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Liquid liposomal glutathione supplement
Liquid liposomal glutathione supplement
0833Liquid liposomal glutathione supplement
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Liposomal Glutathione
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75.00 €(81.25 US$)
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Description
The most bioavailable form of glutathione (liposomal glutathione) combined with vitamin C for an optimal antioxidant effect
  • The body’s most powerful natural shield.
  • Reduced form (L-Glutathione), the only one biologically active in defence mechanisms.
  • Cutting-edge encapsulation process (liposomes) which protects the glutathione from gastric juices and maximises its absorption in the gut.
  • Liquid format offering one of the most powerful doses on the market (900mg of glutathione per measuring cap).
  • Rich in vitamin C which helps protect cells against oxidative stress.
  • Compound extensively-studied in the fields of anti-ageing and cellular integrity.
  • Glutathione levels decline with age.
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Molecule of antioxidant liposomal glutathione

Liposomal glutathione with optimal bioavailability - Benefits, risks

Liposomal Glutathione is a liquid liposomal glutathione supplement providing 900mg per measuring cap, the highest dose on the market.

Offered in its reduced from (the biologically active form), it acts synergistically with the antioxidant vitamin C to protect cells against oxidative stress. It benefits from innovative technology based on liposomal encapsulation which protects it from gastric juices, thus increasing its absorption in the gut.

This supplement forms part of our Anti-ageing category.

Definition of glutathione

Glutathione is a protein, more specifically, a tripeptide, which is produced by the body from three amino acids: glutamic acid, cysteine and glycine (1).

Dubbed ‘king of the antioxidants’ by scientists, it is our most powerful endogenous (produced by the body) protective compound.

Ubiquitous in living organisms, it occurs naturally in plants, fungi and animal cells.

What role does glutathione play?

Glutathione is involved in maintaining redox potential in cell cytoplasm. While its oxidised form has a pro-oxidant effect, its reduced form (GSH or L-glutathione) constitutes a first line defence for cells(2).

Though produced by virtually all the body’s cells including those of the nervous system, it is in the liver where the largest reserve of glutathione is found (3). This invaluable substance thus has remarkable liver-related detoxification properties, and is responsible for eliminating many ‘xenobiotic’ (foreign) toxins. Amongst others, it processes metabolites from tobacco, alcohol and therapeutic drugs.

In addition, its thiol grouping binds with heavy metal salts (mercury, lead, cadmium...) enabling them to be safely excreted by the body (4).

Glutathione is also a precursor of many detoxifying enzymes, including glutathione peroxidase responsible for neutralising waste products from cellular respiration or the process of ‘cell death’ (apoptosis) (5).

Glutathione is used intravenously in conventional medicine for haemodialysis patients at risk of anaemia, for metabolic problems (diabetes) and age-related neurodegenerative disorders.

It is also worth noting that glutathione levels decline with age, starting from around the age of 50. Low glutathione levels are often observed in patients with various neurological, visual and cardiovascular disorders (6-7).

What are the benefits of liposomal glutathione?

Taken orally, glutathione has inherently low bioavailability as it faces two key obstacles: the strong acidity of gastric juices and the action of a liver enzyme called gamma-glutamyltranspeptidase (GGT) which catalyses the first stage of its breakdown (8).

Liposomal glutathione is more effective than other forms as it benefits from innovative encapsulation technology. Here, the glutathione is contained within a casing made from phospholipids, liposomes, which protect it from digestive secretions and ensure it completes its journey to the intestinal barrier in its reduced form (9).

By way of example, scientists studying rats with rheumatoid arthritis demonstrated the superiority of liposomal glutathione over standard glutathione by measuring biomarkers of oxidative stress and inflammation. They observed a greater reduction in levels of rheumatoid factor, malondialdehyde and C-reactive protein (10).

3 raisons why Liposomal Glutathione is the best of its kind

SuperSmart’s Liposomal Glutathione stands out from other liposomal glutathione supplements in that it offers:

  1. an an exceptional dose of 900mg of glutathione per 10ml measuring cap, putting it among the most highly-dosed supplements on the market;
  2. a recognised synergy with vitamin C(700mg per dose), a well-known antioxidant which helps to maintain reduced glutathione concentrations at a cellular level. Studies have also identified low glutathione levels in individuals with inadequate vitamin C intakes (11) ;
  3. a convenient liquid form, with a pleasant exotic-fruit flavour, which you simply dilute in a drink.

Liposomal glutathione: any side-effects?

Current studies show that supplementing with liposomal glutathione causes very few side-effects – only a handful of cases of intestinal cramps and bloating have been reported.

Are there any risks associated with liposomal glutathione?

There is no mention in in vivo studies of any notable risk associated with liposomal glutathione supplementation. As a precautionary measure, however, women who are pregnant or breastfeeding and anyone suffering from a chronic disease should seek medical advice before starting to supplement with glutathione.

How should this liquid Liposomal Glutathione supplement be taken?

We recommend taking a daily dose of 1 capful of Liposomal Glutathione (10ml) diluted in a glass of water or fruit juice. Once opened, the bottle should be kept refrigerated for a maximum of 1 month.

What can you do to protect yourself from the harmful effects of oxidative stress?

