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L-selenomethionine Supplement
L-selenomethionine Supplement
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L-Selenomethionine
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Description
The most bioavailable form of selenium (L-selenomethionine)
  • Organic form absorbed better by the body than standard inorganic forms (selenite and selenium sulphide).
  • Helps protect cells against oxidative stress.
  • Supports normal immune system function.
  • Plays a role in spermatogenesis and thyroid function
  • Helps maintain healthy hair and nails
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Foods rich in selenium and a black board with the word 'Selenium'

L-Selenomethionine Supplement - Bioavailable Form of Selenium for

L-Selenomethionine is a natural selenium supplement with optimal efficacy and bioavailability. Its organic form (selenomethionine) obtained from yeast extracts offers superior absorption than classic inorganic selenium supplements.

Essential to life, this trace-element plays a role in, amongst others, fighting oxidative stress, supporting normal immune function and maintaining healthy hair and nails. It thus remains a weapon of choice during periods of fatigue and convalescence.

What is selenomethionine?

Selenomethionine is the most abundant form of selenium in our diet. It’s primarily found in plant-source foods (grains, soya, brewer’s yeast …). When grown in selenium-rich soil, plants are able to capture this mineral and metabolise it into organic derivatives (1).

Chemically, selenomethionine corresponds to the selenium analogue of methionine, one of the 22 proteinogenic amino acids. In other words, methionine shares the same molecular formula as selenomethionine, but its sulphur atom is replaced by a selenium atom. This biochemical proximity means selenomethionine is able to integrate certain proteins in the body called selenoproteins. In this form, it can be durably stored in tissues, particularly muscle tissue, and released as necessary to meet the body’s needs.

The replacement of methionine by selenomethionine in the protein structure does not cause any notable change in function, and may even present some advantages. For example, compared with sulphur, selenium may offer additional protection against oxidative processes(3). In addition, during photochemical reactions, the carbon-selenium bond is more easily broken than the carbon-sulphur one: selenomethionine thus reacts better to the energy of ultraviolet light (4).

What’s the best form of selenomethionine?

First of all, it’s worth noting that organic selenium chelated with amino acids (such as selenomethionine or selenocysteine) is is better assimilated than inorganic selenium salts (such as selenite or selenium sulphide) (5). Selenomethionine displays an average absorption rate of around 90%, compared with 50%-60% for inorganic forms.

To be fully bioassimilated, a selenium supplementat needs to contain a form naturally ingested through food. The L isomer of selenomethionine, better-known as L-selenomethionine, is the form most commonly found in our diet (6). Perfectly-adapted to human metabolism, it offers superior bioavailability and produces a rapid increase in blood selenium levels(7).

What are the benefits of selenium?

According to EFSA-approved claims, selenium helps to:

  • maintain normal immune system function: several studies have demonstrated the role played by selenoproteins in the activation, proliferation and differentiation of immune cells, as well as in modulating immunity(8);
  • protect cells against oxidative stress: as a cofactor of glutathione peroxidase, a redox enzyme, selenium supports the neutralisation of free radicals that attack cell membranes (9). Conversely, a lack of selenium may exacerbate the toxicity of by-products of redox reactions;
  • maintain normal thyroid function: the thyroid is the organ with the highest selenium content in the body. This trace-element regulates thyroid hormone production, specifically triiodothyronine (T3) (10) ;
  • support normal spermatogenesis: selenium is particularly involved in the metabolism of testosterone and in sperm motility (11) ;
  • maintain healthy hair and nails: as a result of its antioxidant properties, selenium helps to make the hair stronger and shinier (12), and the nails beautiful and glossy.

How is selenium deficiency recognised?

Though relatively rare in western Europe, selenium deficiency may still affect between 500 million and 1 billion people worldwide, with huge variability depending on socioeconomic status (13).

It normally presents as severe fatigue, moodiness or irritability, greater susceptibility to infections and an imbalance of the thyroid gland. In critical cases, it can cause heart muscle and joint damage.

Selenium deficiency is more common in countries with selenium-depleted soil, such as New Zealand and China. It can also occur in people receiving parenteral nutrition without added selenium.

Does supplementation pose any risk of excessive selenium intake?

Though beneficial when ingested in reasonable amounts, selenium is toxic in high doses. Intakes above 1000 mcg/day cause, in particular, brittle nails, abnormally weak hair shafts, skin infections, garlicky breath, diarrhoea, vomiting and increased fatigue. Supplementing with too high a dose of selenium without prior medical advice is often the cause (14).

Providing a dose of 200mcg of selenium per tablet, the antioxidant selenium supplement L-Selenomethionine is below the upper safe limit of 300mcg/day for adults set by the EFSA. Keeping to the suggested dose (of 1 tablet a day) will thus provide you with a safe, sufficient and effective intake of selenium.

Which foods are rich in selenium?

Selenium is a trace-element integral to living things. In terms of animal-origin foods, eggs, kidneys, fish and seafood are all good sources. In the plant kingdom, it’s found at significant levels in Brazil nuts, garlic and mushrooms (15).

It’s also found in vegetables and whole grains provided they’re grown in soil with substantial selenium levels.

Synergistic supplements to combine with selenomethionine

By also helping to protect cells against oxidative stress, vitamin E acts symbiotically with selenium to maintain cell membranes by participating in redox reactions (16-17). Concurrent supplementation with Natural E 400, a natural-source vitamin E supplement, is thus strongly recommended.

Involved in more than 300 enzymatic reactions, zincplays a role in normal DNA synthesis and immune system function as well as in protecting cells against oxidative stress(18-19). It also helps to maintain healthy hair and nails (20). Combining L-Selenomethionine with L-OptiZinc® (which contains both zinc and methionine for enhanced retention) forms a powerful and popular duo for stimulating immunity.

