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Welcome Shop by health concern Immune system, fatigue and infections Organic Turkey Tail
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Pot containing Turkey Tail mushroom supplement
Pot containing Turkey Tail mushroom supplement Pot containing Turkey Tail mushroom supplement
Organic Turkey Tail
Immune system, fatigue and infections
26.00 €(28.37 US$)
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Description
A mushroom that stimulates immunity and combats deviant cells
  • Extracted from the medicinal mushroom Trametes versicolor.
  • Standardised to 50% polysaccharides.
  • Helps boost immune defences.
  • Supports the body’s fight against germs, corrupted cells and oxidation.
  • Widely used in Asia to restore immunity and as an adjunct to chemotherapy/radiotherapy.
  • Wild specimens picked by hand.
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Trametes versicolor mushrooms that grow on wood

Organic Turkey Tail: pro-immunity supplement containing Trametes versicolor

Organic Turkey Tail is a high-quality dietary supplement composed of extract of Turkey Tail. This medicinal mushroom offers high immunostimulant and antioxidant potency.

Though it remains little-known in the West, it is a popular remedy in traditional Chinese and Japanese medicine. It is also used in modern Asian medicine, particularly alongside anti-cancer treatments.

It is the mushroom’s content of the complex carbohydrates polysaccharides and numerous phenolic compounds which are responsible for its considerable efficacy.

Pro-immunity mushroom that resembles a turkey tail

What is Trametes versicolor?

Turkey Tail, or to give its scientific name, Trametes versicolor, is a lignivore mushroom which means it feeds on wood. It usually grows on the trunks of deciduous trees like beeches and birches, in a wide variety of places and in many different climates.

Its common name Turkey Tail comes from its upright shape and graded shades of brown reminiscent of a wild turkey’s tail fan. It is also known as Coriolus versicolor, kawaratake (‘beside-the-river mushroom’ in Japanese) and yun-zhi (‘cloud mushroom’ in Chinese).

A mushroom rich in PSP and PSK polysaccharides

Turkey tail’s powerful immunostimulant, anti-infectious and anti-tumour effects are due to its many nutrients (1-2). In particular, it has a wide range of polysaccharides. These natural carbohydrates, formed from many smaller simple sugars or monosaccharides, are known for their numerous health benefits.

More specifically, Turkey Tail contains:

  • polysaccharide-peptides (PSP). These long-chain sugars are able to stimulate macrophage and T lymphocyte activity (3) and are also thought to have anti-cancer properties. (4) ;
  • and polysaccharide-K or Krestin (PSK). These complex carbohydrates have been used for more than 30 years as a chemotherapy agent in several Asian countries (5).

What benefits does the supplement Organic Turkey Tail offer?

It helps improve the immune response

First and foremost, Organic Turkey Tail helps boost the body’s immune response.

The polysaccharides in the mushroom Trametes versicolor are known to be effective at activating immune cells. (6) These compounds, referred to as ‘biological response modifiers’, also act by improving the expression of cytokines and chemokines(7-8).

Stimulating immune function naturally increases the body’s protection by making it more resistant to pathogens.

Turkey Tail: effective against infection

Turkey Tail also acts directly against various aggressors such as viruses and bacteria. One study noted its potential as an anti-influenza and anti-herpes agent, and even attributed it with a ‘high therapeutic index’. (9)

This mushroom is also useful in fighting multiple bacteria(10). Let’s not forget that antibiotics, the drugs prescribed for eliminating or limiting bacteria, are themselves often extracts of medicinal fungi.

The polysaccharide-peptides in Trametes versicolor are, amongst others, able to eliminate harmful gut bacteria and thus play a genuine prebiotic role in the body. (11-12) This ability to regulate intestinal microbiota further contributes to this mushroom’s immunomodulatory power. (13)

A mushroom with recognised anti-tumour properties

In Asia, turkey tail is regularly used as a preventive substance and adjunct treatment for several types of cancer. (14-16) A Chinese study of more than 4000 subjects observed positive effects on overall survival and quality of life of cancer patients. (17)

Taking Turkey Tail may significantly increase patient survival, particularly in those with breast, stomach or colon cancer undergoing chemotherapy. (18-19). This mushroom also has recognised therapeutic potential for cervical, uterine and pancreatic cancer as well as leukaemia and malignant lymphoma. (20-21)

Meanwhile, an American study examining the anti-cancer properties of Trametes versicolor found its polysaccharide components to offer benefits as an adjuvant cancer therapy, as part of an overall treatment and secondary prevention strategy. (22)

