Modern science is gradually rediscovering the extraordinary therapeutic properties of plants, particularly those which at first appear quite unremarkable. Such is the case with the pumpkin and the oil extracted from its seeds.
This oil has been produced in Europe for over 300 years from the genus Cucurbita pepo, the botanical name for a wide range of cultivars including squash and pumpkin. Ranging in colour from dark green to red, the oil is obtained by pressing the pumpkin’s seeds. It is not suitable for cooking as heating it produces a bitter taste and largely destroys its monounsaturated and polyunsaturated fats, the source of its therapeutic benefits.
A review of the scientific data highlights five key properties of pumpkin seed oil.
1. For problems of the prostate
The most widely-researched property of this vegetable oil is undoubtedly its effects on the prostate. This is probably its main benefit and most distinguishing feature. Studies show it may improve benign prostatic hyperplasia (enlarged prostate), prostatitis (inflammation of the prostate), as well as prostate cancer and the problems associated with it: reduced urinary flow, bladder compression, urinary discomfort and infections, inflammation and pain when passing water …
This beneficial property may be due to its high content in phytosterols and zinc (the prostate itself has a high zinc content). A supplement specially formulated to address prostate problems, , can also be taken alongside pumpkin seed oil.
2. For the capillaries and skin
Pumpkin seed oil is also used in men to stem hair loss, particularly androgenetic alopecia (male pattern baldness) which causes varying degrees of hair loss on the crown of the scalp. Regular oral supplementation with 1 gram of pumpkin seed oil, together with topical application, produces good results in terms of hair regrowth. These effects are thought to be linked to its hormonal activity.
Pumpkin seed oil is not only good for the hair but for the skin too, as a result of the antioxidant properties of the oil’s fatty acids. Topical application thus helps reduce skin inflammation and promotes new cell growth. It also contains beneficial levels of , a nutrient widely-known for its anti-wrinkle action and recognised anti-ageing effects.
3. For the circulation
Pumpkin seed oil also has anti-coagulant properties and thus stimulates circulation in the limbs and reduces risk factors for blood clots.
4. For hormones
The naturally high phytoestrogen content of pumpkin seed oil is the reason it is recommended for menopausal women. It helps reduce hot flushes, headaches, joint pain, menstrual cramps and mood changes, and at the same time increases levels of ‘good’ HDL-cholesterol.
5. For the cardiovascular system
Pumpkin seed oil is very high in polyunsaturated fatty acids, the health benefits of which are well-established. These PUFAs include oleic and linoleic acids which help to reduce hypertension and balance cholesterol levels, as well as addressing problems related to atherosclerosis, various heart conditions and even stroke.
Consuming pumpkin seeds themselves boosts these beneficial effects because they contain magnesium which is essential for the formation of ATP, and the synthesis of DNA and RNA.
Are there any contraindications related to pumpkin seed oil?
Yes, but they are minor:
• You should not exceed 1 gram of oral supplementation per 24 hour period.
• Applying undiluted oil to the skin may cause slight irritation.
• If you’re on medication for high blood pressure, consult your doctor before taking this oil.
• It may cause dermatitis or swollen eyelids in highly allergic individuals.
• You should ideally choose gastro-resistant capsules (softgels) as rancidity of the oil may cause stomach problems.
• These minor side-effects are rare and should not deter you from taking this natural, easy-to-take, multi-beneficial supplement.
CompositionPumpkin Seed Oil 500 mg
|Dose journalière : 2 softgels
Number of doses per pack: 30
|Pumpkin seed oil
|Vitamin E (D-alpha tocopherol)
Directions for usePumpkin Seed Oil 500 mg
Adults. Take 2 softgels a day.
Xanthohumol is a hop flower supplement containing an exceptional antioxidant flavonoid called xanthohumol. It’s a phenolic compound that’s 200 times more powerful than the resveratrol in red wine, and offers truly exceptional, cell-boosting properties. Beer is the only dietary source of xanthohumol though the levels it contains are very low.
Xanthohumol, the antioxidant in beer that has superseded resveratrol in red wine
Wine-lovers appreciate the drink’s subtlety and sophistication but they also know it’s an exceptionally rich source of antioxidants. Indeed one such antioxidant is the most widely-studied anti-ageing substance ever: resveratrol. However, new research shows that beer is more than a match for its great rival. Beer is the only dietary source of xanthohumol, a natural cytoprotective antioxidant that’s 200 times more powerful than the resveratrol in red wine!
It was Hildegarde de Bingen, a 12th century Benedictine nun and pharmacologist, who was responsible for introducing hops into beer. Before that, monks had used mainly coriander, gentian or sage to flavour and preserve their precious nectar, which was given to pilgrims in monasteries and abbeys. It was immediately evident that the hop offered many benefits: with its preservative properties and positive effects, it quickly became an essential ingredient in the recipe. Over the centuries that followed, it would go on to be used by generations of brewers, right up to the present day. Though the monks had no way of knowing it, its meteoric rise was due to the hop’s high content in phenolic compounds – particularly xanthohumol. The problem is that these compounds, which come from the hop flower, are very delicate and tend to make the beer a bit cloudy. The majority of modern, large-scale beer producers therefore use a chemical (pVPP) to eliminate this cloudiness and prevent deposits from forming in the bottle. So in order to obtain the benefits of xanthohumol, you need to drink artisanal beers with a strong hop content if possible (IPA, for example).
