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Welcome Shop by health concern Anti-ageing Senolytic Complex + DNA Repair
Senolytic Complex + DNA Repair
Anti-ageing Customer reviews
117.00 €(129.92 US$) is available
Description
Enhanced formulation for repairing DNA.
  • Anti-mutagenic activity.
  • Formulated to combat ageing.
  • Combines a number of antioxidants that protect against oxidative stress.
Senolytics: a revolutionary formula for destroying the senescent cells responsible for aging
  • Has a rapid and long-lasting rejuvenating effect on the whole body.
  • Encourages self-destruction of the senescent cells responsible for aging and age-related health issues (muscle weakness, cognitive decline, cardiovascular problems, chronic inflammation…).
  • Rich in fisetin, the most powerful natural senolytic compound identified.
  • Contains quercetin phytosome, 20 times more absorbable than standard quercetin.
  • Draws on the very latest scientific research (senotherapy).
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Senolytic Complex + DNA Repair
Senolytic Complex + DNA Repair Senolytic Complex + DNA Repair Senolytic Complex + DNA Repair
DNA RepairAchieving or maintaining optimal health depends first and foremost on good cellular health. The main focus of current scientific research into extending life expectancy is almost certainly the protection and repair of damaged DNA. DNA Repair is a completely new formula that both protects - and increases our ability to repair - DNA, the carrier of genetic information.

Our cells multiply every day but the fragile DNA within each cell is vulnerable to damage by a range of factors including free radical attack and lack of vitamins, minerals and enzymes ... When DNA is damaged, cell function becomes impaired, potentially to the point where cells are unable to self-replicate and divide.
In fact, DNA suffers damaging events on a daily basis, but when entire generations of cells are affected, it compromises the vital reserves of tissues and organs, dramatically accelerating the ageing process
Current scientific thinking supports the theory that it is the gradual destruction of DNA which leads first to accelerated ageing and then to overall impairment of the body, with a decline in capacity for self-repair that becomes increasingly ineffective with age. Self-replication of cells thus takes place in a damaged or corrupted form and cell division subsequently ceases to occur.
This degenerative process can, however, be impeded with selective use of nutritional supplements. DNA Repair contains specific plant extracts, vitamins, minerals and antioxidants that act synergistically to support DNA repair processes.

Exclusive and truly effective formulation

AC-11®
is a patented, water-soluble plant extract ofUncaria tomentosa. A number of clinical studies have confirmed the potency of its carboxyl alkyl esters (CAE) in repairing cell DNA damage, whether caused by UV exposure or any other source of oxidative stress. • What’s more, the benefits of taking AC-11® extend well beyond those related to repair of damaged DNA. Indeed, the many studies conducted on this product show that it:
    - boosts the immune system by supporting lymphocytes (increasing their lifespan);
    - stimulates production of type 3 collagen (in the skin);
    - repairs muscle tissue;
    - improves inflammatory response by normalising NF-kB which is a nuclear transcription factor governing the genetic code of a number of proteins that regulate cell apoptosis and the mechanisms linked to inflammation and cell growth.
• AC-11®, standardised in CAE, is thus without doubt one of the most active anti-ageing agents, complemented by other antioxidant and reparative substances.
The broccoli extractin DNA Repair is standardised to 10% sulforaphane. This widely-studied glucosinolate is an enzyme activator. Comparable to I3C (indole-3-carbinol), it is able to neutralise carcinogens by activating so-called phase 2 liver detoxification enzymes. It can also protect against certain chemically-induced cancers such as colon and prostate cancer. It is a major protector of cell integrity.
Boosting its action, is an extract of wasabi or horseradish , added for its content in various glucosinolates which play a role in regulating liver enzymes, preserving DNA and improving the inflammatory response.
Arabinogalactansextracted from larch (Larix occidentalis) impede inflammatory processes and are highly effective at supporting the immune system by increasing NK cells (hence their use in liver metastases) and lymphokines, thus combatting the destruction of cell DNA by various aggressors.
Curcuma longa, and particularly the curcuminoids it contains, are among the most effective substances for preserving cellular DNA and act as powerful detoxification agents. All the research on curcuma confirms it has general antioxidant properties, protects against cancer and reduces inflammatory processes, and that supplementing with it reduces mutagenic elements
SOD-Gliadins complex is the only stable, oral form of SOD (superoxide dismutase). This melon extract combined with a wheat protein (gliadin) protects DNA from oxidative damage.
AuroraBlue® is an exclusive powder complex of Vaccinium berry species (alaskaense, ovaliforium, membranaceum, uliginosum, cespitosum) which is rich in anthocyanins, proanthocyanidins, flavonols (quercetin, myricetin, fisetin, catechins), stilbenes, vitamins (C and K), minerals and oligo-elements…
The excellent nutritional profile of this unique complex and the substances it provides :
    • enables healthy cell replication to take place;
    • combats inflammatory and oxidative processes, thus protecting DNA from attack at a cellular level.
Chlorophyll, in the form of sodium copper salt, complements these other substances by combatting free radicals and by binding to certain toxic chemicals, thus aiding their elimination from the body.

