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Benefits of neurobiotics: probiotics specifically studied for cognition and brain health
A dual neurobiotic approach
NeuroBiotics Formula is a neurobiotic dietary supplement combining:
- the patented probiotic strain Bifidobacterium breve MCC1274;
- and the proprietary SuperSmart NeuroBiotics Proprietary Blend™, containing four specific probiotic strains of the species Lactobacillus plantarum, Lactococcus lactis, Bifidobacterium bifidum and Bifidobacterium infantis.
This association focuses on the gut-brain axis, which links the gut microbiota to the central nervous system and plays a role in various mechanisms associated with cognitive functions.
Cognitive performance and brain health
Bifidobacterium breve MCC1274 has been the subject of more than 20 scientific studies, including two randomised, double-blind, placebo-controlled clinical trials conducted in adults with mild cognitive impairment:
- the first, involving 80 participants over 16 weeks, suggests an improvement in cognitive function scores (immediate memory, delayed memory, visuospatial abilities) compared with the placebo group (1);
- The second, involving 130 participants aged between 65 and 88 over a period of 24 weeks, reported an increase in orientation scores as well as a slowing of the progression of brain atrophy measured by MRI, compared with the placebo group (2).
Neurotransmitters and the gut-brain axis
The Lactobacillus plantarum and Lactococcus lactis strains present in our proprietary blend possess genes that enable them to synthesise:
- GABA, the main inhibitory neurotransmitter in the nervous system;
- and tryptophan, a precursor of serotonin, an essential neurotransmitter.
These compounds play a key role in the transmission of nerve signals and the regulation of neuronal activity (3–4).
Oxidative stress and neuroprotection
Further preclinical data suggest that certain strains in SuperSmart NeuroBiotics Proprietary Blend™ may produce antioxidant enzymes:
- Lactobacillus plantarum may produce catalase, an enzyme involved in the breakdown of hydrogen peroxide;
- Bifidobacterium infantis may produce SOD, an enzyme that helps to neutralise superoxide radicals.
These enzymes play a role in cellular defences against oxidative stress, a mechanism that has been extensively studied in relation to brain ageing and neuroprotection (5–6).
Inflammation, biological barriers and brain health
Bifidobacterium infantis and Bifidobacterium bifidum have been studied, in preclinical settings, for their potential ability to modulate inflammation and preserve the integrity of the intestinal barrier, a structure that controls the passage of substances from the intestine into the bloodstream (7).
More broadly, short-chain fatty acids (SCFAs) produced by certain gut bacteria are being researched for their role in maintaining the intestinal barrier and the blood-brain barrier, which regulates the exchange between the bloodstream and the brain (8).
4 key benefits and reasons to buy our neurobiotic dietary supplement
Our NeuroBiotics Formula dietary supplement stands out for 4 key benefits:
- a patented and clinically studied neurobiotic strain: Bifidobacterium breve MCC1274 has been the subject of more than 20 scientific studies, including two randomised, double-blind, placebo-controlled clinical trials on cognitive health;
- a dual approach: a targeted strain combined with a complementary proprietary blend: the patented MCC1274 strain is combined with our own proprietary blend, SuperSmart NeuroBiotics Proprietary Blend™, containing four strains selected for their synergistic functions within the gut-brain axis (production of neuroactive compounds, combating oxidative stress and preserving the intestinal barrier);
- enteric-coated capsules: our capsules protect the bacteria throughout the digestive tract, where gastric acidity can usually destroy some of them, ensuring their survival until they reach the intestine, where they can colonise the microbiota;
- a simple, carefully formulated composition: apart from its active probiotics, our product contains only two other ingredients: a hypromellose capsule (a derivative of cellulose, a natural fibre) and acacia gum. It contains no unnecessary excipients or additives.
What is the composition of this neurobiotic complex?
| Daily dose: 2 capsules Number of doses per pack: 30 |
Daily dose |
| Bifidobacterium breve MCC1274 | 12 x 10⁹ CFU |
| SuperSmart NeuroBiotics Proprietary Blend™: | |
| Lactobacillus plantarum CNCM I-4909 | 5.5 × 10⁹ CFU |
| Lactococcus lactis CNCM I-5352 | 5.5 × 10⁹ CFU |
| Bifidobacterium bifidum CNCM I-5091 | 0.5 × 10⁹ CFU |
| Bifidobacterium infantis CNCM I-5090 | 0.5 × 10⁹ CFU |
|
Other ingredients: acacia gum, hypromellose capsule. Strain MCC1274 is an active probiotic strain developed by Morinaga Milk Industry. |
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What is a neurobiotic and how is it related to psychobiotics?
Neurobiotic: an approach focused on brain health
The term ‘neurobiotic’ is used to refer to probiotics studied for their interactions with the brain, particularly in the context of cognitive function, brain ageing and neuroprotection.
Their significance lies in particular in the gut-brain axis, a two-way communication system linking the gut microbiota to the nervous system.
What is the difference between the terms ‘neurobiotic’ and ‘psychobiotic’?
The term ‘psychobiotic’, introduced into the scientific literature in 2013 (9), refers to probiotics studied for their interactions with the nervous system, particularly in the context of mood, stress and cognitive functions.
This communication involves, in particular, the vagus nerve, the immune system and various metabolites and neurotransmitters produced or modulated by the microbiota.
In the context of NeuroBiotics Formula, the term ‘neurobiotic’ places greater emphasis on brain health, cognitive functions and neuroprotection.