But the best way of benefiting from this cytoprotective compound (which we’ll undoubtedly be hearing more about in the future) is to take a hop flower supplement, standardised in xanthohumol, every day. It’s an ultra-modern solution (extracting the xanthohumol from the hop inflorescences is a major technological achievement) which draws on its ancient tradition of use and which avoids the oxidative effects of alcohol.
What benefits are offered by the supplement Xanthohumol?
Hop flower extract standardised in xanthohumol offers four main benefits, all of which are backed up by the scientific literature:
- It supports optimal cellular health and combats oxidative stress. Xanthohumol and the phenolic compounds present in hop cones are the most effective natural antioxidants in the plant kingdom. In 2014, Professor Wang and his team showed that at the same concentration, they had greater antioxidant activity than the antioxidants in green tea. A number of studies have also demonstrated the broad-spectrum chemopreventive properties of xanthohumol on cells (1-3): induction of detoxification enzymes, inhibition of angiogenesis and inflammatory signals, cytoprotective effects, induction of apoptosis, inhibition of free radicals and procarcinogens … (4).
- It helps lower blood cholesterol levels. In 2017, scientists discovered that xanthohumol promotes HDL cholesterol in the blood, helping to clear arteries and tissues of oxidised cholesterol and direct it towards the liver where it is broken down (5). In addition, the other natural compounds that give hop its characteristics disrupt the molecular mechanisms responsible for the initiation, progression and rupture of the atherosclerotic plaques that cause stroke.
- It’s a valuable aid against sleep problems and nervous agitation.. Did you know that in Belgium, where hops are widely grown, people are advised to put dried hop cones in their ears to improve their sleep? Research has indeed demonstrated that the compounds in hop produce similar effects to those of melatonin and can normalise circadian rhythms (6). Several studies have even shown a valerian and hop flower combination to be as effective for improving sleep as synthetic sleeping tablets (the famous benzodiazepines) but without causing the side-effects associated with these drugs (7).
- It reduces problems related to the menopause and pre-menopause. Hop flowers contain the most powerful phytooestrogen isolated to date: 8-Prenylnaringenin (8-11). It acts as a selective modulator of oestrogen receptors, helping to reduce discomfort associated with the menopause (12-13), such as hot flushes. In addition, xanthohumol is a powerful inhibitor of the bone resorption responsible for osteoporosis.
Other studies have demonstrated its ability to regulate fat metabolism (by improving lipid parameters) and to boost the body’s defences and vitality. By no means exhaustive, this list identifies xanthohumol as a substance of major interest in terms of protection and actively contributing to factors affecting recovery.
Where does xanthohumol come from?
Xanthohumol is extracted from the female cones of the hop plant, a climbing perennial which is added to beer to improve its taste, aroma, bitterness, frothy texture and preservation (14). It’s a chalcone-type antioxidant flavonoid, the only one of its kind, which is found solely in hop flowers. It’s therefore present in beer but in tiny amounts: due to the high temperatures used in the brewing process, it gets converted into another less powerful compound called isoxanthohumol. Some very hoppy beers (such as IPA) (15) contain more, as hops are added after brewing.
The hop has been regarded as a medicinal plant for centuries (16-17). Its use dates back to the monasteries of 8th century Europe(18), when it was used for its pharmacological properties, in particular for treating anxiety and sleep problems, for its benefits for the endocrine system and for its anti-tumour effects.
What are Xanthohumol’s mechanisms of action?
Xanthohumol’s mechanisms of action come from its extraordinarily high content of phenolic compounds. Recent studies show that regular consumption of these compounds can, in the long term, reduce the risk of many chronic health disorders such as cardiovascular disease (19). Phenols, and in particular, xanthohumol, exert modulatory effects in cells by interacting with a wide range of molecular targets of signalling pathways (mitogen-activated protein kinase, protein kinase C, detoxifying antioxidant enzymes …) (20). These effects translate into increased expression of certain cytoprotective genes,regulation of the normal cell cycle, inhibition of growth, an increase in apoptosis, inhibition of angiogenesis, as well as suppression of oxidative stress, a state of imbalance which impairs the structural and functional integrity of cell membranes (21). The role played by oxidative stress in the development of chronic diseases is now widely-documented in the scientific literature (22). Phenolic compounds can also influence the composition of gut microbiota and re-establish intestinal barrier function, thus modulating the chronic inflammation associated with metabolic diseases (23).
Following ingestion, phenolic compounds such as xanthohumol are absorbed, distributed to various tissues and then metabolised by the liver. A proportion undergo partial conversion by gut flora. (24).
How should Xanthohumol be taken?
The recommended dose is two capsules a day, to be taken with meals.
If you want to boost its effects on sleep, it’s worth knowing that hops acts synergistically with valerian (found in the natural formulation Advanced Sleep Formula). For improving hormone balance, it’s better to combine it with an extract of pumpkin seeds.
