Inside each of our cells is a key metabolism enzyme called AMPK (adenosine monophosphate-activated protein kinase) which plays a fundamental role in energy homeostasis and acts as a ‘life span regulator’.
AMPK is expressed in a number of tissues (liver, brain, skeletal muscle) where it works rather like a ‘metabolic master switch’, regulating several intracellular systems. It thus plays a central role in promoting healthy longevity.
As we grow older, activation of cellular AMPK declines. This leads to, amongst others, weight gain - because AMPK determines body fat composition – and therefore predisposes to the diseases associated with excess weight.
AMPK Booster, a body-support formulation
Most Western societies today are facing a significant problem with over-consumption. Eating too many calories impairs vital functions such as healthy uptake of glucose and fat from the blood, and leads to the accumulation of cellular waste and changes to longevity genes. This manifests as undesirable weight gain, diabetes, degenerative diseases and premature death. Few people are able to successfully maintain long-term calorie restriction, and so the identification by scientists of AMPK is indeed welcome news - when activated, this cellular enzyme mimics the beneficial effects of calorie restriction including loss of surplus body fat.
Pre-clinical research has shown that boosting AMPK activity is associated with:
• a 20-30% increase in lifespan ;
• a reduction in lipogenesis (storage of fat, in particular, dangerous abdominal fat) ;
• stimulation of fatty acid oxidation;
• an increase in insulin sensitivity;
• a change in insulin secretion by pancreatic beta cells;
• improved glucose absorption by cells;
• a reduction in cholesterol and triglycerides;
• suppression of chronic inflammation;
• enhanced activation of the SIRT1 enzyme (similar to that conferred by resveratrol) and of the P53 tumour-suppressor gene.
Boosting AMPK naturally
In order to combat the ageing process, it is therefore essential to restore AMPK production and there are various ways of doing this:
• physical exercise, even though benefits are less marked in elderly people;
- Berberine (Berberis vulgaris)
• calorie restriction, or taking substances that mimic it, such as resveratrol or oxaloacetate;
• AMPK Booster, the result of the latest scientific research, which combines three plant extracts able to reactivate this cellular enzyme:
, an isoquinoline alkaloid, scientifically-demonstrated to be one of the best AMPK-activators, which acts on a number of parameters:
it helps balance energy metabolism and control dietary intake;
- Gynostemma pentaphyllum (or jiaogulan)
it regulates glucose uptake, reduces blood sugar levels and improves cell sensitivity to insulin by increasing production of the transporter GLUT4;
it stimulates fatty acid metabolism in the mitochondria, helping to lower LDL-cholesterol and triglycerides.
It therefore plays a crucial role in preventing metabolic disorders such as obesity and type 2 diabetes.
Like metformin, it is well tolerated by the digestive system and does not require a prescription.
Further confirmation of berberine’s AMPK-activating efficacy comes from recent studies that showed it promoted the multimerisation of adiponectin in adipocytes into high molecular weight (HMW) multimers. These have greater metabolic activity and are closely associated with cell insulin sensitivity. Even though berberine inhibits adiponectin expression, its activation of AMPK promotes multimerisation of adiponectin and thus helps reduce obesity and its complications.
, standardised in gypenosides, has also demonstrated AMPK-activating capacity. Used in traditional Asian medicine, this plant is sometimes called the ‘immortality herb’ both because it increases longevity and also has a number of other properties conferring antioxidant, adaptogen, anti-atherosclerotic and blood pressure-lowering effects.
Scientists observed that in activating AMPK, administration of this herb increased fat-burning and cellular glucose uptake. Cell culture experiments revealed that it doubled fat-burning and increased cellular glucose uptake 1.7-fold.
In a pre-clinical trial, obese mice given G. pentaphyllum showed impressive reductions in markers associated with obesity and its related diseases. In a period of eight weeks, researchers noted decreases of:
8.1% in body weight;
10.3% in deep fat;
15.5% in abdominal fat;
18.8% in liver volume;
and 14.2% in cholesterolaemia.
Similarly, obese rats supplemented for just four days showed reductions in triglycerides (33%), total cholesterol (13%), LDL-cholesterol (33%) and post-prandial blood sugar (20 %), compared with controls.
In another study involving diabetic rats, three weeks’ supplementation with G. pentaphyllum resulted in a 35% improvement in glucose tolerance and a reduction in glucose production and glycogen in the liver .
These results show how the activation of AMPK produces huge benefits in reducing circulating sugar and fats.
Human studies have confirmed what most researchers had discovered in laboratory tests: that G. pentaphyllum boosts AMPK activity and offers certain longevity benefits.
- Fisetin, a flavonoid extracted from the plant Buxus sinica
, sends a ‘switch-on’ signal (like epitalon) to longevity transporter genes in a similar way to calorie restriction but without the need to make dietary changes. Some studies have also shown it has anti-cancer and anti-angiogenic effects.
As an AMPK-activator, it inhibits – via a phosphorylation process – the Mtor signalling pathway and incites cell apoptosis in human melanoma.
Restoring AMPK enzyme activity will thus help you to not only recapture a certain youthfulness, but also control you weight in complete safety. When AMPK is activated, cells are thrown into survival mode and stop storing new fat; instead they burn more stored fat – a process similar to that of calorie restriction.
AMPK Booster is thus an innovative formulation that combines the most effective activators – or reactivators – of cellular AMPK and offers multiple benefits :
• it helps extend lifespan by 20-30% as shown in animal studies;
• it lowers blood sugar levels by increasing cellular glucose uptake;
• it inhibits synthesis of surplus fats and increases fat-burning;
• it reduces triglyceride levels in the blood;
• it combats liver degeneration;
• it increases the number of new, healthy mitochondria.