Last but not least, this product also contains vitamin B9 in its most bioavailable form (Quatrefolic®), vitamin B12 (methylcobalamine) and zinc pidolate - three essential catalysts that participate in redox and methylation of DNA.

This complex can be taken for long periods, either on its own or combined with cycloastragenol which also stimulates DNA repair by activating telomerase, or even with pyrroloquinoline quinone (PQQ) which protects mitochondrial DNA.
CompositionDNA Repair
Daily dose: 2 capsules
Number of doses per pack: 30
Amount per dose
AC-11® (proprietary extract of Uncaria tomentosa standardised to 8% carboxy alkyl esters) 250 mg
Extract of broccoli standardised to 10 % sulforaphane glucosinolate 150 mg
Extract of larch standardised to 85 % arabinogalactans 125 mg
Extract of Curcuma longa standardised to 95 % curcuminoids 100 mg
SOD-Gliadins complex combining extract of melon (Cucumis melo L) with extract of wheat (Triticum vulgare) on a plant maltodextrin base providing 500 IU (NBT units) of SOD 100 mg
Sodium copper salt of chlorophyll (including 4mg of copper, ie, 400% AJR) 100 mg
AuroraBlue® (Proprietary powder blend of Vaccinium alaskaense, Vaccinium ovaliforium, Vaccinium membranaceum, Vaccinium uliginosum, Vaccinium cespitosum) 100 mg
Extract of wasabi 4:1 50 mg
Zinc pidolate (including 3 mg zinc, ie 20 % AJR) 15 mg
Methylcobalamine 200 mcg
Quatrefolic® acid (6S)-5-methyltetrahydrofolic acid (from 200 mcg of 54-59% glucosamine salts and (6S)-5-methyltetrahydrofolic acid) 108 mc
Other ingredients : Acacia gum, rice flour.
Quatrefolic®, Gnosis, Italy. GliSODin®, Isocell, France.
AuroraBlue®, Denali, USA. AC-11® is a trade mark of Optigenex Inc., USA. (Patente europeia N.º 1,485,114 A2, 1,096,943 B1)
Directions for useDNA Repair
Adults. Take two capsules a day.
Senolytic Complex

Senolytic Complex is a completely new ‘senolytic’formulation for fighting the aging process, based on the very latest discoveries in anti-aging medicine.
The term ‘senolytic’, recently coined by the scientific community, describes the ability to eliminate senescent cells (ie, aged cells), the presence of which has been identified in recent years as being, along with oxidative stress and telomere shortening, one of the causes of aging. Since there was previously no way of preventing or slowing down this process, Senolytic Complex constitutes a truly revolutionary treatment.

The formulation contains the most powerful, natural, senolytic compounds identified to date: quercetin (in a form 20 times more bioavailable than standard quercetin), theaflavin, and most importantly, fisetin, an extraordinary flavonoid that’s really setting the scientific community alight.

Who is Senolytic Complex aimed at?

Senolytic Complex is for anyone over 40, whether as a course of treatment, or as long-term supplementation, to eliminate senescent cells and prevent their reappearance.

