Finding a way of stopping the ageing process has been the stuff of dreams for generations. But now it's on the way to becoming reality as Australian and American scientists believe they've found a way of not just pausing the ageing process but rewinding it. Nicotinamide mononucleotide (NMN) is a precursor of NAD+ (nicotinamide adenine nucleotide) and NADH biosynthesis. This new compound should not, however, be confused with nicotinamide riboside (NR) and other substances already on the market even though they may share certain properties, particularly at a genetic level; NMN is significantly more powerful than NR.
What are the benefits associated to Nicotinamide Monocleotide?
NMN not only helps prolong life expectancy but has also shown promise in treating type 2 diabetes. This degenerative disease is directly linked to over-consumption of fat and calories which overwhelm adaptive metabolic pathways. Mouse studies showed that NMN improved glucose tolerance by restoring NAD+ levels. It enhanced insulin sensitivity in the liver, restored impaired gene expression related to oxidative stress, inflammatory response and the circadian rhythm by activating SIRT1.
At a conference on the biology of ageing organised by the Ellison Medical Foundation, Dr Shin-Ichiro Imai demonstrated that sirtuins are necessary for calorie restriction to be able to improve the activity of orexin, a brain hormone which enhances cells' sensitivity to insulin and prevents increases in body fat. However sirtuins alone are not enough - cellular NAD+ must also be present for these beneficial processes to work. The problem is, levels of NAD+ decline both with age and as a result of a high-fat diet. The good news, according to Dr Imai, is that in NMN-treated mice, researchers observed an increase in NAD+ synthesis, suggesting NMN could be a potential treatment for type 2 diabetes.
What is NAD+?
Found in all living cells, NAD+ is a coenzyme involved in redox reactions. It consists of two nucleotides linked by their phosphate group. One nucleotide contains an adenine, the other a nicotinamide. It helps enzymes transfer electrons during redox reactions to form ATP and is thus an aid to energy supply. However, levels decline with age - the NAD+ in an older person's cells will have fallen by more than 50%. The mitochondria then produce less energy and cells age. Fortunately, this process is not irreversible and intercellular energy mechanisms can be restored if levels of NAD+ are increased. In addition, NAD is an essential cofactor of key longevity enzymes called sirtuins, activating them directly. Sirtuins play a fundamental role in life expectancy as they deactivate particular genes that lead to ageing via inflammatory processes. Thus the combined fall in sirtuins 1 and 3, and in NAD+, can cause cerebral degeneration, vascular inflammation, fatigue, loss of muscle strength, increased fat stores around the liver and abdomen and insulin resistance leading directly to metabolic syndrome. All of these processes can be reversed by means of calorie restriction or supplementation with nicotinamide mononucleotide.
The mitochondria are at the heart of the problem. When they stop communicating properly with the cell nucleus, it is almost as if the cells are deprived of their energy source or battery - their nuclei shrink and ageing becomes inevitable. For Professor David Sinclair, “The ageing process can be compared to a married couple - when they're young, they communicate well, but over time, that communication breaks down. And just as with a married couple, restoring communication solved the problem”. This scientist therefore sees the decline in mitochondrial function and communication as a reversible process. He explains that NAD+ is the central pillar of cell communication but that it decreases sharply with age - until now, the only known way of preventing this loss has been through intensive exercise or calorie restriction.
What do studies show about Nicotinamide Mononucleotide?
An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases (cancer and type 2 diabetes). When Professor Sinclair and his colleagues injected this rare substance into two year-old mice, they observed, after just one week's treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals. According to Dr Nigel Turner, a pharmacologist at the University of New South Wales,: “It's like a 60 year-old being similar to a 20 year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".
In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact. The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN's ability to activate all seven of the SIRT genes involved in extending longevity. He believes nicotinamide mononucleotide could be a new class of superdrug capable of both preventing diseases such as cancer (via inhibition of HIF-1, a molecule that impairs intracellular communication and plays a role in cancer development) and Parkinson's disease, and extending life expectancy to 150 years. In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.
