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Welcome Shop by health concern Anti-ageing Senolytic Complex + AHCC
Senolytic Complex + AHCC
Senolytic Complex + AHCC
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167.00 €(196.58 US$) is available
AHCC 500 mg
AHCC is an extract of shiitake mushroom root (Lentinus edodes).
  • Immune-stimulant and anti-tumour properties.
  • Stimulates the activity of various groups of white cells including NK (natural killer) cells.
  • Used for many years in traditional Asian medicine.
Senolytic Complex
Senolytic Complex is a revolutionary formula for destroying the senescent cells responsible for ageing.
  • Has a rapid and long-lasting rejuvenating effect on the whole body.
  • Encourages self-destruction of the senescent cells responsible for ageing and age-related health issues (muscle weakness, cognitive decline, cardiovascular problems, chronic inflammation…).
  • Rich in fisetin, the most powerful natural senolytic compound identified.
  • Contains quercetin phytosome, 20 times more absorbable than standard quercetin.
  • Draws on the very latest scientific research (senotherapy).
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Plate of shiitake mushrooms

This dietary supplement has been formulated to offer the benefits of AHCC (Active Hexose Correlated Compound), a rare compound developed by Japanese scientists. It is obtained by fermenting an extract of a mushroom popular in Asia and Europe called shiitake (Lentinus edodes). Interest in the health benefits of this mushroom is far from recent however – it has been used for many years in traditional Asian medicine. The result of considerable research, AHCC offers the benefits of a combination of different active principles with immune-stimulant and anti-tumour properties.

What are the benefits of AHCC?

Since it was developed and its therapeutic virtues revealed, AHCC has been used by many thousands of people, its use supported by studies conducted in over 30 university research institutes and 700 hospitals in Japan and across the world.

  • Among the active principles in AHCC are the derivatives alpha-glucan and beta-glucan, polysaccharides recognised for their immune-stimulant effects. They boost the immune system by stimulating the activity of various groups of white cells including NK (natural killer) cells, recognised as the body's first line of defence against attack.
  • The active principles in AHCC also increase concentrations of T and B lymphocytes, white blood cells which act in a specific way against pathogens. These immune-stimulant effects therefore make this fermented shiitake extract a valuable aid in the prevention of various diseases.
  • The immune-stimulant properties of AHCC, demonstrated in in vitro and clinical studies, have rapidly attracted the interest of the scientific community for their potential to fight certain cancers. There is a particular focus on AHCC's stimulant effect on NK cells as they are such a vital line of defence against cancer cells.
  • Part of the immediate innate immune response, NK lymphocytes are able to recognise and destroy tumour cells within a few hours. Suffice to say that AHCC's stimulation of these ‘killer cells' paves the way for promising new therapeutic perspectives in the fight against cancer!

In order to offer a high-quality immune-stimulant supplement, shiitake extracts standardised to 60% AHCC are obtained in a laboratory in accordance with GMP and ISO 9100 & 22000 standards, and delivered in capsules containing an optimal 500mg, with a suggested dose of one to two capsules a day. This dose can be adapted to individual needs and the advice of your therapist. For optimal efficacy, AHCC's beneficial effects can be complemented by other natural active principles such as lactoferrin, a powerful antioxidant with immune-stimulant properties. The formulation Resveratrol Synergy is also a valuable aid with its exceptional antioxidant content, while the patented product AC-11 can help prevent mutations to DNA.

CompositionAHCC 500 mg
Daily dose: 2 Caspusles
Number of doses per pack: 30

per dose

Shiitake mushroom (Lentinus edodes) root extract (containing AHCC). 1 000 mg
Other ingredients :Acacia gum.
Directions for useAHCC 500 mg
Take one to two capsules a day, or as recommended by your health practitioner.
Senescent cell under a target mark

Senolytic Complex is a completely new ‘senolytic’ formulation for fighting the ageing process, based on the very latest discoveries in anti-ageing medicine, now available to buy at Supersmart. The term ‘senolytic’, recently coined by the scientific community, describes the ability to eliminate senescent cells (ie, aged cells), the presence of which has been identified in recent years as being, along with oxidative stress and telomere shortening, one of the causes of ageing. Since there was previously no way of preventing or slowing down this process, Senolytic Complex constitutes a truly revolutionary treatment.

The formulation contains the most powerful, natural, senolytic compounds identified to date: quercetin (in a form 20 times more bioavailable than standard quercetin), theaflavin, and most importantly, fisetin, an extraordinary flavonoid that’s really setting the scientific community alight.