It is particularly recommended for the following groups of people:

  • those who wish to extend their life expectancy;
  • those keen to maintain good physical condition and optimal health as they age;
  • those who are already suffering from age-related problems (muscle weakness, cardiovascular disorders, vision and hearing impairment, cognitive decline, osteoporosis …) and those who wish to reduce their risk of developing them.

How does Senolytic Complex work?

The discovery of senescent cells invading the body

In 2014, researchers achieved a major advance in the fight against aging. They identified old, worn-out cells in the tissues of subjects aged over 40. Termed ‘senescent’, these zombie-like cells (1) are deformed and unable to divide, and are distributed throughout the body’s tissues. Though no longer functioning normally, they are not eliminated and thus accumulate pathologically.

These cells are rare in young people but increase with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, kidneys and skin (2-3).

Their dramatic effects on healthy cells and on the body

Unfortunately, senescent cells do not just take over, they also impede the activity of neighbouring healthy cells by continually releasing pro-inflammatory cytokines (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) into the extracellular environment (4-7). These substances are really distress calls: they signal to other cells the advanced state of deterioration in which they find themselves, but at the same time, they significantly affect the function of neighbouring healthy cells (8)!

Over the last three years, a number of studies have shown that the level of senescent cells in the body is directly linked to the pace of aging (9) and the development of age-related health problems. Even a small amount of these cells is enough to wreak havoc in tissues(10) and induce the onset of many age-related problems: systemic inflammation, arthritis, atherosclerosis, chronic diseases (11), sarcopenia, cataracts, insulin resistance, vascular hypo-reactivity (12) (13) ...

How can we get rid of these ‘parasitic’ cells?

These cells normally destroy themselves in a process called apoptosis, in order to avoid damaging the body. However, this mechanism does not always work in which case the senescent cells continue to parasitize the body and cause chaos all around them.(14).

Fortunately, researchers have identified several compounds that are specifically capable of repairing this defective mechanism and bringing about the self-destruction of these senescent cells. These extraordinary compounds are called ‘senolytics’.

The first study to identify senolytics was published in 2015 in the well-known scientific journal Aging Cell (15). Quercetin, a natural flavonol compound, combined with an anti-cancer drug, was found to dramatically decrease both the number of senescent cells and secretion of pro-inflammatory factors in the organism studied. In just five weeks, this combination resulted in a significant reduction in mortality and physical deterioration.

Dozens of studies have since identified natural compounds with the same properties (16-17). This has led to the development of a revolutionary new therapy, senolytic treatment, which is able to selectively destroy senescent cells and thus reduce the severity of age-related diseases, increase resilience and longevity, and delay the effects of aging.

The treatment is essentially a massive ‘spring clean’, after which healthy cells regain control of the body and again function at full capacity. It represents a significant advance in the fight against aging.

What is in Senolytic Complex?

Senolytic Complex contains three exceptional senolytic compounds (fisetin, quercetin and theaflavin) and three other anti-aging compounds of interest (vitamin C, nicotinamide mononucleotide and bromelain).

How does Senolytic Complex work?

How does Senolytic Complex work?

Fisetin, the most powerful senolytic.

Fisetin is part of the large family of flavonoids, a group of polyphenol antioxidants (18) found in small amounts in strawberries, mangos and certain plants. Of all the flavonoids tested, it was shown to be the most effective at reducing senescent cells (19).

It helps extend longevity (20-21) and reduce markers of senescence in humans. Its hydrophobic nature means it penetrates cells easily via cell membranes (22) and subsequently promotes the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins. One of its specific abilities is to reduce the fraction of senescent cells in the immune system (T lymphocytes and NK cells), thus increasing its beneficial effect, since immune cells are important for clearing out senescent cells (23). In addition, it inhibits the activity of several inflammatory cytokines such as TNFα, IL-6, and the transcription factor NF-Κb, and also offers anti-hyperlipidaemia effects (24).

It is supplied at a dose of 100mg a day (an average 0.4mg a day is consumed from the diet (25)).

For more information on fisetin and its senolytic properties, see: Fisetin is a senotherapeutic that extends health and lifespan.

Quercetin and theaflavin, two other major senolytic compounds

Since senescent cells use different mechanisms to resist programmed cell death (26-27), it’s important that other senolytic compounds are included in the formulation. Quercetin and theaflavin have been selected as two natural senolytics highlighted in the research.

