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Black pepper supplement for digestion & absorption

6 reviewsRead reviews

Extract of black pepper (Piper nigrum) to maximise absorption of nutrients from food
  • Increases bioavailability of a number of micronutrients (2000% for curcumin)
  • Increases activity of digestive enzymes
  • Standardised to 95% natural piperine (the maximum available)
  • Increases thermogenesis
  • Stimulates the taste buds

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90 Veg. Caps

22.00 €


90 Veg. Caps

22.00 €

20.24 €

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No controversial excipients
No sweeteners

Bioperine® is a black pepper extract (Piper nigrum) in vegetarian capsules, standardised to 95% piperine, to support digestive health.

What is piperine?

We’re all familiar with the hotness of black pepper: it is due to the biological activity of several active compounds, in particular piperine. Piperine is an alkaloid used for more than 20 years to maximise the bioavailability of nutrients.

Black pepper is one of three essential natural ingredients used in the majority of Ayurvedic formulations. It can increase absorption of selenium and vitamin C by up to 42% and 50% respectively. Below are just some of the many micronutrients where absorption can be improved by piperine:

  • Curcumin (1);
  • Iron (2);
  • Resveratrol (3);
  • Selenium;
  • Vitamin B6;
  • β-Carotene;
  • Extract of Boswellia serrata;
  • Extract of Ginkgo biloba, and
  • Proteins in general.

What are Bioperine® mechanisms of action?

Bioperine® effects are due to three distinct mechanisms of action:

  • Piperine helps increase intestinal activity of glycoprotein-P which is involved in the transport of many substances (including certain drugs) (4).
  • Piperine modifies the rate of glucurono-conjugation by reducing glucoronic acid content and inhibiting transferase activity (5). This mechanism enables foreign molecules to be solubilised for more effective elimination via urine.
  • Piperine also increases thermogenesis via the release of thermogenic hormones called catecholamines. This results in improved absorption of nutrients in the gut.

What are the benefits associated with Bioperine®?

In addition to optimising bioavailability, piperine also offers digestive benefits: it stimulates appetite and facilitates digestion (by increasing the activity of salivary amylase and trypsin, an enzyme in pancreatic juice which helps ‘break’ proteins (7)).


Piperine also helps increase the bioavailability of certain drugs such as ibuprofen (8). It therefore should not be taken at the same time as medication.

How is Bioperine® produced?

Black pepper is a climbing vine that grows in forest habitats and equatorial climates: it can only be cultivated between the latitudes 15 degrees north and 15 degrees south.

Black pepper is picked when the berries (or drupes) start to turn red: it is at this stage that the amount of essential oil is at its peak. They are then deseeded, dried in the sun till the berries go black, then plunged into boiling water for several minutes. The heat ruptures the peppers’ cell walls and releases heat-resistant enzymes. The drupes are then dried in the open air before the outer coating is removed.

In the case of Bioperine®, the piperine content is then increased so that it makes up around 95% of the natural black pepper extract.

It’s worth noting that while piperine can be synthesised in the laboratory using an enzyme called piperotransferase, Bioperine® contains natural piperine extracts from black pepper drupes, unlike many piperine supplements on the market.

Buy Bioperine® capsules to aid digestion.

What is in Bioperine®

Black pepper extract

Any questions?

Can Bioperine® be combined with other supplements?

Piperine potentiates the bioavailability of many supplements, but it is curcumin supplements known for their powerful anti-inflammatory effects, that most benefit from being combined with Bioperine®. Supersmart has curcumin supplements available to buy such as Curcumin Solution, Natural Curcuma and Super Curcuma.

Curcumin’s bioavailability is actually very low because it is quickly metabolised in the liver. Thus taking 2g of curcumin will only produce a very slight increase in plasma concentrations. However, taking piperine at the same time produces a clear increase in curcumin levels, in the region of 2000%, within around 30 minutes of ingestion (6).

The mechanism responsible is inhibition of glucurono-conjugation: this slows down the breakdown of curcumin by the liver, considerably expanding its window of absorption.


This product is rated 4.5 out of 5 stars
There are 6 reviews






Excellent 6 Reviews
Bence Yves

october 23 2020


Marie Pierre

june 10 2024

Très bon produit que je prends depuis plusieurs années pour renforcer l’effet des autres compléments.

Very good product that I have been taking for several years to enhance the effect of other supplements.

see the translation Translated by SuperSmart - see the original


january 27 2021

T. Bien - bon produit - utilisé avec chrysine

Very good - good product - used with chrysin

see the translation Translated by SuperSmart - see the original


june 26 2020

Sur le long terme, le produit perd un peu de son efficacité. Peut-être faut-il faire un break et cesser de le prendre pendant une semaine pour retrouver un efficacité 100 %. Dans l'ensemble, très bon produit avec un excellent rapport qualité prix.

In the long term, the product loses a bit of its effectiveness. Perhaps it's necessary to take a break and stop using it for a week to regain 100% effectiveness. Overall, a very good product with an excellent quality-price ratio.

see the translation Translated by SuperSmart - see the original

Ezio Cervelli

september 8 2019

molto buono

very good

see the translation Translated by SuperSmart - see the original

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