Turkey tail’s anti-tumour properties are due to several factors:

  • its PSPs improve the ability of T lymphocytes, key immune response cells, to penetrate tumours(23) ;
  • the complex carbohydrates in Coriolus versicoloraccelerate the rate of apoptosis, ie, the elimination of cancer cells (without damaging healthy cells) (24-25) ;
  • as we know, cancer stem cells represent the tiny proportion of cells that survive anti-cancer treatment. If they spread, they can boost tumour growth. polysaccharide-peptides have an ability to combat cancer stem cells, thus inhibiting the formation and spread of tumours. This chemo-preventive property of orally-administered PSPs was revealed in a study on prostate cancer (26) ;
  • these polysaccharides also counteract the fall in white cell numbers caused by cyclophosphamide (a medication used in the treatment of various cancers) (27) ;
  • anti-cancer therapy reduces the body’s immune defences in general; taking Turkey Tail will help restore healthy immunity. (28)

A powerful antioxidant, rich in phenolic compounds

Lastly, Organic Turkey Tail also helps to combat oxidative stress. As we know, this oxidation process unleashes a flood of free radicals in the body, which result in cellular ageing and can lead to chronic inflammation. Turkey tail, a potent antioxidant, counteracts this damage. (29)

This mushroom is in fact a rich natural source of antioxidants, containing numerous phenolic compounds: one study revealed that the phenol-acids in an aqueous extract of turkey tail helped to, amongst others, inhibit DPPH and OH free radicals, as well as acetylcholinesterase (AchE). (30) Among the other phenolic compounds found in Turkey Tail are flavonoids, the well-known and highly-effective antioxidants (31-32), not forgetting its high content of terpenoids or terpenes, another family of antioxidant metabolites. (33-34)

Finally, the results of a 2015 study suggest that extract of Trametes versicolor may also have anti-genotoxic properties – in other words, its components may be able to directly protect a cell’s genome. (35)

Contraindications for takingOrganic Turkey Tail

As a precaution, we recommend that anyone suffering from an auto-immune disease, or who is either awaiting or has undergone an organ transplant should not supplement with turkey tail.

In addition, anyone suffering from cancer should first consult their doctor to make sure that taking this supplement is compatible with their ongoing anti-cancer treatment.

Some additional, synergistic supplements

Other effective medicinal mushrooms

If you’d like to benefit from other pro-immunity medicinal mushroom supplements, we’d draw your attention to one of our great classics: AHCC (Active Hexose Correlated Compound), a powerful immunostimulant extract of shiitake.

For a broader range of mushrooms, we’d recommend Organic MycoComplex. This supplement contains no fewer than 7 different mushroom (reishi, chaga, cordyceps, etc.) It too provides valuable support in stimulating your immune system, as well as relieving fatigue.

The immunostimulant power of colostrum

Still on the subject of immunity, we couldn’t possibly end without mentioning colostrum. This natural substance is the first form of mother’s milk and is incredibly rich in antibodies and essential nutrients. You can benefit from its many properties by starting a course of Colostrum supplements.

Further enhance your fight against abnormal cells

And if you’re particularly interested in combatting deviant cells, we recommend combining Organic Turkey Tail supplementation with Saikosaponin A. Saikosaponin A is an anti-viral and anti-cancer substance derived from the herbaceous plant Bupleurum falcatum. A number of studies suggest it helps to prevent tumours and encourage their regression. (36-37)

