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Welcome Shop by health concern Sports and exercise L-Citrulline
L-Citrulline Supplement
L-Citrulline Supplement
0421L-Citrulline Supplement
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L-Citrulline
Sports and exercise
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27.00 €(32.61 US$) is available
Description
L-Citrulline is a natural amino-acid, precursor of arginine.
  • Offers considerable benefits for sportspeople keen to improve their performance.
  • Reduces cramps, soreness and muscle fatigue.
  • Increases the body's metabolic rate.
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100 g
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Fit, adult man, running

L-Citrulline Supplement - Arginine Precursor to Improve Muscle Activity

Extensively studied, citrulline offers considerable benefits for sportspeople keen to improve their performance. Like taurine, citrulline may help reduce the accumulation of ammonia in the body, so preventing cramp, soreness and muscle fatigue.

As a precursor of arginine, citrulline also promotes the production of nitric oxide, a compound with vasodilatory effects beneficial for muscle activity. To increase nitric oxide synthesis, other arginine supplements are available to buy at Supersmart such as the complexes Acetyl L-Carnitine Arginate and Arginine Silicate Inositol, and the specific form Arginine Alpha Ketoglutarate.

What is Citrulline?

Citrulline is a non-essential amino acid which the body produces from other nutrients under the right conditions. Together with ornithine and arginine, citrulline plays a particularly important role in what is called the urea cycle, in the liver.

In the course of this cycle, the toxic ammonium ion is converted into urea. Any disturbance to this cycle - which is essential for eliminating toxic metabolites of nitrogen - can result in a lethal build-up of proteins such as ammonia in the blood. Citrulline or arginine supplements are often recommended to treat such problems. Citrulline is also a precursor of the arginine produced during this cycle.

What benefits do studies show about L-Citrulline?

  • Increases levels of arginine more effectively than supplementation with arginine itself and improves nitrogen balance. Citrulline is not taken up by the liver but passes freely to the kidneys where it is metabolized into arginine.
  • Appears to have a beneficial effect on sickle cell anaemia.
  • Has a vasodilatory effect and increases nitric oxide production.
  • Decreases vascular smooth muscle cell proliferation and retards the progression of atherosclerotic lesions.
  • Increases the body's metabolic rate and aerobic performance and reduces muscle fatigue.
  • Stimulates the immune system.
  • Speeds up recovery from fatigue.

French researchers have recently shown that citrulline modulates muscle protein metabolism in old, undernourished rats. Preliminary studies suggest that it may directly stimulate protein synthesis.

Buy L-Citrulline to support sports performance.

Composition
Daily serving: 3 scoop
Number of servings per bottle: 14
Quantity per serving
L-citrulline 6.75 g

Each dosette contains 2.25 g of L-citrulline
Directions for use
Adults. Take one and a half scoop (3-4 g) once or twice a day as required, or as advised by your therapist.
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References
  1. Crenn, P., Messing, B., and Cynober, L. (2008). Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Nutr. Edinb. Scotl. 27, 328–339.
  2. Rougé C, Des Robert C, Robins A, Le Bacquer O, Volteau C, De La Cochetière M-F, et al. Manipulation of citrulline availability in humans. Am J Physiol Gastrointest Liver Physiol. nov 2007;293(5):G1061-1067.
  3. Moinard C, Nicolis I, Neveux N, Darquy S, Bénazeth S, Cynober L. Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. Br J Nutr. avr 2008;99(4):855 62.
  4. Grimble GK. Adverse gastrointestinal effects of arginine and related amino acids. J Nutr.

juin 2007;137(6 Suppl 2):1693S‑1701S.

  1. Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol Bethesda Md 1985. 15 août 2015;119(4):385 95.
  2. Thibault R, Flet L, Vavasseur F, Lemerle M, Ferchaud-Roucher V, Picot D, et al. Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study. Clin Nutr. déc 2011;30(6):807 11.
  3. Bouillanne O, Melchior J-C, Faure C, Paul M, Canoui-Poitrine F, Boirie Y, et al. Effets d’une complémentation de 3 semaines par la citrulline sur la masse maigre chez des patients âgés dénutris. Nutr Clin Métab. mars 2016;30(1):59 60.

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L-Citrulline
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