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Probiotic Bacillus coagulans
Probiotic Bacillus coagulans
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Bacillus Coagulans Probiotic
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Description
Bacillus coagulans, a highly-resistant spore-forming probiotic for intestinal balance
  • Spore-forming bacterium with broad-spectrum activity, which helps to maintain gut microbiota balance.
  • Survives the hostile conditions of the digestive tract (stomach acids, bile salts …) for optimal delivery to the small intestine.
  • Focus of a number of promising studies on intestinal comfort, oral health and modulation of immunity.
  • Studies suggest this probiotic supports production of compounds that inhibit the growth of pathogenic bacteria (coagulin, lactosporin...)
  • 4 billion microorganisms per daily dose.
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Woman taking a probiotic for her gut

Bacillus Coagulans Probiotic – Highly-resistant microbiotic strain

Bacillus Coagulans Probiotic is a probiotic dietary supplement containing at least 2 billion Bacillus coagulans microorganisms per capsule.

With characteristics of both lactobacillus and bacillus, this allochtonous bacteria offers robust resistance to the harshest environmental conditions (including the acidity of gastric secretions), ensuring it reaches the gut completely intact. It thus represents a major hope in research, particularly in terms of combatting intestinal function disorders.

This supplement is thus part of our Digestion and oro-gastrointestinal health category.

Bacillus coagulans: a remarkable probiotic

First isolated in 1932, Bacillus coagulans is a rod-shaped, Gram positive bacterium measuring on average 0.9 μm x 4.0 μm, able to survive in both aerobic and anaerobic (oxygen-deprived) conditions. Though not naturally present in gut flora, it is able to colonise there via the consumption of fruit, vegetables and soil products (1).

Though now classed as a Bacillus, its taxonomy has long been the subject of debate. It used to be more commonly known as Lactobacillus sporogenes, considered a lactobacillus because of its ability to produce lactic acid. But due to the formation of spores in its cytoplasm, absent in lactobacilli and bifidobacteria, scientists finally settled on its classification as a bacillus.

Protected by natural encapsulation, B. coagulans is not impaired by high temperatures, drying, osmolarity or ambient pH changes, enabling it tobypass hydrochloric acid in the stomach, pepsin, pancreatin, ions, digestive enzymes, bile and mucin. An estimated 85% of the spores therefore reach the gut (2), where they are able to ‘germinate’ and proliferate in the intestinal tract as rapidly as 4-6 hours after oral administration.

According to the latest research findings, spore-forming probiotics such as Bacillus coagulans may beneficially affect host health in a number of ways: by modulating composition of the gut microbiota, maintaining immune homeostasis, synthesising digestive enzymes and producing antimicrobial bacteriocins.

What are the benefits offered by Bacillus Coagulans Probiotic?

  • Significant support for irritable bowel syndrome. Several studies have analysed the effects of coagulans in alleviating symptoms of IBS. One randomised, double-blind study reported improved tolerance to abdominal pain, smoother intestinal transit and a reduction in associated anxiety (3).
  • Support during antibiotic treatment. Repeated or prolonged use of antibiotics tends to significantly destabilise the composition of microbial flora by disrupting the balance between beneficial and pathogenic bacteria. Referred to as ‘dysbiosis’, this often manifests in changes in intestinal transit. One study of subjects suffering from acute diarrhoea and abdominal discomfort showed a marked improvement in quality of life following supplementation with coagulans (LBSC strain) (4).
  • A boost for slow transit, or Lazy Bowel Syndrome. In a study of people suffering from functional constipation, coagulans Unique IS-2 showed significant efficacy. At the end of the trial, 98% of subjects receiving the probiotic had normal stools, compared with 74% in the placebo group. There was also a reduction in complaints affecting incomplete evacuation, painful defecation and abdominal spasms (5).
  • A potential adjunct treatment for gynaecological infections. Supplementation with coagulans was offered to 40 women diagnosed with bacterial vaginosis, often resistant to conventional antimicrobial treatment, alongside antibiotics. Positive responses to this treatment were almost double those of a control group (6).
  • Modulation of immune processes. Coagulans appears to affect the immune system in various ways. Its spores release bactericides (including coagulin and lactosporin), lactic acid and short-chain fatty acids such as butyric acid, that can block the path of opportunistic microorganisms (7). A number of studies also suggest it mediates the response of T lymphocytes to certain viral infections of the respiratory tract and inhibits the release of TNF-α, serum amyloid A and fibrinogen in arthritic rats (8-9).
  • Potential applications for oral health. Coagulans may combat the cariogenic (tooth decay-promoting) effects of biofilm microbes. It creates an acid, anaerobic environment which is unfavourable to pathogenic strains such as Streptococcus mutans, but favourable to good lactic bacteria (10).