Composition
Daily dose: 2 tablets
Number of doses per pack: 30

Amount
per dose

Hand-picked wild extract of wild Trametes versicolor standardised to 50% polysaccharides 1 000 mg
Other ingredients: acacia gum.
Directions for use
Adults. Take 2 tablets a day.
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References
  1. Barros AB, Ferrão J, Fernandes T. A safety assessment of Coriolus versicolor biomass as a food supplement. Food Nutr Res. 2016;60:29953. Published 2016 Mar 10.
  2. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014;13(1):32‐44.
  3. Ng TB (1998). "A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae)". Gen Pharmacol. 30 (1): 1–4.
  4. Abba Kastin (2013-01-26). Handbook of Biologically Active Peptides. Academic Press. pp. 180–. ISBN 978-0-12-385096-6.
  5. Kinoshita J, Fushida S, Harada S, et al. PSK enhances the efficacy of docetaxel in human gastric cancer cells through inhibition of nuclear factor-kappaB activation and survivin expression. Int J Oncol. 2010;36(3):593‐600.
  6. Chang Y, Zhang M, Jiang Y, et al. Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China. Discov Med. 2017;23(127):207–219.
  7. Chang Y, Zhang M, Jiang Y, et al. Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China. Discov Med. 2017;23(127):207–219.
  8. Ng TB. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmacol. 1998;30(1):1‐4.
  9. Krupodorova T, Rybalko S, Barshteyn V. Antiviral activity of Basidiomycete mycelia against influenza type A (serotype H1N1) and herpes simplex virus type 2 in cell culture. Virol Sin. 2014;29(5):284‐290.
  10. Barros AB, Ferrão J, Fernandes T. A safety assessment of Coriolus versicolor biomass as a food supplement. Food Nutr Res. 2016;60:29953. Published 2016 Mar 10.
  11. Pallav K, Dowd SE, Villafuerte J, et al. Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial. Gut Microbes. 2014;5(4):458‐467.
  12. Yu ZT, Liu B, Mukherjee P, Newburg DS. Trametes versicolor extract modifies human fecal microbiota composition in vitro. Plant Foods Hum Nutr. 2013;68(2):107‐112.
  13. Jayachandran M, Xiao J, Xu B. A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota. Int J Mol Sci. 2017;18(9):1934. Published 2017 Sep 8.
  14. Kinoshita J, Fushida S, Harada S, et al. PSK enhances the efficacy of docetaxel in human gastric cancer cells through inhibition of nuclear factor-kappaB activation and survivin expression. Int J Oncol. 2010;36(3):593‐600.
  15. Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev VL. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget. 2018;9(49):29259‐29274. Published 2018 Jun 26.
  16. Chu KK, Ho SS, Chow AH. Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values. J Clin Pharmacol. 2002;42(9):976–984.
  17. Zhong L, Yan P, Lam WC, Yao L, Bian Z. Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2019;10:703. Published 2019 Jul 3.
  18. Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov. 2012;6(1):78–87.
  19. Ng TB. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmacol. 1998;30(1):1‐4.
  20. Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev VL. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget. 2018;9(49):29259‐29274. Published 2018 Jun 26.
  21. Patel S, Goyal A. Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech. 2012;2(1):1‐15.
  22. Standish LJ, Wenner CA, Sweet ES, et al. Trametes versicolor mushroom immune therapy in breast cancer. J Soc Integr Oncol. 2008;6(3):122–128.
  23. Chang Y, Zhang M, Jiang Y, et al. Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China. Discov Med. 2017;23(127):207–219.
  24. Patel S, Goyal A. Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech. 2012;2(1):1‐15.
  25. Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev VL. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget. 2018;9(49):29259‐29274. Published 2018 Jun 26.
  26. Luk SU, Lee TK, Liu J, et al. Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population [published correction appears in PLoS One. 2011;6(6). doi:10.1371/annotation/0f6309be-936c-4974-97bf-ed3a98289cd9] [published correction appears in PLoS One. 2011;6(6).
  27. Ng TB. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmacol. 1998;30(1):1‐4.
  28. Saleh MH, Rashedi I, Keating A. Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide. Front Immunol. 2017;8:1087. Published 2017 Sep 6.
  29. Barros AB, Ferrão J, Fernandes T. A safety assessment of Coriolus versicolor biomass as a food supplement. Food Nutr Res. 2016;60:29953. Published 2016 Mar 10.
  30. Janjušević L, Karaman M, Šibul F, et al. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. J Enzyme Inhib Med Chem. 2017;32(1):355‐362.
  31. Janjušević L, Karaman M, Šibul F, et al. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. J Enzyme Inhib Med Chem. 2017;32(1):355‐362.
  32. Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:e47. Published 2016 Dec 29.
  33. Janjušević L, Karaman M, Šibul F, et al. The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents. J Enzyme Inhib Med Chem. 2017;32(1):355‐362.
  34. Grassmann J. Terpenoids as plant antioxidants. Vitam Horm. 2005;72:505‐535.
  35. Knežević A, Živković L, Stajić M, Vukojević J, Milovanović I, Spremo-Potparević B. Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells. ScientificWorldJournal. 2015;2015:146378.
  36. Yano H, Mizoguchi A, Fukuda K, et al. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res. 1994;54(2):448‐454.
  37. Sun Y, Cai TT, Zhou XB, Xu Q. Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis. Int Immunopharmacol. 2009;9(7-8):978‐983.

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