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Maitake D-Fraction dietary supplement
Maitake D-Fraction dietary supplement
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Maitake D-Fraction®
Immunity
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59.00 €(63.92 US$)
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Description
A premium extract of maitake, the Japanese ‘king of the mushrooms’, widely studied in immunology
  • Maitake (Grifola frondosa) is a famous traditional revitaliser and regenerator from the Japanese pharmacopoeia.
  • Extract standardised to 30% proteoglycans (or ‘D-Fraction‘), maitake’s most powerful compounds.
  • D-Fraction is attracting huge interest among immunology researchers.
  • Extract obtained from the fruiting body of the mushroom, the only significant source of D-Fraction.
  • Greater bioavailability than ordinary beta-glucans.
  • The proteoglycans also have a higher degree of ramification, and are therefore more active.
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Maitake mushroom

Maitake D-Fraction® – Benefits of the ‘king of the mushrooms’ – Review

Maitake D-Fraction® is a dietary supplement containing maitake, a famous mushroom described as a tonic and regenerator in traditional Japanese and Chinese medicine.

This premium maitake extract is standardised to 30% proteoglycans, the mushroom’s most powerful active ingredients (known as ‘D-Fraction’). D-Fraction is the subject of numerous immunology studies.

The supplement Maitake D-Fraction® is part of our Immunity category.

Maitake, the invaluable ‘dancing mushroom’

Maitake (Grifola frondosa), also known as tufted polypore or king of the mushrooms, is a grey-brown fungus native to northern Japan, recognisable by its coral-like structure. Weighing up to around 10 kilos, it is structured around a ramified trunk supporting a large cluster of caps.

This unusual fruiting pattern, reminiscent of a flutter of butterflies, is thought to be the origin of its poetic sobriquet, ‘dancing mushroom’, though this may equally refer to the people who chanced upon it apparently dancing with joy at their discovery. Very rare and highly-prized, this mycological specimen used to be exchanged by Japanese herbalists for its equivalent weight in silver.

Most commonly found in autumn around the base of dead tree stumps (oaks, elms, chestnuts...), maitake grows wild on the east coast of North America as well as in Europe. As a result of its enthusiastic reception by both the culinary world for its rich flavour, and the medicinal one for its remarkable biological activity, it has been cultivated since the 1980s (1).

What are the health benefits offered by maitake?

Practitioners of Japanese and Chinese medicine typically attribute maitake with regenerating and revitalising capacities believed to ‘cleanse heat’ and ‘eliminate damp’ which slows down the flow of energy (Qi) in meridians (2).

We now know that maitake has a high content of beta-glucans. The extraordinary bioactivity of these types of fibre was only understood in the 1980s following the isolation of proteoglycans (beta-glucans bound to proteins): D-Fraction (or Fraction-D) (3). This fraction contains the majority of maitake’s health benefits (4).

More recently, human studies have examined the effects of maitake’s D-Fraction on immunity, particularly on activation of macrophages, T cells and natural killer (NK) cells (5).

The D-Fraction proteoglycans have a higher degree of ramification than ordinary beta-glucans, which appears to be a key factor in their potential high immune activity. They also have greater bioavailability when taken orally than other beta-glucans, and thus superior effects.

It’s also worth highlighting that animal trials are investigating maitake’s potential as a beneficial functional ingredient in managing certain metabolic disorders, especially glucose intolerance (6).

What’s more, maitake has an excellent nutritional composition. It contains a number of B group vitamins, vitamin D, various minerals (potassium, magnesium, calcium, iron, phosphorus...), fibre and amino acids (7-8).

From which part of the mushroom does this maitake supplement come?

Our maitake extract is taken exclusively from the mushroom’s fruiting body, a reliable source of D-Fraction.

It does not contain any mycelium, as this has not been scientifically shown to contain D-Fraction.

How should the supplement Maitake D-Fraction® be taken?

Maitake PD-Fraction® offers a high dose of 100mg of maitake extract per capsule, the extract being standardised to 30% proteoglycans (D-Fraction).

The recommended dose for this supplement is 1 capsule a day. It is for use by adults only.

How can you support your immune system?

By adopting healthy lifestyle habits, you can help support your immune system and general health:

  • take regular, moderate exercise to improve the circulation of your immune cells;
  • get enough sleep (around 8 hours a night), as a lack of sleep weakens immunity;
  • eat a balanced diet, with plenty of fruit and vegetables – sources of vitamins, minerals and antioxidant phytonutrients;
  • learn to manage your stress levels through meditation or yoga, as stress is bad for your immune defences;
  • and wash your hands regularly to prevent infections.

