Allergies are on the increase worldwide. To alleviate their troublesome symptoms, sufferers are increasingly turning to natural antihistamines.
Allergy, which has become a real public health problem, is an inappropriate and excessive reaction by the immune system.
When it comes into contact with a foreign substance (the allergen, such as pollen or certain foods), the body goes into overdrive, believing it is recognising a harmful intruder, even though the substance is harmless.
The B lymphocytes then produce specific antibodies called IgE, which are responsible for recognising future intruders of the same type and neutralising them.
IgE antibodies are linked to large reserve cells called mast cells, which are particularly rich in histamine, a protective molecule usually used by the body in response to infection or injury.
With each new encounter with the allergen (even if the allergen is harmless), the IgE antibodies sound the alarm and the associated mast cells release their massive reserve of histamine, causing the unpleasant symptoms of allergy.
Once released, histamine molecules bind to 4 different receptors (H1, H2, H3 and H4) located on cells in the blood vessels, stomach, brain and immune cells.
This triggers various symptoms, such as vasodilation of the vessels (redness and swelling), contraction of the bronchi (coughing, breathing problems), itching, etc.
One of the best ways of interrupting this reaction, and limiting its consequences, is to prevent histamines from binding to their receptors in one way or another.
Medicated antihistamines are used for this purpose:
Natural antihistamines can also be used, although they are not a complete substitute for synthetic antihistamines, particularly in the case of severe symptoms. Instead, they are used for mild allergies such as allergic rhinitis (hay fever).
Quercetin is undoubtedly the most powerful potential natural antihistamine known to date.
Quercetin is a flavonoid polyphenol found fairly easily in fruit and vegetables, and is unintentionally consumed in quantities of between 5 and 40 mg a day.
Its efficacy has been compared in several studies to certain antihistamine drugs (1).
Unlike the latter, quercetin does not directly prevent histamines from binding to their various receptors, but it does disrupt their release by mast cells.
Other mechanisms of action have been suggested, such as reducing the messengers that encourage the inflammatory response, including interleukin 4.
Its potential ability to relieve both the symptoms of allergic rhinitis (2-3) (sneezing attacks, itching, itchy eyes, etc.) and those of atopic dermatitis (4-5) is regularly tested in the laboratory.
Two studies (6-7) conducted under natural conditions (in vivo) and focusing on both the early phase (immediate hypersensitivity) and the late phase (inflammatory reaction), suggest that it is useful for attenuating allergic reactions.
Natural sources of quercetin include, in descending order:
As you can see, it's difficult to consume large quantities of quercetin through the diet, but several clinical and epidemiological studies have nonetheless established a link between high and regular consumption of quercetin-rich foods and the alleviation of troublesome allergic symptoms.
Note that heat does not alter quercetin, but cooking kale in water causes losses of up to 30%.
In the event of a sudden allergic reaction, quercetin food supplements are obviously more reliable, as it's not always easy to eat capers or onions at the recommended quercetin intake level: 200 to 1,000 mg per day.
Quercetin supplements are available without a prescription.
Ideally, choose an anhydrous quercetin supplement, which has the advantage of containing virtually no water, meaning you pay only for the active form of the compound.
Anhydrous quercetin is also reputed to be more stable and more bioavailable (this is the case with Super Quercetin, which contains a patented form of quercetin, named QU995™, derived from exclusive extraction and purification processes, guaranteed to be free of heavy metals and with a 170% improvement in bioavailability compared to the quercetin usually on the market) (8).
Quercetin is undoubtedly the leading antihistamine, but other natural compounds are close behind.
Finally, you should be aware that several formulas dedicated to allergic phenomena bring together powerful, potential natural antihistamines, or at least those that act together synergistically and are the safest.
This is particularly true of Aller Fight, a very popular blend containing bromelain, spirulina, astragalus root extract, petasin and maritime pine proanthocyanidins. This formula is specially designed to help regulate the immune defence system against allergens, as well as supporting general well-being and cardiovascular and respiratory health.
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