Bacillus coagulans and Bacillus subtilis: how do they differ?

Bacillus coagulans and Bacillus subtilis are part of the same Bacillaceae family and are both spore-forming. They differ mainly in their endospore location (terminal in B. coagulans, sub-terminal in B. subtilis).

These two probiotics work in a complementary way to support intestinal balance and can be happily combined to enhance microbiotic diversity. When administered together in rat studies, a rise in beneficial lactic bacteria and a reduction in harmful (coliform) bacteria were observed (11).

Bacillus coagulans spores: reported risks?

To date,no adverse side effects have been reported in the scientific literature following supplementation with B. coagulans. Studies confirm it is very well-tolerated and has no mutagenic or genotoxic characteristics (12).

What is irritable bowel syndrome?

Irritable bowel syndrome (IBS) is a benign but debilitating condition of the digestive system thought to affect 10%-15% of the global population. It is characterised by chronic stomach aches and abdominal cramps, impaired intestinal transit and bloating.

A number of theories have been suggested to explain this digestive dysfunction, including problematic intestinal motility and visceral hypersensitivity. However, disruption to microbiota balance, which would make the intestinal barrier more permeable to pro-inflammatory molecules, seems an increasingly plausible explanation (13).

How should Bacillus Coagulans Probiotic be taken?

We recommend taking 2 capsules a day (equivalent to 4 billion microorganisms) with a large glass of water. In general, it is best to take probiotics in the 30 minutes preceding a meal or with a light meal or snack.

Important: we strongly recommend keeping this probiotic refrigerated.

To optimise the effects of this supplement on your gut health, it’s also worth considering:

  1. increasing your intake of soluble fibre (oats, barley, rye...) ;
  2. staying well-hydrated
  3. reducing your consumption of alcohol, spices and fermentable foods (FODMAPs) ;
  4. chewing your food for longer;
  5. reducing your stress levels.

Which other supplements can be combined with B. coagulans ?

When supplementing with probiotics, taking prebiotic fibre helps ‘friendly’ strains become established in the intestinal tract and maximises their chances of survival. So consider combining Bacillus coagulans with inulin or Fructo-Oligosaccharides, extracted from sugar beet using a bioconversion process. (14).

If you experience heaviness after a meal, combine B. coagulans with Digestive Enzymes, a unique complex containing 15 key digestive enzymes (lactase, proteases, amylase...) as well as specific plants associated with maintaining good digestive health (peppermint, fenugreek, ginger, aniseed...) (15-16)

Composition
Daily dose: 2 capsules
Number of doses per pack: 30
Amount per dose
Bacillus coagulans (Weizmannia coagulans) 266.6 mg (4*109 microorganisms)
Other ingredients: acacia gum, white rice flour.
Directions for use
Adults. Take 1 capsule twice a day. Each capsule contains 133.3mg of Bacillus coagulans (2 billion Weizmannia coagulansmicroorganisms).

