What do studies show about Nicotinamide Mononucleotide?
An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases.
When Professor Sinclair and his colleagues injected this rare substance into two-year-old mice, they observed, after just one week's treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals.
According to Dr Nigel Turner, a pharmacologist at the University of New South Wales, “It's like a 60-year-old being similar to a 20-year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".
In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact.
The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN's ability to activate all seven of the SIRT genes involved in extending longevity.
In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.
Nicotinamide mononucleotide is a nucleotide composed of ribose and nicotinamide (vitamin B3). It is a precursor of nicotinamide adenine dinucleotide (NAD), a major coenzyme in the body involved in redox reactions.
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