses, and especially natto, a traditional Japanese food made from fermented soybeans, which is by far and away the richest source of vitamin K2 but is unfortunately not part of the Western daily diet.

There is also a synthetic form, vitamin K3 (menadione) which is rarely used since it interferes with the cells’ antioxidant defences and can cause oxidation of cell membranes. In babies, it can destroy red blood cells, leading to anaemia.

Those wishing to supplement with vitamin K should therefore do so with both the K1 and K2 forms.

CompositionComplete K
Dose journalière : 1 gélule
Number of doses per pack : 60
Amount per dose
Vitamin K1 (phytonadione) 1 500 mcg
Vitamin K2 MK-4 (menaquinone 4) 1 000 mcg
Vitamin K2 MK-7 [MenaQ7™ (menaquinone 7)] 150 mcg
Other ingredients: Acacia gum, rice flour.
MenaQ7™, NattoPharma ASA, Norway.
Directions for useComplete K
adults. Take one capsule a day.
Attention: If you are taking anticoagulant drugs, consult your therapist before taking this product.

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