In addition to this innovative formulation, you may also be interested in other anti-ageing supplements that offer effective and long-lasting protection from the effects of ageing. The potent , for example, is formulated to reactivate AMPK, a key enzyme of metabolism, levels of which decline with age. The complex contains five natural inhibitors of mTOR proteins, inhibition of which may combat premature ageing. You can also benefit from the optimised formulation which combines a selection of natural anti-ageing nutrients.
CompositionNicotinamide Mononucleotide 125 mg
|Daily serving: 1 capsule
Number of servings per box: 30
|Amount per dose
|Other ingredients: Acacia gum
Directions for useNicotinamide Mononucleotide 125 mg
Adults. Take 1 capsule a day. Each capsule contains 125 mg of nicotinamide mononucleotide.
Wild Amazonian Formula is a clever mix of five wild plants from the Amazon designed to stimulate the immune system and develop the body’s ability to self-heal. Each of these medicinal plants has been carefully selected for its immune-stimulant and anti-proliferative properties. They are all hand-picked from the open-air botanical garden that is the Amazon rainforest.
Who is Wild Amazonian Formula aimed at?
This exceptional formulation is primarily for people aged over 50. These individuals’ immune systems are generally weaker and slower to respond to infections and abnormal cellular events than those of younger people.
It is equally suitable for people whose health has been compromised by adverse factors such as diabetes, cardiovascular problems, chronic stress or chemotherapy, as well as anyone who wants to minimise their risk of all kinds of infection.
In short, these are the four benefits offered by our formula:
- It stimulates the immune system and optimises the body’s natural self-healing mechanisms.
- It increases its resistance to adverse influences.
- It produces a general tonic effect, especially following an illness or short-term health problem.
- It combats stress, infections, fatigue and inflammation.
What is in Wild Amazonian Formula?
The Amazon rainforest is an extraordinary source of rare plant species which possess amazing therapeutic properties. SuperSmart has carefully selected the best of them to produce an unprecedented synergistic formula. Three criteria have been applied in making our selection: the plants’ empirical use, their clear, scientifically-demonstrated physiological effects, and their synergistic power.
- Cat’s claw (Uncaria Tomentosa). This is a creeper native to the Amazon basin, much-prized by the indigenous population for its immune-stimulant properties and popularised as a result of the many studies conducted on it in recent years. It plays an important role in regulating programmed cell death, the process which makes abnormal cells ‘commit suicide’. It is its high content of sterol compounds (beta-sitosterol, stigmasterol, campesterol), tannins and procyanidins that’s probably responsible for these well-documented properties. Cat’s claw also helps improve immune response, fight inflammation, boost the antioxidant system and repair damaged DNA (1-4). One clinical trial of 12 healthy subjects demonstrated its protective effect against mutations to DNA (5).
- Suma root (Pfaffia paniculata). Also known as ‘Brazilian ginseng’, suma is an adaptogen plant from the Amazon basin. It has long been used by Olympic athletes to help build muscle and boost endurance, without the unwelcome side-effects of steroids. This effect is primarily linked to its high beta-ecdysterone content, though it also contains saponins, glycosides and other compounds which enable it to slow down the proliferation of abnormal cells and generally optimise the immune system (6-8).
- Inner bark of Lapacho (Pau d’arco). Lapacho has traditionally been used to fight infection of all kinds and to combat abnormal cell processes. Today, it is popular with Brazilians for fighting infections of the respiratory tract and skin, gastroenteritis, and cystitis. Scientists have identified two active ingredients responsible for these positive effects on cellular health and anti-proliferative properties: lapachol and beta-lapachone. They are both powerful, natural anti-inflammatories but lapacho’s efficacy is due more to the synergy created between all its compounds (9-13).