Attention: best stored in a cool place.
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BOURDIN
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References
  1. A AJ, Suresh A. Oral microbial shift induced by probiotic Bacillus coagualans along with its clinical perspectives. J Oral Biol Craniofac Res. 2023 May-Jun;13(3):398-402. doi: 10.1016/j.jobcr.2023.03.013. Epub 2023 Apr 17. PMID: 37124834; PMCID: PMC10131115.
  2. A AJ, Suresh A. Oral microbial shift induced by probiotic Bacillus coagualans along with its clinical perspectives. J Oral Biol Craniofac Res. 2023 May-Jun;13(3):398-402. doi: 10.1016/j.jobcr.2023.03.013. Epub 2023 Apr 17. PMID: 37124834; PMCID: PMC10131115.
  3. B. coagulans et intestin irritable : Gupta AK, Maity C. Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant]. Medicine (Baltimore). 2021 Jan 22;100(3):e23641. doi: 10.1097/MD.0000000000023641. PMID: 33545934; PMCID: PMC7837859.
  4. Maity C, Gupta AK. A prospective, interventional, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Bacillus coagulans LBSC in the treatment of acute diarrhea with abdominal discomfort. Eur J Clin Pharmacol. 2019 Jan;75(1):21-31. doi: 10.1007/s00228-018-2562-x. Epub 2018 Sep 28. PMID: 30264164.
  5. Madempudi RS, Neelamraju J, Ahire JJ, Gupta SK, Shukla VK. Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020 Jun;12(2):335-342. doi: 10.1007/s12602-019-09542-9. PMID: 30911991.
  6. Ratna Sudha M, Yelikar KA, Deshpande S. Clinical Study of Bacillus coagulans Unique IS-2 (ATCC PTA-11748) in the Treatment of Patients with Bacterial Vaginosis. Indian J Microbiol. 2012 Sep;52(3):396-9. doi: 10.1007/s12088-011-0233-z. Epub 2011 Sep 23. PMID: 23997330; PMCID: PMC3460128.
  7. Abhari K, Shekarforoush SS, Hosseinzadeh S, Nazifi S, Sajedianfard J, Eskandari MH. The effects of orally administered Bacillus coagulans and inulin on prevention and progression of rheumatoid arthritis in rats. Food Nutr Res. 2016 Jul 15;60:30876. doi: 10.3402/fnr.v60.30876. PMID: 27427194; PMCID: PMC4947834.
  8. Baron M. A patented strain of Bacillus coagulans increased immune response to viral challenge. Postgrad Med. 2009 Mar;121(2):114-8. doi: 10.3810/pgm.2009.03.1971. PMID: 19332969.
  9. Abhari K, Shekarforoush SS, Hosseinzadeh S, Nazifi S, Sajedianfard J, Eskandari MH. The effects of orally administered Bacillus coagulans and inulin on prevention and progression of rheumatoid arthritis in rats. Food Nutr Res. 2016 Jul 15;60:30876. doi: 10.3402/fnr.v60.30876. PMID: 27427194; PMCID: PMC4947834.
  10. A AJ, Suresh A. Oral microbial shift induced by probiotic Bacillus coagualans along with its clinical perspectives. J Oral Biol Craniofac Res. 2023 May-Jun;13(3):398-402. doi: 10.1016/j.jobcr.2023.03.013. Epub 2023 Apr 17. PMID: 37124834; PMCID: PMC10131115.
  11. Mazkour S, Shekarforoush SS, Basiri S. The effects of supplementation of Bacillus subtilis and Bacillus coagulans spores on the intestinal microflora and growth performance in rat. Iran J Microbiol. 2019 Jun;11(3):260-266. PMID: 31523411; PMCID: PMC6711872.
  12. Mu Y, Cong Y. Bacillus coagulans and its applications in medicine. Benef Microbes. 2019 Jul 10;10(6):679-688. doi: 10.3920/BM2019.0016. Epub 2019 Jun 17. PMID: 31203635.
  13. Shaikh SD, Sun N, Canakis A, Park WY, Weber HC. Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review. J Clin Med. 2023 Mar 28;12(7):2558. doi: 10.3390/jcm12072558. PMID: 37048642; PMCID: PMC10095554.
  14. Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, Berenjian A, Ghasemi Y. Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications. Foods. 2019 Mar 9;8(3):92. doi: 10.3390/foods8030092. PMID: 30857316; PMCID: PMC6463098.
  15. Malik TF, Panuganti KK. Lactose Intolerance. [Updated 2023 Apr 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532285/
  16. Modi M, Modi K. Ginger Root. [Updated 2022 Nov 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK565886/

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