A natural anti-ageing formulation
Boosting the activity of AMPK would seem to be essential, given what we know about its role within the body. Our new product is designed to activate or reactive AMPK via the action of barberry, jiaogulan and boxwood (Buxus sinica). With proven effects, these plant extracts together constitute a natural, effective formulation for supporting the body. AMPK Booster is offered at a dose of two capsules a day, to be taken with lunch and dinner. You may also be interested in two other natural extracts for improving your general state of health and combatting the ageing process: and .
|Daily dose: 3 capsules
Number of doses per pack: 30
|Amount per dose
|Extract of Gynostemma pentaphyllum standardised to 98% gypenosides
|Extract of Berberis vulgaris standardised to 97% berberine
|Extract of Buxus sinica standardised to 98% de fisetin
|Other ingredients: Acacia gum, rice flour.
Directions for useAMPK Booster
Adults. Take two capsules with lunch and one with dinner.
Finding a way of stopping the ageing process has been the stuff of dreams for generations. But now it’s on the way to becoming reality as Australian and American scientists believe they’ve found a way of not just ‘pausing’ the ageing process but ‘rewinding’ it!
Nicotinamide mononucleotide (NMN) is a precursor of NAD+ (nicotinamide adenine nucleotide) and NADH biosynthesis. This new compound should not, however, be confused with nicotinamide riboside (NR) and other substances already on the market even though they may share certain properties, particularly at a genetic level; NMN is significantly more powerful than NR.
Experiment brings hope for counteracting the ageing process
An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases (cancer and type 2 diabetes).
When Professor Sinclair and his colleagues injected this rare substance into two year-old mice, they observed, after just one week’s treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals. According to Dr Nigel Turner, a pharmacologist at the University of New South Wales,: “It’s like a 60 year-old being similar to a 20 year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".
Re-establishing communication between the mitochondria and cell nucleus
The mitochondria are at the heart of the problem. When they stop communicating properly with the cell nucleus, it is almost as if the cells are deprived of their energy source or battery - their nuclei shrink and ageing becomes inevitable.
For Professor David Sinclair, “The ageing process can be compared to a married couple - when they’re young, they communicate well, but over time, that communication breaks down. And just as with a married couple, restoring communication solved the problem”.
This scientist therefore sees the decline in mitochondrial function and communication as a reversible process! He explains that NAD+ is the central pillar of cell communication but that it decreases sharply with age - until now, the only known way of preventing this loss has been through intensive exercise or calorie restriction.
In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact.
The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN’s ability to activate all seven of the SIRT genes involved in extending longevity.
He believes nicotinamide mononucleotide could be a new class of ‘superdrug’ capable of both preventing diseases such as cancer (via inhibition of HIF-1, a molecule that impairs intracellular communication and plays a role in cancer development) and Parkinson's disease, and extending life expectancy to 150 years!
What is NAD+?
Found in all living cells, NAD+ is a coenzyme involved in redox reactions. It consists of two nucleotides linked by their phosphate group. One nucleotide contains an adenine, the other a nicotinamide. It helps enzymes transfer electrons during redox reactions to form ATP and is thus an aid to energy supply. However, levels decline with age - the NAD+ in an older person’s cells will have fallen by more than 50%. The mitochondria then produce less energy and cells age. Fortunately, this process is not irreversible and intercellular energy mechanisms can be restored if levels of NAD+ are increased.
In addition, NAD is an essential cofactor of key longevity enzymes called sirtuins, activating them directly. Sirtuins play a fundamental role in life expectancy as they deactivate particular genes that lead to ageing via inflammatory processes.
Thus the combined fall in sirtuins 1 and 3, and in NAD+, can cause cerebral degeneration, vascular inflammation, fatigue, loss of muscle strength, increased fat stores around the liver and abdomen and insulin resistance leading directly to metabolic syndrome.
All of these processes can be reversed by means of calorie restriction or supplementation with nicotinamide mononucleotide.
Specific benefits for type 2 diabetes
NMN not only helps prolong life expectancy but has also shown promise in treating type 2 diabetes. This degenerative disease is directly linked to over-consumption of fat and calories which overwhelm adaptive metabolic pathways. Mouse studies showed that NMN improved glucose tolerance by restoring NAD+ levels. It enhanced insulin sensitivity in the liver, restored impaired gene expression related to oxidative stress, inflammatory response and the circadian rhythm by activating SIRT1.
At a conference on the biology of ageing organised by the Ellison Medical Foundation, Dr Shin-Ichiro Imai demonstrated that sirtuins are necessary for calorie restriction to be able to improve the activity of orexin, a brain hormone which enhances cells’ sensitivity to insulin and prevents increases in body fat. However sirtuins alone are not enough - cellular NAD+ must also be present for these beneficial processes to work. The problem is, levels of NAD+ decline both with age and as a result of a high-fat diet.
The good news, according to Dr Imai, is that in NMN-treated mice, researchers observed an increase in NAD+ synthesis, suggesting NMN could be a potential treatment for type 2 diabetes.
In addition to this innovative formulation, you may also be interested in other anti-ageing supplements that offer effective and long-lasting protection from the effects of ageing. The potent , for example, is formulated to reactivate AMPK, a key enzyme of metabolism, levels of which decline with age. The complex contains five natural inhibitors of mTOR proteins, inhibition of which may combat premature ageing. You can also benefit from the optimised formulation which combines a selection of natural anti-ageing nutrients.
In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.
CompositionNicotinamide Mononucleotide 125 mg
|Daily serving: 1 capsule
Number of servings per box: 30
|Amount per dose
|Other ingredients: Acacia gum
Directions for useNicotinamide Mononucleotide 125 mg
Adults. Take 1 capsule a day. Each capsule contains 125 mg of nicotinamide mononucleotide.