Supplementing with maitake: are there any side-effects?

Maitake supplements are generally extremely well-tolerated and cause very few side-effects. Allergic reactions or mild intestinal discomfort have been reported in a few rare cases (9).

There are no specific contraindications for maitake. However, women who are pregnant or breastfeeding are advised to consult their doctor before starting supplementation.

Synergistic supplements to combine with Maitake D-Fraction®

To support maitake’s ‘defensive’ dimension, it can be combined with cat’s claw or Uncaria tomentosa, a medicinal plant from the Amazon which supports the immune system (10).

To maintain vitality more generally, you can also take Adaptogenic Potion, which, in a single, synergistic formulation, combines the benefits of mycotherapy (reishi, cordyceps, chaga, shiitake and Trametes versicolor) with adaptogen plants from Ayurvedic medicine, such as holy basil (11).

Composition
Daily dose: 1 capsule
Number of doses per pack: 30
Amount per dose
Maitake PD-Fraction®
Extract of maitake standardised to 30% proteoglycans
100 mg
Other ingredients : acacia gum, white rice flour.
Maitake PD-Fraction®, Mushroom Wisdom, USA.
Directions for use
adults. Take one capsule a day.
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References
  1. Mayell M. Maitake extracts and their therapeutic potential. Altern Med Rev. 2001 Feb;6(1):48-60. PMID: 11207456.
  2. Chugh RM, Mittal P, Mp N, Arora T, Bhattacharya T, Chopra H, Cavalu S, Gautam RK. Fungal Mushrooms: A Natural Compound With Therapeutic Applications. Front Pharmacol. 2022 Jul 13;13:925387. doi: 10.3389/fphar.2022.925387. PMID: 35910346; PMCID: PMC9328747.
  3. Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb;2(2):14. doi: 10.3978/j.issn.2305-5839.2014.01.05. PMID: 25332990; PMCID: PMC4202470.
  4. Alonso EN, Ferronato MJ, Fermento ME, Gandini NA, Romero AL, Guevara JA, Facchinetti MM, Curino AC. Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells. Oncotarget. 2018 May 4;9(34):23396-23412. doi: 10.18632/oncotarget.25174. PMID: 29805742; PMCID: PMC5955106.
  5. Kodama N, Komuta K, Nanba H. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. J Med Food. 2003 Winter;6(4):371-7. doi: 10.1089/109662003772519949. PMID: 14977447.
  6. Aoki H, Hanayama M, Mori K, Sato R. Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice. Biosci Biotechnol Biochem. 2018 Sep;82(9):1550-1559. doi: 10.1080/09168451.2018.1480348. Epub 2018 Jun 6. PMID: 29873587.
  7. Patel DK, Seo YR, Dutta SD, Lee OH, Lim KT. Influence of Maitake (Grifola frondosa) Particle Sizes on Human Mesenchymal Stem Cells and In Vivo Evaluation of Their Therapeutic Potential. Biomed Res Int. 2020 Mar 6;2020:8193971. doi: 10.1155/2020/8193971. PMID: 32258147; PMCID: PMC7091544.
  8. Deng G, Lin H, Seidman A, Fornier M, D'Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol. 2009 Sep;135(9):1215-21. doi: 10.1007/s00432-009-0562-z. Epub 2009 Mar 1. PMID: 19253021; PMCID: PMC3751581.
  9. Deng G, Lin H, Seidman A, Fornier M, D'Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol. 2009 Sep;135(9):1215-21. doi: 10.1007/s00432-009-0562-z. Epub 2009 Mar 1. PMID: 19253021; PMCID: PMC3751581.
  10. Yepes-Perez AF, Herrera-Calderón O, Oliveros CA, Flórez-Álvarez L, Zapata-Cardona MI, Yepes L, Aguilar-Jimenez W, Rugeles MT, Zapata W. The Hydroalcoholic Extract of Uncaria tomentosa (Cat's Claw) Inhibits the Infection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) In Vitro. Evid Based Complement Alternat Med. 2021 Feb 24;2021:6679761. doi: 10.1155/2021/6679761. PMID: 33680061; PMCID: PMC7929665.
  11. Jamshidi N, Cohen MM. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Alternat Med. 2017;2017:9217567. doi: 10.1155/2017/9217567. Epub 2017 Mar 16. PMID: 28400848; PMCID: PMC5376420.

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