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Blog Vision & Hearing

AMD: a large-scale study explores an unexpected role for melatonin

14/10/2026

Best known for its role in the sleep-wake cycle, melatonin may also affect eyesight. A large-scale study of medical records has recently revealed an unexpected association between regular melatonin intake and a reduced risk of developing AMD.

📌︎ Key takeaways
  • ✓A large-scale US study investigated the link between melatonin and age-related macular degeneration (AMD) using data from over 180,000 medical records.
  • ✓Regular use of melatonin was associated with a lower risk of developing AMD.
  • ✓In people already living with dry AMD, it was also associated with a lower risk of progression to exudative AMD.
  • ✓This observational study provides promising scientific evidence, but does not allow us to conclude that there is a cause-and-effect relationship.
  • ✓Melatonin is no substitute for regular eye check-ups or prescribed treatments, but it represents an interesting avenue of research into retinal ageing.

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