Like fisetin, quercetin is also a member of the flavonoid family. It is extracted from Styphnolobium japonicum, the ‘Japanese pagoda tree’ or ‘honey tree’, and is delivered in a phytosome form which maximises its absorption into the bloodstream. It is recognised as being a benchmark senolytic, in combination with theaflavin, a polyphenol from black tea.

Bromelain, NMN and vitamin C

Senolytic Complex is enhanced by the addition of anti-aging substances that work in symbiosis, such as nicotinamide mononucleotide, an element essential for cellular energy production and longevity of sirtuin proteins, bromelain, an enzyme which actively opposes systemic inflammation, and vitamin C (in its non-acid form), a potent antioxidant that supports the immune system.

How should Senolytic Complex be taken?

Senolytic Complex can either be used as an annual or quarterly treatment (28), or taken continuously, according to your needs. The capsules should be taken at mealtimes.

Senolytic treatment (senotherapy) can be undertaken as a three-step programme:

  1. Eliminate senescent cells from your body (even a partial cleansing appears to bring benefits (29)) with the aid of Senolytic Complex.
  2. Prevent the development of new senescent cells by improving your lifestyle, protecting yourself against the factors that cause cellular ageing, and strengthening both your DNA repair systems (with the aid of DNA Repair) and antioxidant systems (with the aid ofResveratrol synergy). With its vitamin C and bromelain, Senolytic Complex plays an active role in preventing the reappearance of senescent cells. A number of mechanisms are responsible for their development but two appear to be dominant: high inflammation levels and oxidative stress.
  3. Stimulate and boost the immune system so that it too can help clear out senescent cells (with the aid of an immunostimulant mushroom extract).

Attention: fisetin should not be taken in conjunction with antivitamin K drugs, which are commonly-used oral anticoagulants (30).

The very latest research shows that a formulation such as this can produce powerful rejuvenating effects, improve the condition of those affected by age-related health problems, slow down the aging process and extend lifespan.
Exceptional benefits which place this dietary supplement right at the top of anti-aging nutrition and which should come as welcome news for very many people …

