Research conducted over the last few years into anti-ageing molecules has led to the discovery of fundamental substances capable of increasing life expectancy, in some cases, significantly so.
In a single, synergistic formulation, Longevity Nutrients combines the main substances now recognised as powerful anti-ageing weapons, capable of extending lifespan in perfect health. This complex can be taken on its own or alongside other anti-ageing substances, to complement and boost their effects.
Still known as beta-alanine-L-histidine, this dipeptide is a molecule found in human cells with a long lifespan, such as skeletal muscle cells and brain neurons, but levels tend to fall with age - a decrease of 63% is seen in muscle tissue between the ages of 10 and 70.
L-carnosine is recognised for its antioxidant properties, and its ability to reduce the process of glycation - the ‘caramelisation'of proteins. It protects muscle cell membranes from oxidation and enables cardiac muscle to contract more effectively.
It is one of a small group of ingredients capable of extending the lifespan of human cells in vitro. It has been shown in culture, particularly in lung fibroblasts, to counteract telomere damage and shortening by around 32%. In the presence of L-carnosine, human fibroblasts experience 8 to 10 times more cell divisions before becoming senescent, and thus cell lifespan is significantly longer.
Animal experiments have clearly demonstrated that any substance capable of restricting the effects of insulin helps increase life expectancy. Indeed, this is also the level at which calorie restriction acts. Thus any substance that can reduce insulinaemia and glycaemia restricts the ageing process.
Among the many plants used in Chinese and ayurvedic medicine is Berberis vulgaris, the berries of which contain a powerful plant alkaloid: berberine. This substance appears to be highly effective at increasing the cells sensitivity to insulin as well as at mimicking calorie restriction by stimulating the enzyme AMPK (Adenosine Monophosphate Kinase) which prevents or repairs cell damage. In addition:
Berberine's action in the body is similar to that of the drug Metformin but it has none of the latter's minor risks. Metformin's ability to extend lifespan in mammals has been widely demonstrated.
Plant polyphenols have demonstrated particular promise in resolving problems associated with ageing. Apple polyphenols have been shown to extend lifespan by 12% in three recent studies conducted on yeasts (Cerevisiae), worms (C. elegans) and flies (D. melanogaster). They appear to work by activating genes that stimulate endogenous antioxidant defences and by inhibiting other genes involved in premature death. Epidemiological studies confirm that consumption of flavonoids in general, particularly those from apples, is positively associated with human longevity.
Among the polyphenols found in apple peel is phloridzin, a flavonoid from the chalcone group which reduces resistance to insulin and is effective at combatting glycation via several synergistic mechanisms, including a specific effect on the membrane of the small intestine. This mechanism is also behind the decrease in visceral fat stores.
In addition, apples are rich in chlorogenic acid, catechins, epicatechins and various tannins which are also potent antioxidants (with an ORAC value three times that of green tea extract). Apple polyphenols protect against free radicals, in particular by inducing a 20%+ increase in the activity of paraoxanase, an endogenous antioxidant. In the context of anti-ageing, they are mainly used as preventive, anti-cancer agents as they reduce the risk of colon cancer by almost 50%.
Reishi has been used medicinally for over 2000 years and was justifiably known in ancient times as the ‘mushroom of immortality'. Over recent decades, researchers have been focusing on analysing its various compounds. Science has thus confirmed that reishi has multiple properties which provide the body with all-round protection against a variety of diseases that unquestionably reduce longevity. Among the hundred or so active compounds present in reishi, scientists have identified three specific substances with powerful anti-ageing effects:
What makes this mushroom unique is its ability to act in several places at once, triggering important changes that contribute to increased longevity: it protects cell and mitochondrial DNA from the oxidative damage that contributes to ageing and cancer, it increases expression of a longevity gene and extends life expectancy in a number of species, from yeasts and simple worms to mice and other mammals.
Researchers investigating its effects in laboratory mice clearly demonstrated that reishi consumption was associated with an increase in the animals lifespan of between 9% and 20%, which equates to 16 additional years for humans.
Centrophenoxine was developed in 1959 and has been widely used for more than 30 years to treat brain disorders associated with ageing and changes in memory. It consists of two substances, DMAE (dimethylethanolamine) and PCPA, both of which are potent antioxidants that protect the brain from radical damage. It counteracts age-related decreases in protein DNA, re-enabling information to be stored in the long-term memory and improving alertness, after just a few weeks supplementation.
Centrophenoxine supplementation is thus extremely effective at combatting ageing of the brain, improving cerebral and neuron function and oxygen consumption, and capacity for memorising and concentrating. Above all, centrophenoxine is the only known agent that can reduce accumulation of lipofuscin, an ageing-related toxin, in the cells of the brain, heart, lungs and skin. Cells ‘invaded' by lipofuscin, a kind of metabolic waste product, lose the ability to communicate and function correctly. Long-term administration of centrophenoxine has been shown to significantly increase lifespan in laboratory animals.
Traditionally used to reduce feelings of stress, anxiety and fear, L-theanine - derived from the leaves of green tea (Camellia sinensis) - has also been shown to be a specific anti-ageing amino acid. Taking high doses of L-theanine is known to have an effect on obesity, hypertension, heart rate, blood lipid levels and cancer risk.
