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Welcome Shop by health concern Digestion and oro-gastro-intestinal health Super Curcuma + Bioperine
Super Curcuma + Bioperine
Digestion and oro-gastro-intestinal health Customer reviews
56.32 €(62.32 US$) is available
Description

Extract of black pepper (Piper nigrum) to maximise absorption of nutrients from food

  • Increases bioavailability of a number of micronutrients (2000% for curcumin)
  • Increases activity of digestive enzymes
  • Standardised to 95% natural piperine (the maximum available)
  • Increases thermogenesis
  • Stimulates the taste buds
Curcuma extract - 29 times more easily assimilated
  • Better absorption than traditional products.
  • Could have anti-tumoral and anti-inflammatory effects.
  • Traditionally used to stimulate digestion and biliary secretions.
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Super Curcuma + Bioperine
Super Curcuma + Bioperine Super Curcuma + Bioperine Super Curcuma + Bioperine
Bioperine 10 mg

We’re all familiar with the hotness of black pepper: it is due to the biological activity of several active compounds, in particular piperine.


What are the main effects of Bioperine?

Piperine is an alkaloid used for more than 20 years to maximise the bioavailability of nutrients. Black pepper is one of three essential natural ingredients used in the majority of Ayurvedic formulations.

It can increase absorption of selenium and vitamin C by up to 42% and 50% respectively. Below are just some of the many micronutrients where absorption can be improved by piperine:

  • curcumin (1);
  • iron (2);
  • resveratrol (3);
  • selenium;
  • vitamin B6;
  • β-Carotene;
  • extract of Boswellia serrata;
  • extract of Ginkgo biloba.
  • proteins in general.

Its effects are due to three distinct mechanisms of action:

  • Piperine helps increase intestinal activity of glycoprotein-P which is involved in the transport of many substances (including certain drugs) (4).
  • Piperine modifies the rate of glucurono-conjugation by reducing glucoronic acid content and inhibiting transferase activity (5). This mechanism enables foreign molecules to be solubilised for more effective elimination via urine.
  • Piperine also increases thermogenesis via the release of thermogenic hormones called catecholamines. This results in improved absorption of nutrients in the gut.


What are piperine’s other effects?

In addition to optimising bioavailability, piperine also offersdigestive benefits: it stimulates appetite and facilitates digestion (by increasing the activity of salivary amylase and trypsin, an enzyme in pancreatic juice which helps ‘break’ proteins (7)).

Piperine also helps increase the bioavailability of certain drugs such as ibuprofen (8). It therefore should not be taken at the same time as medication.


How is Bioperine produced?

Black pepper is a climbing vine that grows in forest habitats and equatorial climates: it can only be cultivated between the latitudes 15 degrees north and 15 degrees south.

Black pepper is picked when the berries (or drupes) start to turn red: it is at this stage that the amount of essential oil is at its peak. They are then deseeded, dried in the sun till the berries go black, then plunged into boiling water for several minutes. The heat ruptures the peppers’ cell walls and releases heat-resistant enzymes. The drupes are then dried in the open air before the outer coating is removed.

In the case of Bioperine, the piperine content is then increased so that it makes up around 95% of the natural black pepper extract.

It’s worth noting that while piperine can be synthesised in the laboratory using an enzyme called piperotransferase, Bioperine contains natural piperine extracts from black pepper drupes, unlike many piperine supplements on the market.


Can Bioperine be combined with other supplements?

Piperine potentiates the bioavailability of many supplements, but it is curcumin supplements, known for their powerful anti-inflammatory effects, that most benefit from being combined with Bioperine.

Curcumin’s bioavailability is actually very low because it is quickly metabolised in the liver. Thus taking 2g of curcumin will only produce a very slight increase in plasma concentrations. However, taking piperine at the same time produces a clear increase in curcumin levels, in the region of 2000%, within around 30 minutes of ingestion (6).

The mechanism responsible is inhibition of glucurono-conjugation: this slows down the breakdown of curcumin by the liver, considerably expanding its window of absorption.


References

1. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.

2. Majeed M, Vaidyanathan P et al. An Evaluation of Bioavailability Enhancement of Organic Elemental Iron with BioPerine® in Rabbits, Human Journals March 2016 Vol.:5, Issue:4

3. Johnson J, Nihal M et al. Enhancing the bioavailability of resveratrol by combining it with piperine, Mol Nutr Food Res. 2011 August ; 55(8): 1169–1176. doi:10.1002/mnfr.201100117.

4. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002 Aug;302(2):645-50.

5. Singh J, Dubey RK, Atal CK. Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content. J Pharmacol Exp Ther. 1986 Feb;236(2):488-93.

6. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.

7. Pruthi, J.S. (1980). Adv. Food Res., 4: 18-25

8. Venkatesh S, Durga KD, Padmavathi Y, et al. (2011) Influence of piperine on ibuprofen induced antinociception and its pharmacokinetics. Arzneimittelforschung 61(9): 506–9

CompositionBioperine 10 mg
Daily serving: 3 capsules
Number of servings per bottle: 30
Quantity per serving
Black pepper extract (Piper nigrum) standardised to 95% piperin 30 mg
Other ingredients: Acacia gum, rice bran.
Bioperine® - Sabinsa Corporation.

Each vegetarian capsule contains 10 mg of Bioperine®.
Directions for useBioperine 10 mg
Take one vegetarian Bioperine® capsule at the same time as your other supplements.
Pink powder pills

Part of Chinese and Ayurvedic systems of medicine for centuries, curcuma is traditionally used to stimulate digestion and treat digestive problems. It also has anti-oxidant and anti-inflammatory properties.

To improve uptake and absorption of curcumin, our dietary supplement Super Curcuma has been formulated to be 29 times more bioavailable than a traditional product, in order to take advantage of curcuma’s benefits with a recommended dose of 1 to 2 capsules a day.

What is Curcuma?

Originating from South Asia, curcuma, or turmeric, is a perennial herbaceous plant and a member of the ginger family. It is particularly valued for its rhizomes (the underground parts) from which the yellow-orange spice is obtained. Though the spice is primarily known as a culinary ingredient, curcuma also has a number of health benefits.

How does Super Curcuma work?

This supplement acts primarily by increasing bile secretion, thus facilitating digestion. As a result of its therapeutic benefits, curcuma has been the subject of numerous scientific studies. Researchers have succeeded in isolating the substances responsible for curcuma’s many benefits – curcuminoids – of which curcumin is the most abundant in curcuma and the best-documented in the scientific literature. Curcumin is recognised for its antioxidant and anti-inflammatory properties. As an antioxidant, curcuma helps combat free radicals, the reactive molecules responsible for cellular ageing.

What do studies say about Curcuma?

Given curcuma’s many properties, scientists are investigating its use in the prevention and treatment of a number of diseases. While results are still awaited, there is evidence to suggest curcuma may have a role in treating certain inflammatory diseases and arthritis. Other studies are also underway on the spice’s anti-cancer properties and potential for preventing some forms of cancer. Additional research is currently in progress which will hopefully reveal all curcuma’s secrets.

See also our article 5 good reasons to consume turmeric.

CompositionSuper Curcuma 500 mg
Daily dose : 2 capsules
Number of doses per pack : 30
Amount per dose
Meriva® (Soya phospholipids, extract of Curcuma longa) 1 000 mg
Other ingredients : Acacia gum.
Meriva®, Indena, Italy.
Directions for useSuper Curcuma 500 mg
Adults. Take one to two vegetarian capsules a day at mealtimes or as advised by your therapist.
Each capsule contains 500 mg of Meriva®. Contains soya derivatives.
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Super Curcuma + Bioperine
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