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Welcome Shop by health concern Tiredness and Lack of energy L-Selenomethionine
L-selenomethionine Supplement
L-selenomethionine Supplement
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L-Selenomethionine
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22.00 €(23.62 US$) in stock
Description
L-selenomethionine is a bioavailable from of selenium.
  • Protects DNA from oxidation more effectively than the sulphur in methionine.
  • Provides greater protection to the skin against UV damage.
  • Better absorbed and incorporated into the body's components better than any other form of selenium.
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Foods rich in selenium and a black board with the word 'Selenium'

L-Selenomethionine Supplement - Bioavailable Form of Selenium for

L-selenomethionine is a single chemical entity containing molecularly integrated selenium instead of sulphur in the methionine molecule - methionine being an essential amino acid. It is therefore a particularly safe form of selenium supplementation because, unlike other forms, it does not release inorganic selenium into the body. You can buy L-selenomethionine at Supersmart.

What is Selenomethionine?

Plants absorb selenium from the soil and convert it into organic forms. Selenium is therefore found as selenomethionine in wheat and other cereals and is thus also the main type of selenium present in foods. When ingested in this form, it replaces the sulphur in proteins, both in animals and humans. Selenomethionine is also the main form in which the body stores selenium. It is directly incorporated into proteins via metabolic pathways similar to those used by methionine. It is converted into selenocysteine, and then incorporated into selenoproteins.

The replacement of methionine by selenomethionine in the protein structure does not induce any functional changes. In fact, selenium in the protein structure protects DNA from oxidation more effectively than the sulphur in methionine. During photochemical reactions, the carbon-selenium bond is more easily broken compared to the carbon-sulphur bond. L-seleno-methionine preferentially accepts' the energy from light and provides greater protection to the skin against UV damage.

What is the benefit of using L-selenomethionine?

The form of selenomethionine that the body is able to use is L-selenomethionine. It is absorbed and incorporated into the body's components better than any other form of selenium. Its superior bioavailability has been demonstrated in several studies: selenium levels in red blood cells of individuals receiving selenomethionine increased by 100% after 16 weeks' supplementation, bringing more health benefits. Neither selenate nor selenite supplementation produced such an increase.

Composition
Daily serving: 1 tablet
Number of servings per bottle : 120

Quantity
per serving

L-selenomethionine (providing 200 mcg of elemental selenium) 480 mcg
Other ingredients: Acacia gum, fructo-oligosaccharides.

In this form - the most abundant in food – selenium is rapidly and completely absorbed by the gastro-intestinal system.
Directions for use
Take one tablet a day with food.
5
4.9 /5 8 reviews
Description
5
4.8 / 5
Quality
5
4.8 / 5
Value for money
5
4.7 / 5

Reviews 8
Excellent
88 %
Great
12%
Average
0%
Poor
0%
Bad
0%

Alain Chaussy
5
rapport/qualité prix:top!
marie
5
un basique de la sante
BOURDIN
5
Un complément efficace pour soutenir les organismes fatigués et (ou) âgés.
marie
4
basique absolu pour la sante
SUZANNE BONO
5
Super produit
marie
5
un de mes basiques
SUZANNE BONO
5
Très satisfaite de ce produit que je prends régulièrement.
BROUILLET Simone
5
Excellent anti-oxydant et l'alimentation actuelle ne fournit pas assez de selenium
References
  1. National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 105024, L-selenomethionine. Retrieved May 6, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/L-selenomethionine.
  2. Schrauzer GN. Selenomethionine: a review of its nutritional significance, me-tabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6. doi: 10.1093/jn/130.7.1653. PMID: 10867031.
  3. Bera S, De Rosa V, Rachidi W, Diamond AM. Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemopreven-tion?. Mutagenesis. 2013;28(2):127-134. doi:10.1093/mutage/ges064
  4. Overvad K, Thorling EB, Bjerring P, Ebbesen P. Selenium inhibits UV-light-induced skin carcinogenesis in hairless mice. Cancer Lett. 1985 Jun;27(2):163-70. doi: 10.1016/0304-3835(85)90105-3. PMID: 4005828.
  5. Hall JA, Van Saun RJ, Bobe G, Stewart WC, Vorachek WR, Mosher WD, Ni-chols T, Forsberg NE, Pirelli GJ. Organic and inorganic selenium: I. Oral bioa-vailability in ewes. J Anim Sci. 2012 Feb;90(2):568-76. doi: 10.2527/jas.2011-4075. Epub 2011 Sep 30. PMID: 21965451.
  6. Schrauzer GN. Selenomethionine: a review of its nutritional significance, me-tabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6. doi: 10.1093/jn/130.7.1653. PMID: 10867031.
  7. Fairweather-Tait SJ, Collings R, Hurst R. Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr. 2010 May;91(5):1484S-1491S. doi: 10.3945/ajcn.2010.28674J. Epub 2010 Mar 3. Erratum in: Am J Clin Nutr. 2010 Oct;92(4):1002. PMID: 20200264.
  8. Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2012;16(7):705-743. doi:10.1089/ars.2011.4145
  9. Arteel GE, Sies H. The biochemistry of selenium and the glutathione system. Environ Toxicol Pharmacol. 2001 Sep;10(4):153-8. doi: 10.1016/s1382-6689(01)00078-3. PMID: 21782571
  10. Combs GF Jr, Midthune DN, Patterson KY, et al. Effects of se-lenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Am J Clin Nutr. 2009;89(6):1808-1814. doi:10.3945/ajcn.2008.27356
  11. Moslemi MK, Tavanbakhsh S. Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med. 2011;4:99-104. Published 2011 Jan 23. doi:10.2147/IJGM.S16275
  12. Tortelly Costa VD, Melo DF, Matsunaga AM. The Relevance of Se-lenium to Alopecias. Int J Trichology. 2018;10(2):92-93. doi:10.4103/ijt.ijt_37_17
  13. Shreenath AP, Ameer MA, Dooley J. Selenium Deficiency. [Updated 2021 Dec 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Pu-blishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482260/
  14. MacFarquhar JK, Broussard DL, Melstrom P, et al. Acute selenium toxi-city associated with a dietary supplement. Arch Intern Med. 2010;170(3):256-261. doi:10.1001/archinternmed.2009.495
  15. MacFarquhar JK, Broussard DL, Melstrom P, et al. Acute selenium toxi-city associated with a dietary supplement. Arch Intern Med. 2010;170(3):256-261. doi:10.1001/archinternmed.2009.495
  16. Amraoui W, Adjabi N, Bououza F, et al. Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats. Toxicol Res. 2018;34(3):231-239. doi:10.5487/TR.2018.34.3.231
  17. Singh U, Devaraj S, Jialal I. Vitamin E, oxidative stress, and inflamma-tion. Annu Rev Nutr. 2005;25:151-74. doi: 10.1146/annurev.nutr.24.012003.132446. PMID: 16011463.
  18. Marreiro DD, Cruz KJ, Morais JB, Beserra JB, Severo JS, de Oliveira AR. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel). 2017 Mar 29;6(2):24. doi: 10.3390/antiox6020024. PMID: 28353636; PMCID: PMC5488004.
  19. Maares M, Haase H. Zinc and immunity: An essential interrelation. Arch Biochem Biophys. 2016 Dec 1;611:58-65. doi: 10.1016/j.abb.2016.03.022. Epub 2016 Mar 26. PMID: 27021581.
  20. Park H, Kim CW, Kim SS, Park CW. The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata pa-tients who had a low serum zinc level. Ann Dermatol. 2009;21(2):142-146. doi:10.5021/ad.2009.21.2.142

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