- Promotes good cellular health by fighting oxidative stress.
- Protects and repairs damaged DNA, providing anti-ageing effects.
- Combines a number of antioxidants that help to repair DNA damage and preserve cellular DNA.
DNA Repair is a completely new formula delivered in vegetarian capsules, that both protects - and increases - our ability to repair DNA, the carrier of genetic information.
Achieving or maintaining optimal health depends first and foremost on good cellular health. The main focus of current scientific research into extending life expectancy is almost certainly the protection and repair of damaged DNA.
Our cells multiply every day but the fragile DNA within each cell is vulnerable to damage by a range of factors including free radical attack and lack of vitamins, minerals and enzymes. When DNA is damaged, cell function becomes impaired, potentially to the point where cells are unable to self-replicate and divide. In fact, DNA suffers damaging events on a daily basis, but when entire generations of cells are affected, it compromises the vital reserves of tissues and organs, dramatically accelerating the ageing process.
Current scientific thinking supports the theory that it is the gradual destruction of DNA which leads first to accelerated ageing and then to overall impairment of the body, with a decline in capacity for self-repair that becomes increasingly ineffective with age. Self-replication of cells thus takes place in a damaged or corrupted form and cell division subsequently ceases to occur.
This degenerative process can, however, be impeded with selective use of nutritional supplements. DNA Repair contains specific plant extracts, vitamins, minerals and antioxidants that act synergistically to support DNA repair processes.
AC-11® is a patented, water-soluble plant extract of Uncaria tomentosa. A number of clinical studies have confirmed the potency of its carboxyl alkyl esters (CAE) in repairing cell DNA damage, whether caused by UV exposure or any other source of oxidative stress. What's more, the benefits of taking AC-11 extend well beyond those related to repair of damaged DNA.
AC-11 standardised in CAE, is thus without doubt one of the most active anti-ageing agents, complemented by other antioxidant and reparative substances.
The broccoli extract in DNA Repair is standardised to 10% sulforaphane. This widely studied glucosinolate is an enzyme activator. Comparable to I3C (indole-3-carbinol), it is able to neutralise carcinogens by activating so-called phase 2 liver detoxification enzymes. It can also protect against certain chemically induced cancers such as colon and prostate cancer. It is a major protector of cell integrity.
Boosting its action, is an extract of wasabi or horseradish, added for its content in various glucosinolates which play a role in regulating liver enzymes, preserving DNA and improving the inflammatory response.
Arabinogalactans extracted from larch (Larix occidentalis) impede inflammatory processes and are highly effective at supporting the immune system by increasing NK cells (hence their use in liver metastases) and lymphokines, thus combatting the destruction of cell DNA by various aggressors.
Curcuma longa, and particularly the curcuminoids it contains, are among the most effective substances for preserving cellular DNA and act as powerful detoxification agents. All the research on curcuma confirms it has general antioxidant properties, protects against cancer and reduces inflammatory processes, and that supplementing with it reduces mutagenic elements.
SOD-Gliadins Complex is the only stable, oral form of SOD (superoxide dismutase). This melon extract combined with a wheat protein (gliadin) protects DNA from oxidative damage.
AuroraBlue is an exclusive powder complex of Vaccinium berry species (alaskaense, ovaliforium, membranaceum, uliginosum, cespitosum) which is rich in anthocyanins, proanthocyanidins, flavonols (quercetin, myricetin, fisetin, catechins), stilbenes, vitamins (C and K), minerals and oligo-elements. The excellent nutritional profile of this unique complex and the substances it provides, enable healthy cell replication to take place and combats inflammatory and oxidative processes, thus protecting DNA from attack at a cellular level.
Chlorophyll, in the form of sodium copper salt, complements these other substances by combatting free radicals and by binding to certain toxic chemicals, thus aiding their elimination from the body.
Last but not least, this product also contains vitamin B9 in its most bioavailable form (Quatrefolic), vitamin B12 (methylcobalamine) and zinc pidolate - three essential catalysts that participate in redox and methylation of DNA.
This complex can be taken for long periods, either on its own or combined with other supplements available to buy at Supersmart such as cycloastragenol which also stimulates DNA repair by activating telomerase, or even with pyrroloquinoline quinone (PQQ) which protects mitochondrial DNA.
Buy DNA Repair capsules to support DNA repair processes.
Daily dose: 2 capsules Number of doses per pack: 30 |
Amount per dose |
AC-11® (proprietary extract of Uncaria tomentosa standardised to 8% carboxy alkyl esters) | 350 mg |
Extract of broccoli standardised to 10 % sulforaphane glucosinolate | 150 mg |
Extract of larch standardised to 85 % arabinogalactans | 125 mg |
Extract of Curcuma longa standardised to 95 % curcuminoids | 100 mg |
SOD-gliadins complex combining extract of melon (Cucumis melo L) with extract of wheat (Triticum vulgare) on a plant maltodextrin base providing 500 IU (NBT units) of SOD | 100 mg |
Sodium copper salt of chlorophyll (including 4mg of copper, ie, 400% AJR) | 100 mg |
AuroraBlue® (Proprietary powder blend of Vaccinium alaskaense, Vaccinium ovaliforium, Vaccinium membranaceum, Vaccinium uliginosum, Vaccinium cespitosum) | 100 mg |
Extract of wasabi 4:1 | 50 mg |
Zinc pidolate (including 3 mg zinc, ie 20 % AJR) | 15 mg |
Methylcobalamine | 200 mcg |
Quatrefolic® acid (6S)-5-methyltetrahydrofolic acid (from 200 mcg of 54-59% glucosamine salts and (6S)-5-methyltetrahydrofolic acid) | 108 mc |
Other ingredients : Acacia gum, rice flour.