Composition
Daily serving: 1 tablet
Number of servings per bottle : 120

Quantity
per serving

L-selenomethionine (providing 200 mcg of elemental selenium) 480 mcg
Other ingredients: Acacia gum, fructo-oligosaccharides.

In this form - the most abundant in food – selenium is rapidly and completely absorbed by the gastro-intestinal system.
Directions for use
Take one tablet a day with food.
5
4.9 /5 8 reviews
Description
5
4.8 / 5
Quality
5
4.8 / 5
Value for money
5
4.7 / 5

Reviews 8
Excellent
88 %
Great
12%
Average
0%
Poor
0%
Bad
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Alain Chaussy
5
rapport/qualité prix:top!
marie
5
un basique de la sante
BOURDIN
5
Un complément efficace pour soutenir les organismes fatigués et (ou) âgés.
marie
4
basique absolu pour la sante
SUZANNE BONO
5
Super produit
marie
5
un de mes basiques
SUZANNE BONO
5
Très satisfaite de ce produit que je prends régulièrement.
BROUILLET Simone
5
Excellent anti-oxydant et l'alimentation actuelle ne fournit pas assez de selenium
References
  1. National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 105024, L-selenomethionine. Retrieved May 6, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/L-selenomethionine.
  2. Schrauzer GN. Selenomethionine: a review of its nutritional significance, me-tabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6. doi: 10.1093/jn/130.7.1653. PMID: 10867031.
  3. Bera S, De Rosa V, Rachidi W, Diamond AM. Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemopreven-tion?. Mutagenesis. 2013;28(2):127-134. doi:10.1093/mutage/ges064
  4. Overvad K, Thorling EB, Bjerring P, Ebbesen P. Selenium inhibits UV-light-induced skin carcinogenesis in hairless mice. Cancer Lett. 1985 Jun;27(2):163-70. doi: 10.1016/0304-3835(85)90105-3. PMID: 4005828.
  5. Hall JA, Van Saun RJ, Bobe G, Stewart WC, Vorachek WR, Mosher WD, Ni-chols T, Forsberg NE, Pirelli GJ. Organic and inorganic selenium: I. Oral bioa-vailability in ewes. J Anim Sci. 2012 Feb;90(2):568-76. doi: 10.2527/jas.2011-4075. Epub 2011 Sep 30. PMID: 21965451.
  6. Schrauzer GN. Selenomethionine: a review of its nutritional significance, me-tabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6. doi: 10.1093/jn/130.7.1653. PMID: 10867031.
  7. Fairweather-Tait SJ, Collings R, Hurst R. Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr. 2010 May;91(5):1484S-1491S. doi: 10.3945/ajcn.2010.28674J. Epub 2010 Mar 3. Erratum in: Am J Clin Nutr. 2010 Oct;92(4):1002. PMID: 20200264.
  8. Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2012;16(7):705-743. doi:10.1089/ars.2011.4145
  9. Arteel GE, Sies H. The biochemistry of selenium and the glutathione system. Environ Toxicol Pharmacol. 2001 Sep;10(4):153-8. doi: 10.1016/s1382-6689(01)00078-3. PMID: 21782571
  10. Combs GF Jr, Midthune DN, Patterson KY, et al. Effects of se-lenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Am J Clin Nutr. 2009;89(6):1808-1814. doi:10.3945/ajcn.2008.27356
  11. Moslemi MK, Tavanbakhsh S. Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med. 2011;4:99-104. Published 2011 Jan 23. doi:10.2147/IJGM.S16275
  12. Tortelly Costa VD, Melo DF, Matsunaga AM. The Relevance of Se-lenium to Alopecias. Int J Trichology. 2018;10(2):92-93. doi:10.4103/ijt.ijt_37_17
  13. Shreenath AP, Ameer MA, Dooley J. Selenium Deficiency. [Updated 2021 Dec 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Pu-blishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482260/
  14. MacFarquhar JK, Broussard DL, Melstrom P, et al. Acute selenium toxi-city associated with a dietary supplement. Arch Intern Med. 2010;170(3):256-261. doi:10.1001/archinternmed.2009.495
  15. MacFarquhar JK, Broussard DL, Melstrom P, et al. Acute selenium toxi-city associated with a dietary supplement. Arch Intern Med. 2010;170(3):256-261. doi:10.1001/archinternmed.2009.495
  16. Amraoui W, Adjabi N, Bououza F, et al. Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats. Toxicol Res. 2018;34(3):231-239. doi:10.5487/TR.2018.34.3.231
  17. Singh U, Devaraj S, Jialal I. Vitamin E, oxidative stress, and inflamma-tion. Annu Rev Nutr. 2005;25:151-74. doi: 10.1146/annurev.nutr.24.012003.132446. PMID: 16011463.
  18. Marreiro DD, Cruz KJ, Morais JB, Beserra JB, Severo JS, de Oliveira AR. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel). 2017 Mar 29;6(2):24. doi: 10.3390/antiox6020024. PMID: 28353636; PMCID: PMC5488004.
  19. Maares M, Haase H. Zinc and immunity: An essential interrelation. Arch Biochem Biophys. 2016 Dec 1;611:58-65. doi: 10.1016/j.abb.2016.03.022. Epub 2016 Mar 26. PMID: 27021581.
  20. Park H, Kim CW, Kim SS, Park CW. The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata pa-tients who had a low serum zinc level. Ann Dermatol. 2009;21(2):142-146. doi:10.5021/ad.2009.21.2.142

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