Oxidative stress occurs when the body is no longer able to ‘mop up’ excess free radicals, pro-oxidant molecules which ‘rust’ our cells and make them age faster. This process is exacerbated by smoking, pollution, exposure to UV or ionising radiation, eating fried foods or those cooked at high temperatures, as well as engaging in high-intensity exercise(12).

To restore the right balance, make sure you eat plenty of highly-coloured fruits and vegetables (colour = high antioxidant content), reduce your exposure to pollutants, get enough sleep and minimise any sources of stress.

Two supplements to take alongside Liposomal Glutathione

If you want to do more to combat oxidative stress , then in addition to the vitamin C in Liposomal Glutathione, take vitamin E. This vitamin helps protect cells against oxidative stress by neutralising free radicals, thus protecting cell membranes from oxidative damage (13). Opt for tocotrienols, a powerful form of vitamin E (try, for example, Annatto Tocotrienols).

The rate at which your body ages is largely dependent on the condition of your DNA. In parallel with your liposomal glutathione supplementation, we’d also suggest taking a product rich in DNA-favourable nutrients (such as DNA Repair, which is rich in superoxide dismutase and zinc pidolate, both of which support normal DNA synthesis) (14).

Composition
Daily dose: 1 measuring cap (10 mL)
Number of doses per bottle: 20
Amount per dose
Reduced glutathione 900 mg
Vitamin C (in the form of sodium ascorbate and ascorbic acid) 700 mg
875% of Recommended Daily Intake for Vitamin C.
Other ingredients : water, glycerol, sunflower lecithin phosphatidylcholine, exotic fruit flavouring, liquid extract of sea buckthorn, steviol glycosides. Capsularis EMB-ETI0028.
Directions for use
Adults. Take 1 measuring capful (10ml) a day in a glass of water or fruit juice. Each 10ml measuring cap contains 900mg of reduced glutathione.

Attention: once opened, keep refrigerated for up to 1 month. Shake well before taking.

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References
  1. Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12. PMID: 26770075; PMCID: PMC4684116.
  2. Averill-Bates DA. The antioxidant glutathione. Vitam Horm. 2023;121:109-141. doi: 10.1016/bs.vh.2022.09.002. Epub 2023 Jan 13. PMID: 36707132.
  3. Vairetti M, Di Pasqua LG, Cagna M, Richelmi P, Ferrigno A, Berardo C. Changes in Glutathione Content in Liver Diseases: An Update. Antioxidants (Basel). 2021 Feb 28;10(3):364. doi: 10.3390/antiox10030364. PMID: 33670839; PMCID: PMC7997318.
  4. Jozefczak M, Remans T, Vangronsveld J, Cuypers A. Glutathione is a key player in metal-induced oxidative stress defenses. Int J Mol Sci. 2012;13(3):3145-3175. doi: 10.3390/ijms13033145. Epub 2012 Mar 7. PMID: 22489146; PMCID: PMC3317707.
  5. Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011 Oct 1;15(7):1957-97. doi: 10.1089/ars.2010.3586. Epub 2011 Apr 10. PMID: 21087145; PMCID: PMC3159114.
  6. Zhu Y, Carvey PM, Ling Z. Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res. 2006 May 23;1090(1):35-44. doi: 10.1016/j.brainres.2006.03.063. Epub 2006 May 2. PMID: 16647047; PMCID: PMC1868496.
  7. Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep;94(3):847-53. doi: 10.3945/ajcn.110.003483. Epub 2011 Jul 27. PMID: 21795440; PMCID: PMC3155927.
  8. Koenig G, Seneff S. Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk. Dis Markers. 2015;2015:818570. doi: 10.1155/2015/818570. Epub 2015 Oct 12. PMID: 26543300; PMCID: PMC4620378.
  9. Sinha R, Sinha I, Calcagnotto A, Trushin N, Haley JS, Schell TD, Richie JP Jr. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018 Jan;72(1):105-111. doi: 10.1038/ejcn.2017.132. Epub 2017 Aug 30. PMID: 28853742; PMCID: PMC6389332.
  10. Kadry MO. Liposomal glutathione as a promising candidate for immunological rheumatoid arthritis therapy. Heliyon. 2019 Jul 27;5(7):e02162. doi: 10.1016/j.heliyon.2019.e02162. PMID: 31384691; PMCID: PMC6661417.
  11. Waly MI, Al-Attabi Z, Guizani N. Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults. Prev Nutr Food Sci. 2015 Sep;20(3):198-203. doi: 10.3746/pnf.2015.20.3.198. Epub 2015 Apr 13. PMID: 26451357; PMCID: PMC4596346.
  12. Poljsak B. Strategies for reducing or preventing the generation of oxidative stress. Oxid Med Cell Longev. 2011;2011:194586. doi: 10.1155/2011/194586. Epub 2011 Dec 10. PMID: 22191011; PMCID: PMC3236599.
  13. Medina J, Gupta V. Vitamin E. [Updated 2023 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557737/
  14. Yan M, Song Y, Wong CP, Hardin K, Ho E. Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr. 2008 Apr;138(4):667-73. doi: 10.1093/jn/138.4.667. PMID: 18356318; PMCID: PMC4152237.

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