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Can you take melatonin after drinking alcohol?

Is it safe to take melatonin after an evening drinking alcohol? Quick update on the interactions between melatonin and alcohol.

Alcohol before night-time

Recap on melatonin, the famous ‘sleep hormone’

Produced naturally by the pineal gland (a small gland in the brain) as daylight fades, melatonin is a neurotransmitter which promotes drowsiness. That’s why it’s often referred to as the sleep hormone.

But melatonin also indirectly controls the time we wake up. This is because the body’s concentration of melatonin gradually diminishes during the night, as that of cortisol increases. It’s at the point that these two concentration curves cross that we wake up. Scientists thus refer to melatonin as have a ‘chronobiotic’ effect, in other words, it plays a role in synchronising our body clock with circadian rhythms.

Melatonin supplements are thus often used by those suffering from sleep problems. These supplements reduce the time it takes to fall asleep as well as the subjective effects of travelling through different time zones (jet lag) (1-3).

Alcohol and melatonin: okay … but best avoided

Though drinking a little alcohol when on a course of melatonin (or taking the odd melatonin tablet after drinking alcohol) will not produce any dramatic effects, mixing alcohol and melatonin is nonetheless not to be recommended.

Alcohol can actually raise or lower melatonin’s effects. Combining them can cause side-effects such as dizziness, bad dreams, daytime drowsiness, breathing difficulties, increased anxiety … In short, it’s best to take melatonin when you have no alcohol in your system or when you haven’t drunk alcohol in the previous few hours (4-6).

If you suffer from sleep problems more generally, stay away from alcohol and psychoactive substances. Despite their potential sedative effects, they tend to impair sleep quality (7-8).

Other substances that may interact with melatonin

Other substances that potentially interact with melatonin include:

  • anticoagulant drugs (additional melatonin can increase the risk of bleeding) ;
  • anti-seizure medication (melatonin can alter their efficacy) ;
  • immune-suppressants (melatonin can interfere with these drugs)
  • and other sleep aids (you can have too much of a good thing).

So you should avoid supplementing with melatonin if you are taking any of these drugs or aids.

Melatonin: dose, duration and contraindications

In terms of dose, a maximum of 2mg/day is generally recommended. You don’t necessarily need to take a tablet every single day.

As for how long to carry on supplementing, it’s advisable - even though there appear to be few long-term side-effects from taking melatonin - to follow a course for several weeks, stopping after two months, for example (9-10), so that you can evaluate the quality of your sleep. Leave a gap of a few weeks between one course and the next. Occasional use as and when necessary may also be beneficial.

Is melatonin suitable for everyone? In several countries, health authorities have taken the view that melatonin supplementation is contraindicated for the following groups of people:

  • pregnant women and nursing mothers, to avoid any risk to the baby’s physical and cognitive development;
  • anyone suffering from inflammatory or auto-immune diseases, epilepsy, mood disorders …

In addition, melatonin supplementation should be discontinued if you experience any of these side-effects:

  • drowsiness;
  • headaches;
  • dizziness;
  • nausea;
  • irritability and personality disorders;
  • confusion ;
  • enuresis (bedwetting).

Which melatonin supplement should you take?

Melatonin in tablet form

Melatonin is usually available in 1mg tablets (that’s the case for Melatonin 1 mg). You can take two tablets a day, reducing the dose to one a day if you find it hard to wake up.

Melatonin in spray form

Melatonin also comes in the form of a water and glycerine sublingual spray. Taking it in this form ensures rapid, effective absorption across oral mucous membranes (try, for example, Melatonin Spray).

Melatonin combined with CBD

In addition, individuals suffering from anxiety and sleep problems often choose to take a combination of melatonin and cannabidiol (CBD), a cannabinoid from hemp that has no psychoactive effects (such as the supplement CBD + Melatonin).

Combined with relaxing plant extracts

Many people also turn to synergistic formulations which combine melatonin with extracts of relaxing plants such as valerian, hawthorn, hop, passiflora and Californian poppy. Together, and working synergistically with melatonin, these plant extracts can help improve quality of life (try, for example, Advanced Sleep Formula).


  1. RALPH, C. L. Melatonin production by extra-pineal tissues. In : Melatonin: Current status and perspectives. Pergamon, 1981. p. 35-46.
  2. REITER, Russel J. The melatonin rhythm: both a clock and a calendar. Experientia, 1993, vol. 49, no 8, p. 654-664.
  3. RAO, Marie L., MÜLLER‐OERLINGHAUSEN, B., MACKERT, A., et al.Blood serotonin, serum melatonin and light therapy in healthy subjects and in patients with nonseasonal depression. Acta Psychiatrica Scandinavica, 1992, vol. 86, no 2, p. 127-132.
  4. https://landmarkrecovery.com/is-it-dangerous-to-mix-melatonin-and-alcohol/..
  5. https://www.healthcentral.com/article/can-i-take-melatonin-with-alcohol
  6. https://drruscio.com/melatonin-and-alcohol/
  7. KURHALUK, Natalia. Alcohol and melatonin. Chronobiology International, 2021, vol. 38, no 6, p. 785-800.
  8. KURHALUK, Natalia et TKACHENKO, Halyna. Melatonin and alcohol-related disorders. Chronobiology international, 2020, vol. 37, no 6, p. 781-803.
  9. https://www.nhs.uk/medicines/melatonin/#:~:text=Melatonin%20takes%20around%201%20to,for%20up%20to%2013%20weeks.
  10. https://www.hopkinsmedicine.org/health/wellness-and-prevention/melatonin-for-sleep-does-it-work


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