Who is it for?
NeuroBiotics Formula is particularly suitable for:
- adults aged 50 and over: as we age, the gut microbiota tends to change and lose diversity, whilst low-grade inflammation and oxidative stress are among the mechanisms studied in relation to brain ageing;
- people interested in the gut-brain approach: the gut-brain axis is currently the subject of extensive research into the interactions between the gut microbiota and brain health;
- People who are cognitively active: certain students, professionals or older adults may place particular demands on their cognitive abilities and be mindful of maintaining them in the long term.
What is the link between an imbalance in the gut microbiota and brain health?
The composition of the gut microbiota can be affected by numerous factors:
- diet;
- chronic stress;
- antibiotic use;
- or even aging.
When this balance is disrupted (a condition known as dysbiosis), the tight junctions that ensure the intestinal wall remains impermeable may become compromised; this is currently being studied as a factor that may contribute to low-grade systemic inflammation.
The gut microbiota also plays a role in modulating certain neuroactive pathways.
This is particularly the case for pathways involving serotonin – over 90% of which is synthesised in the digestive tract – and GABA, two neurotransmitters studied in the context of the gut-brain axis (10).
What is the recommended dose of NeuroBiotics Formula?
Each daily dose of NeuroBiotics Formula (2 capsules) provides 24 billion CFU, comprising 12 billion CFU of Bifidobacterium breve MCC1274 and 12 billion CFU of the SuperSmart NeuroBiotics Proprietary Blend™ (Lactobacillus plantarum CNCM I-4909, Lactococcus lactis CNCM I-5352, Bifidobacterium bifidum CNCM I-5091 and Bifidobacterium infantis CNCM I-5090).
It is recommended to take the 2 capsules approximately 30 minutes before a meal, in order to optimise their passage through the digestive tract.
One box provides a 30-day supply.
Which synergistic dietary supplements should be taken with NeuroBiotics Formula?
Complementary nutrients for brain health
Certain nutrients are traditionally associated with brain health.
This is the case with Ginkgo biloba, which is rich in flavonoids and terpenes (ginkgolides and bilobalides) and is commonly used to support cerebral microcirculation.
Another example is huperzine A, an alkaloid extracted from the Huperzia serrata plant, which has been studied for its potential role in maintaining levels of acetylcholine, a key neurotransmitter for cognitive function.
You’ll find these nutrients, combined with other targeted compounds, in our Neurex™ formula.
Acetyl-L-carnitine arginate
Acetyl-L-carnitine arginate, meanwhile, is a molecular combination of carnitine and arginine.
Both of these compounds are involved in cellular energy metabolism, including at the neuronal level, where energy requirements are particularly high.
You can buy acetyl-L-carnitine arginate as a dietary supplement, such as Acetyl L-Carnitine Arginate.
CDP-Choline
CDP-choline is a precursor of phosphatidylcholine, a phospholipid that forms part of neuronal cell membranes.
It is also involved in the biosynthesis of acetylcholine.
To complement your neurobiotic formula, buy CDP-choline from CDP Choline.
Quality, purity and traceability
Our NeuroBiotics Formula combines the patented Bifidobacterium breve MCC1274 strain, developed by Morinaga Milk Industry, with a proprietary blend of four probiotic strains, in a formula that meets high quality standards.
Its composition is deliberately simple, containing only the active probiotic strains, gastro-resistant hypromellose capsules and acacia gum as an excipient, in order to minimise unnecessary ingredients whilst protecting the bacteria until they reach the gut.
Each batch undergoes rigorous quality controls to verify its compliance with established specifications.
Certificates of Analysis (COAs) for marketed batches can be viewed directly on this page, in the interests of transparency and traceability.
What is in NeuroBiotics Formula
Any questions?
Our team of nutrition experts and scientists has the answers.
Probiotics studied in the context of brain health, known as psychobiotics or, more specifically, neurobiotics, are being investigated for their link to several mechanisms:
- the production of neurotransmitters such as GABA, which are involved in nerve communication;
- the modulation of inflammation, which influences brain ageing;
- and the maintenance of the integrity of the gut barrier, which limits the passage of undesirable substances into the bloodstream and thus helps to preserve the balance of the gut-brain axis.
Certain strains, such as Bifidobacterium breve MCC1274, have been the subject of clinical trials investigating their potential role in maintaining brain volume and cognitive function as we age.
No: the effects of probiotics that have been studied depend largely on the strain.
Two bacteria belonging to the same species may therefore have different properties and lack the same level of scientific evidence.
For brain health, it is therefore particularly important to prioritise strains that have been precisely identified and specifically studied in this field.
The effects of probiotics on memory depend in particular on the strain being studied: not all probiotics have the same scientific evidence regarding cognitive function.
Bifidobacterium breve MCC1274 stands out due to clinical trials that have specifically assessed immediate memory, delayed memory and other cognitive abilities in adults with mild cognitive impairment.
Bifidobacterium breve MCC1274 stands out in particular due to two clinical trials that assessed its effects on various cognitive functions as well as on markers linked to brain atrophy.
In NeuroBiotics Formula, this strain is combined with specific strains of Lactobacillus plantarum, Lactococcus lactis, Bifidobacterium bifidum and Bifidobacterium infantis, selected for their complementary mechanisms of action, which have been studied in relation to the gut-brain axis: production of neuroactive compounds, antioxidant defences, modulation of inflammation and maintenance of the intestinal barrier.
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