German studies by human nutrition researchers, conducted on C. elegans nematodes, are now indicating that this substance can prolong lifespan by between 3.6% and 4.4%. According to the researchers, “Taken together, these findings suggest that this compound may be worth evaluating in mammals and humans with regard to the prevention of ageing”. This formulation, with selected active ingredients, can be taken on its own or alongside other innovative substances such as:
For long-lasting support in the fight against ageing, you can alternate between Longevity Nutrients and other anti-ageing supplements. The formulation AMPK Booster, for example, combines three natural extracts for reactivating AMPK, while the complex Natural Rapalogs contains five natural inhibitors of the mTor signalling pathway. You may also be interested in the innovative anti-ageing molecule Nicotinamide Mononucleotide (NMN).
| Daily dose : 4 capsules Number of doses per pack : 30 |
Amount per dose |
| L-carnosine | 400 mg |
| Berbérine (from 365 mg of Phellodendron amurense extract standardised to 97% berberine) | 350 mg |
| Extract of apple standardised to 80% polyphenols | 300 mg |
| Extract of reishi standardised to 20% polysaccharides | 300 mg |
| Centrophenoxine | 300 mg |
| L-theanine | 300 mg |
| Other ingredients : Microcrystalline cellulose, magnesium stearate, silicon dioxide. | |
Finding a way of stopping the ageing process has been the stuff of dreams for generations. But now it's on the way to becoming reality as Australian and American scientists believe they've found a way of not just pausing the ageing process but rewinding it. Nicotinamide mononucleotide (NMN) is a precursor of NAD+ (nicotinamide adenine nucleotide) and NADH biosynthesis. This new compound should not, however, be confused with nicotinamide riboside (NR) and other substances already on the market even though they may share certain properties, particularly at a genetic level; NMN is significantly more powerful than NR.
NMN not only helps prolong life expectancy but has also shown promise in treating type 2 diabetes. This degenerative disease is directly linked to over-consumption of fat and calories which overwhelm adaptive metabolic pathways. Mouse studies showed that NMN improved glucose tolerance by restoring NAD+ levels. It enhanced insulin sensitivity in the liver, restored impaired gene expression related to oxidative stress, inflammatory response and the circadian rhythm by activating SIRT1.
At a conference on the biology of ageing organised by the Ellison Medical Foundation, Dr Shin-Ichiro Imai demonstrated that sirtuins are necessary for calorie restriction to be able to improve the activity of orexin, a brain hormone which enhances cells' sensitivity to insulin and prevents increases in body fat. However sirtuins alone are not enough - cellular NAD+ must also be present for these beneficial processes to work. The problem is, levels of NAD+ decline both with age and as a result of a high-fat diet. The good news, according to Dr Imai, is that in NMN-treated mice, researchers observed an increase in NAD+ synthesis, suggesting NMN could be a potential treatment for type 2 diabetes.
Found in all living cells, NAD+ is a coenzyme involved in redox reactions. It consists of two nucleotides linked by their phosphate group. One nucleotide contains an adenine, the other a nicotinamide. It helps enzymes transfer electrons during redox reactions to form ATP and is thus an aid to energy supply. However, levels decline with age - the NAD+ in an older person's cells will have fallen by more than 50%. The mitochondria then produce less energy and cells age. Fortunately, this process is not irreversible and intercellular energy mechanisms can be restored if levels of NAD+ are increased. In addition, NAD is an essential cofactor of key longevity enzymes called sirtuins, activating them directly. Sirtuins play a fundamental role in life expectancy as they deactivate particular genes that lead to ageing via inflammatory processes. Thus the combined fall in sirtuins 1 and 3, and in NAD+, can cause cerebral degeneration, vascular inflammation, fatigue, loss of muscle strength, increased fat stores around the liver and abdomen and insulin resistance leading directly to metabolic syndrome. All of these processes can be reversed by means of calorie restriction or supplementation with nicotinamide mononucleotide.
The mitochondria are at the heart of the problem. When they stop communicating properly with the cell nucleus, it is almost as if the cells are deprived of their energy source or battery - their nuclei shrink and ageing becomes inevitable. For Professor David Sinclair, “The ageing process can be compared to a married couple - when they're young, they communicate well, but over time, that communication breaks down. And just as with a married couple, restoring communication solved the problem”. This scientist therefore sees the decline in mitochondrial function and communication as a reversible process. He explains that NAD+ is the central pillar of cell communication but that it decreases sharply with age - until now, the only known way of preventing this loss has been through intensive exercise or calorie restriction.
An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases (cancer and type 2 diabetes). When Professor Sinclair and his colleagues injected this rare substance into two year-old mice, they observed, after just one week's treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals. According to Dr Nigel Turner, a pharmacologist at the University of New South Wales,: “It's like a 60 year-old being similar to a 20 year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".
In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact. The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN's ability to activate all seven of the SIRT genes involved in extending longevity. He believes nicotinamide mononucleotide could be a new class of superdrug capable of both preventing diseases such as cancer (via inhibition of HIF-1, a molecule that impairs intracellular communication and plays a role in cancer development) and Parkinson's disease, and extending life expectancy to 150 years. In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.
In addition to this innovative formulation, you may also be interested in other anti-ageing supplements that offer effective and long-lasting protection from the effects of ageing. The potent AMPK Booster, for example, is formulated to reactivate AMPK, a key enzyme of metabolism, levels of which decline with age. The complex Natural Rapalogs contains five natural inhibitors of mTOR proteins, inhibition of which may combat premature ageing. You can also benefit from the optimised formulation Longevity Nutrients which combines a selection of natural anti-ageing nutrients.
| Daily serving: 1 capsule Number of servings per box: 30 |
Amount per dose |
| Nicotinamide Mononucleotide | 125 mg |
| Other ingredients: Acacia gum | |
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