- Graviola leaves (corossolier). This is a tropical Amazonian plant used in traditional medicine for its anti-proliferative properties. A number of studies (14-17) have shown that graviola is associated with optimising mechanisms that stem the development of abnormal cell processes: inducing programmed cell death, selective inhibition, regulating receptors of growth factors … It is the plant’s high alkaloid content, particularly reticulin and coreximine, which is responsible for this exceptional property. Graviola offers other benefits too: it contains enzymatic antioxidants such as catalase and superoxide dismutase, both of which combat oxidative stress …
- Mullaca (Physallis angluata). In folk-medicine, this is used to treat various problems such as rheumatism and malaria. But this Amazon ground-cherry offers much more besides: researchers have demonstrated its ability to inhibit the growth of various abnormal cells, combat inflammation and positively modulate the immune response. In this case, it’s the plant’s richness in physalins – natural steroids with powerful anti-proliferative effects – that’s responsible (18). It also contains phytosterols that have antioxidant properties and positive effects on cardiovascular health.
What effects can you expect to see from taking Wild Amazonian Formula?
The natural plant extracts in Wild Amazonian Formula are well-known to tribes of the Amazon rainforest, particularly the Ashaninka and Campo who believe they affect both mind and body. They have been used in Amazonia for thousands of years. Given that traditional medicine rarely ‘gets it wrong’, thousands of researchers have endeavoured to scientifically test the virtues attributed to these plants. With a certain amount of success: the anti-inflammatory, immune-stimulant and anti-proliferative properties of these plants have indeed been demonstrated and explained in a laboratory setting.
Well-managed combination of these plants can help ward off infections and relieve problems often held in check by conventional medicine. It can, above all, help to stimulate the immune system through several distinct mechanisms:
- Protecting cells against oxidants known to damage cell organelles, membranes and DNA.
- Disrupting replication of viruses and thus preventing their progress within the body.
- Stimulating the interleukin-1 group of cytokines which facilitate transmission of white cells to infection sites.
- Fighting inflammation by inhibiting the production of ‘pro-inflammatory’ prostaglandins and suppressing the activity of TNF, a cytokine involved in chronic inflammation.
- Improving cell oxygenation.
- Repairing errors and mutations to DNA .
- Slowing down or inhibiting abnormal cell proliferation.
5 good reasons to start a course of Wild Amazonian Formula now
- The plants selected are all wild-growing species and are hand-picked. They are therefore much more active than their cultivated equivalents (because they’re subject to different natural stresses) and are completely uncontaminated by pesticides.
- Large-scale scientific studies support the use of the five plants contained in this formula.
- These plants have been used for thousands of years because of their high content of exceptional micronutrients.
- They all help stimulate the immune system and optimise the body’s natural self-healing mechanisms.
- With different mechanisms of action, they offer maximum synergy.
How should you take Amazonian Formula? Are there any contraindications?
Wild Amazonian Formula is not recommended for those suffering from auto-immune diseases because in these individuals, stimulating the immune system threatens, rather than protects, the body. In addition, some of the plants used, particularly mullaca, can produce a mild hypotensive and anti-coagulant effect.
To optimise supplementation, it’s advisable to follow the recommendations below:
- Make sure you get the right amount of sleep for your needs (7 hours a night is often the minimum required).
- Don’t smoke and try to use household products that contain a minimum of chemicals.
- Always wash your fruit and vegetables or make sure you choose organic varieties.
- Take regular, moderate exercise.
- Eat a healthy diet, prioritising immune-stimulant foods such as mushrooms, garlic, onions and shallots.
Wild Amazonian Formula can be combined with Reishi extract or Green Propolis to maximise its effects on immunity, or with Nicotinamide Mononucleotide 125 mg to add powerful anti-ageing effects.
To prevent winter infections, it’s best to begin a six-month course of supplementation in the autumn. In all other cases, it can be continued for longer.
CompositionWild Amazonian Formula
|Daily dose: 4 capsules
Number of doses per pack: 30
|Amount per dose
|4:1 extract of suma root (Pfaffia paniculata)
||400 mg *
|4:1 extract of cat’s claw bark (Uncaria tomentosa)
||400 mg *
|4:1 extract of graviola leaves (Annona muricata)
||400 mg *
|4:1 extract of pau d’arco (Tabebuia impetiginosa)
||300 mg *
|Mullaca powder (Physalis angulata)
||300 mg *
|Other ingredients: acacia gum, white rice flour.
*Wild-growing, hand-picked plants.
Directions for useWild Amazonian Formula
Adults. Take 2 capsules twice a day.