Quatrefolic®, Gnosis, Italy. AuroraBlue®, Denali, USA. AC-11® is a trade mark of Optigenex Inc., USA. (Patente europeia N.º 1,485,114 A2, 1,096,943 B1) |
Senolytic Complex is a completely new ‘senolytic’ formulation for fighting the ageing process, based on the very latest discoveries in anti-ageing medicine, now available to buy at Supersmart. The term ‘senolytic’, recently coined by the scientific community, describes the ability to eliminate senescent cells (ie, aged cells), the presence of which has been identified in recent years as being, along with oxidative stress and telomere shortening, one of the causes of ageing. Since there was previously no way of preventing or slowing down this process, Senolytic Complex constitutes a truly revolutionary treatment.
The formulation contains the most powerful, natural, senolytic compounds identified to date: quercetin (in a form 20 times more bioavailable than standard quercetin), theaflavin, and most importantly, fisetin, an extraordinary flavonoid that’s really setting the scientific community alight.
Senolytic Complex is for anyone over 40, whether as a course of treatment, or as long-term supplementation, to eliminate senescent cells and prevent their reappearance.
It is particularly recommended for the following groups of people:
In 2014, researchers achieved a major advance in the fight against ageing. They identified old, worn-out cells in the tissues of subjects aged over 40. Termed ‘senescent’, these zombie-like cells (1) are deformed and unable to divide, and are distributed throughout the body’s tissues. Though no longer functioning normally, they are not eliminated and thus accumulate pathologically.
These cells are rare in young people but increase with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, kidneys and skin (2-3).
Unfortunately, senescent cells do not just take over, they also impede the activity of neighbouring healthy cells by continually releasing pro-inflammatory cytokines (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) into the extracellular environment (4-7). These substances are really distress calls: they signal to other cells the advanced state of deterioration in which they find themselves, but at the same time, they significantly affect the function of neighbouring healthy cells (8)!
Over the last three years, a number of studies have shown that the level of senescent cells in the body is directly linked to the pace of ageing (9) and the development of age-related health problems. Even a small amount of these cells is enough to wreak havoc in tissues(10) and induce the onset of many age-related problems: systemic inflammation, arthritis, atherosclerosis, chronic diseases (11), sarcopenia, cataracts, insulin resistance, vascular hypo-reactivity (12) (13) ...
These cells normally destroy themselves in a process called apoptosis, in order to avoid damaging the body. However, this mechanism does not always work in which case the senescent cells continue to parasitize the body and cause chaos all around them (14).
Fortunately, researchers have identified several compounds that are specifically capable of repairing this defective mechanism and bringing about the self-destruction of these senescent cells. These extraordinary compounds are called ‘senolytics’.
The first study to identify senolytics was published in 2015 in the well-known scientific journal Aging Cell (15). Quercetin, a natural flavonol compound, combined with an anti-cancer drug, was found to dramatically decrease both the number of senescent cells and secretion of pro-inflammatory factors in the organism studied. In just five weeks, this combination resulted in a significant reduction in mortality and physical deterioration.
Dozens of studies have since identified natural compounds with the same properties (16-17). This has led to the development of a revolutionary new therapy, senolytic treatment, which is able to selectively destroy senescent cells and thus reduce the severity of age-related diseases, increase resilience and longevity, and delay the effects of ageing.
The treatment is essentially a massive ‘spring clean’, after which healthy cells regain control of the body and again function at full capacity. It represents a significant advance in the fight against ageing.
The very latest research shows that a formulation such as this can produce powerful rejuvenating effects, improve the condition of those affected by age-related health problems, slow down the ageing process and extend lifespan. Exceptional benefits which place this dietary supplement right at the top of anti-ageing nutrition and which should come as welcome news for many people…
Daily dose: 3 capsules Number of doses per pack: 30 |
Amount per dose |
Quercefit® (Complex of phytosomes of sunflower and Sophora japonica quercetin standardised to 40% lecithin and 40% quercetin) | 400 mg |
Bromelain 2000 GDU/g | 200 mg |
Vitamin C (Ester C®) | 100 mg* |
Fisetin from Rhus succedanea stem | 100 mg |
Extract of decaffeinated black tea leaves | 300 mg |
Nicotinamide mononucleotide | 10 mg |
Other ingredients: acacia gum, white rice flour.
*125% of RDA for Vitamin C Quercefit®, Indena, Italy. Ester C®, Ester C Company. |
Attention: fisetin should not be taken in conjunction with antivitamin K drugs, which are commonly used oral anticoagulants (30).
Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.
A number of proteins and amino acids are being studied for their potential effects on human longevity. Here we take a look at 3 key anti-ageing proteins and the various ways they can be used to help ‘hold back time’.
Mitochondria (the cells’ power plants) deteriorate with age but you can help take care of yours and slow down the ageing process with our tips and natural remedies.
Does a dietary supplement past its expiry date necessarily have to be thrown away? Read on for the answers.