Written : Avril 2019

Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place

References

  1. Swanson E.C., Manning B., Zhang H., Lawrence J.B. Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence. J Cell Biol. 2013;203(6):929–942.
  2. Tchkonia T., Morbeck D.E., von Zglinicki T., van Deursen J., Lustgarten J., Scrable H. Fat tissue, aging, and cellular senescence. Aging Cell. 2010;9:667–684
  3. Tchkonia T., Morbeck D.E., von Zglinicki T., van Deursen J., Lustgarten J., Scrable H. Fat tissue, aging, and cellular senescence. Aging Cell. 2010;9:667–684.
  4. Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 2006;5(2):187–95. Epub 2006/04/22. 10.1111/j.1474-9726.2006.00199.x
  5. Toutfaire M, Bauwens E, Debacq-Chainiaux F. Biochem Pharmacol. The impact of cellular senescence in skin aging: A notion of mosaic and therapeutic strategies.
  6. Oct 15;142:1-12. doi: 10.1016/j.bcp.2017.04.011. Epub 2017 Apr 10.
  7. L. Urbanelli, S. Buratta, K. Sagini, B. Tancini, C. Emiliani, Extracellular vesicles as new players in cellular senescence, Int. J. Mol. Sci. 17 (9) (2016).
  8. L. Urbanelli, S. Buratta, K. Sagini, B. Tancini, C. Emiliani, Extracellular vesicles as new players in cellular senescence, Int. J. Mol. Sci. 17 (9) (2016).
  9. M. Toutfaire et al., The impact of cellular senescence in skin aging: A notion of mosaic and therapeutic strategies, Biochem. Pharmacol. (2017), http://dx.doi.org/10.1016/j.bcp.2017.04.011
  10. Campisi J. Aging, cellular senescence, and cancer. Annual review of physiology. 2013;75:685–705. Epub 2012/11/13. 10.1146/annurev-physiol-030212-183653 .
  11. Herbig U., Ferreira M., Condel L., Carey D., Sedivy J.M. Cellular senescence in aging primates. Science. 2006;311(5765):1257.
  12. Zhu Y, Armstrong JL, Tchkonia T, Kirkland JL. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr Opin Clin Nutr Metab Care. 2014;17:324–28. doi: 10.1097/MCO.0000000000000065.
  13. Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. Targeting senescent cells enhances adipogenesis and metabolic function in old age. eLife. 2015;4:e12997. doi: 10.7554/eLife.12997.
  14. Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO, Lowe V, Tchkonia T, Westendorf JJ, Kirkland JL. Transplanted senescent cells induce an osteoarthritis-like condition in mice. J Gerontol A Biol Sci Med Sci. doi: 10.1093/gerona/glw154.2016glw154
  15. Jeyapalan JC, Sedivy JM. Cellular senescence and organismal aging. Mech Aging Dev. 2008;129(7–8):467–74. Epub 2008/05/27. 10.1016/j.mad.2008.04.001
  16. Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging cell. 2015;14(4):644–58. 10.1111/acel.12344
  17. Wang Y, Chang J, Liu X, Zhang X, Zhang S, Zhang X, et al. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging (Albany NY). 2016;8(11):2915–26. 10.18632/aging.101100. PMC5191878.
  18. Zhu Y, Tchkonia T, Fuhrmann‐Stroissnigg H, Dai HM, Ling YY, Stout MB, et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors. Aging Cell. 2016;15(3):428–35. 10.1111/acel.12445
  19. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013;19:151–62. doi: 10.1089/ars.2012.4901.
  20. MJ Yousefzadeh, Zhu Y et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.
  21. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425(6954):191–196.
  22. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M. Sirtuin activators mimic caloric restriction and delay aging in metazoans. Nature. 2004;430(7000):686–689.
  23. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med. 2001;30:433–46. doi: 10.1016/S0891-5849(00)00498-6.
  24. Iannello A., Thompson T.W., Ardolino M., Lowe S.W., Raulet D.H. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J Exp Med. 2013;210(10):2057–2069
  25. Prasath G.S., Subramanian S.P. Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats. Food Chem Toxicol. 2013;59:249–255.
  26. Arai Y., Watanabe S., Kimira M., Shimoi K., Mochizuki R., Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr. 2000;130(9):2243–2250
  27. Zhu Y., Tchkonia T., Pirtskhalava T., Gower A., Ding H., Giorgadze N. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015;14:644–658.
  28. Niedernhofer L.J., Robbins P.D. Senotherapeutics for healthy aging. Nat Rev Drug Discov. 2018;17(5):377.
  29. Kirkland J.L., Tchkonia T., Zhu Y., Niedernhofer L.J., Robbins P.D. The clinical potential of senolytic drugs. J Am Geriatr Soc. 2017;65(10):2297–2301
  30. T. Tchkonia, Y. Zhu, J. van Deursen, J. Campisi, J.L. Kirkland, Cellular senescence and the senescent secretory phenotype: therapeutic opportunities, J. Clin. Invest. 123 (3) (2013) 966–972.
  31. Touil YS, Auzeil N, Boulinguez F, Saighi H, Regazzetti A, Scherman D, Chabot GG. Fisetin disposition and metabolism in mice: identification of geraldol as an active metabolite. Biochem Pharmacol. 2011;82:1731–39. doi: 10.1016/j.bcp.2011.07.097
CompositionSenolytic Complex
Daily dose: 3 capsules
Number of doses per pack: 30
Amount per dose
Quercefit® (Complex of phytosomes of sunflower and Sophora japonica quercetin standardised to 40% lecithin and 40% quercetin) 400 mg
Bromelain 2000 GDU/g 200 mg
Vitamin C (Ester C®) 100 mg*
Fisetin from Rhus succedanea stem 100 mg
Extract of decaffeinated black tea leaves 300 mg
Nicotinamide mononucleotide 10 mg
Other ingredients: acacia gum, white rice flour.
*125% of RDA for Vitamin C
Quercefit®, Indena, Italy. Ester C®, Ester C Company.
Directions for useSenolytic Complex
Adults. Take 3 vegetarian capsules a day.
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