- Cell strengthening
- Technique that increases our cells’ natural defences against aggressive agents.
- Process whereby new blood vessels grow from existing ones.
- Physiological process of programmed cell death.
- Free radicals
- Unstable molecules that seek to bind to other atoms and cause chain reactions.
- A carcinogen precursor that can provoke, aggravate or sensitise cancer or its onset.
- Ceh, B., Kac, M., Kosir, I.J., Abram, V., 2007. Relationships between xanthohumol and polyphenol content in hop leaves and hop cones with regard to water supply and cultivar. International Journal of Molecular Sciences 8, 989-1000.
- Magalhaes, P.J., Guido, L.F., Cruz, J.M., Barros, A.A., 2007. Analysis of xanthohumol and isoxanthohumol in different hop products by liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry. Journal of Chromatography A 1150, 295-301.
- Miranda, C.L., Stevens, J.F., Helmrich, A., Henderson, M.C., Rodriguez, R.J., Yang, Y.H., Deinzer, M.L., Barnes, D.W., Buhler, D.R., 1999. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food and Chemical Toxicology 37, 271-285.
- Stevens, J.F., Page, J.E., 2004. Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 65, 1317-1330.
- J Nutr Biochem. 2017 Sep;47:29-34. doi: 10.1016/j.jnutbio.2017.04.011. Epub 2017 Apr 22. Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport. Hirata H, Uto-Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, Tsuchiya Y, Ikewaki K.
- Koetter, U., Schrader, E., Kaufeler, R., Brattstrom, A., 2007. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytotherapy Research 21, 847-851.
- Morin CM, Koetter U, et al. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005 Nov 1;28(11):1465-71.
- Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids.J Clin Endocrinol Metab 2000 Dec;85(12):4912-5.
- Milligan SR, Kalita JC, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer.J Clin Endocrinol Metab 1999 Jun;84(6):2249-52.
- Bowe J, Li XF, et al. The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. J Endocrinol. 2006 Nov;191(2):399-405.
- Nikolic D, Li Y, et al. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Drug Metab Dispos. 2004 Feb;32(2):272-9. Texte intégral : http://dmd.aspetjournals.org
- Heyerick A, Vervarcke S, et al. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas. 2006 May 20;54(2):164-75.
- A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Erkkola R, Vervarcke S, et al. Phytomedicine. 2010 May;17(6):389-96.
- Haseleu, G., Intelmann, D., Hofmann, T., 2009. Structure determination and sensory evaluation of novel bitter compounds formed from beta-acids of hop (Humulus lupulus L.) upon wort boiling. Food Chemistry 116, 71-81.
- Gerhauser, C., 2005a. Beer constituents as potential cancer chemopreventive agents. European Journal of Cancer 41, 1941-1954.
- Callemien, D., Jerkovic, V., Rozenberg, R., Collin, S., 2005. Hop as an interesting source of resveratrol for brewers: Optimization of the extraction and quantitative study by liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Journal of Agricultural and Food Chemistry 53, 424-429.
- Nagasako-Akazome, Y., Honma, D., Tagashira, M., Kanda, T., Yasue, M., Ohtake, Y., 2007. Safety evaluation of polyphenols extracted from hop bracts. Food and Chemical Toxicology 45, 1383-1392.
- Larson, A.E., Yu, R.R.Y., Lee, O.A., Price, S., Haas, G.J., Johnson, E.A., 1996. Antimicrobial activity of hop extracts against Listeria monocytogenes in media and in food. International Journal of Food Microbiology 33, 195-207
- Crozier, A., Jaganath, I.B., Clifford, M.N., 2009. Dietary phenolics: chemistry, bioavailability and effects on health. Natural Product Reports 26, 1001-1043.
- Hou, Z., Lambert, J.D., Chin, K.V., Yang, C.S., 2004. Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. Mutation ResearchFundamental and Molecular Mechanisms of Mutagenesis 555, 3-19.
- Makena, P.S., Chung, K.T., 2007. Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. Food and Chemical Toxicology 45, 1899- 1909.
- Soobrattee, M.A., Neergheen, V.S., Luximon-Ramma, A., Aruoma, O.I., Bahorun, T., 2005. Phenolics as potential antioxidant therapeutic agents: Mechanism and actions. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 579, 200-213.
- Anhe, F.F., Roy, D., Pilon, G., Dudonne, S., Matamoros, S., Varin, T.V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., Marette, A., 2015. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 64, 872-883.
- Khanal, R., Howard, L.R., Prior, R.L., 2014. Urinary excretion of phenolic acids in rats fed cranberry, blueberry, or black raspberry powder. Journal of Agricultural and Food Chemistry 62, 3987-3996
|Daily dose: 3 capsules
Number of doses per pack: 30
Amount per dose
|Extract of hop flower standardised to 10% xanthohumol
||150 mg |
|Other ingredients: acacia gum, white rice flour.
Directions for useXanthohumol
Adults. Take 3 capsules a day.
Each capsule contains 50mg of hop flower extract standardised to 10% xanthohumol.