Who is Senolytic Complex aimed at?

Senolytic Complex is for anyone over 40, whether as a course of treatment, or as long-term supplementation, to eliminate senescent cells and prevent their reappearance.

It is particularly recommended for the following groups of people:

  • Those who wish to extend their life expectancy.
  • Those keen to maintain good physical condition and optimal health as they age.
  • Those who are already suffering from age-related problems (muscle weakness, cardiovascular disorders, vision and hearing impairment, cognitive decline, osteoporosis …) and those who wish to reduce their risk of developing them.

How does Senolytic Complex work?

The discovery of senescent cells invading the body

In 2014, researchers achieved a major advance in the fight against ageing. They identified old, worn-out cells in the tissues of subjects aged over 40. Termed ‘senescent’, these zombie-like cells (1) are deformed and unable to divide, and are distributed throughout the body’s tissues. Though no longer functioning normally, they are not eliminated and thus accumulate pathologically.

These cells are rare in young people but increase with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, kidneys and skin (2-3).

Their dramatic effects on healthy cells and on the body

Unfortunately, senescent cells do not just take over, they also impede the activity of neighbouring healthy cells by continually releasing pro-inflammatory cytokines (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) into the extracellular environment (4-7). These substances are really distress calls: they signal to other cells the advanced state of deterioration in which they find themselves, but at the same time, they significantly affect the function of neighbouring healthy cells (8)!

Over the last three years, a number of studies have shown that the level of senescent cells in the body is directly linked to the pace of ageing (9) and the development of age-related health problems. Even a small amount of these cells is enough to wreak havoc in tissues(10) and induce the onset of many age-related problems: systemic inflammation, arthritis, atherosclerosis, chronic diseases (11), sarcopenia, cataracts, insulin resistance, vascular hypo-reactivity (12) (13) ...

How can we get rid of these ‘parasitic’ cells?

These cells normally destroy themselves in a process called apoptosis, in order to avoid damaging the body. However, this mechanism does not always work in which case the senescent cells continue to parasitize the body and cause chaos all around them (14).

Fortunately, researchers have identified several compounds that are specifically capable of repairing this defective mechanism and bringing about the self-destruction of these senescent cells. These extraordinary compounds are called ‘senolytics’.

The first study to identify senolytics was published in 2015 in the well-known scientific journal Aging Cell (15). Quercetin, a natural flavonol compound, combined with an anti-cancer drug, was found to dramatically decrease both the number of senescent cells and secretion of pro-inflammatory factors in the organism studied. In just five weeks, this combination resulted in a significant reduction in mortality and physical deterioration.

Dozens of studies have since identified natural compounds with the same properties (16-17). This has led to the development of a revolutionary new therapy, senolytic treatment, which is able to selectively destroy senescent cells and thus reduce the severity of age-related diseases, increase resilience and longevity, and delay the effects of ageing.

The treatment is essentially a massive ‘spring clean’, after which healthy cells regain control of the body and again function at full capacity. It represents a significant advance in the fight against ageing.

What is in Senolytic Complex capsules?

Senolytic Complex contains three exceptional senolytic compounds (fisetin, quercetin and theaflavin) and three other anti-ageing compounds of interest (vitamin C, nicotinamide mononucleotide and bromelain).

How does Senolytic Complex work?

How does Senolytic Complex work?

Fisetin, the most powerful senolytic.

Fisetin is part of the large family of flavonoids, a group of polyphenol antioxidants (18) found in small amounts in strawberries, mangos and certain plants. Of all the flavonoids tested, it was shown to be the most effective at reducing senescent cells (19).

It helps extend longevity (20-21) and reduce markers of senescence in humans. Its hydrophobic nature means it penetrates cells easily via cell membranes (22) and subsequently promotes the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins. One of its specific abilities is to reduce the fraction of senescent cells in the immune system (T lymphocytes and NK cells), thus increasing its beneficial effect, since immune cells are important for clearing out senescent cells (23). In addition, it inhibits the activity of several inflammatory cytokines such as TNFα, IL-6, and the transcription factor NF-Κb, and also offers anti-hyperlipidaemia effects (24).

It is supplied at a dose of 100mg a day (an average 0.4mg a day is consumed from the diet (25)).

For more information on fisetin and its senolytic properties, see: Fisetin is a senotherapeutic that extends health and lifespan.

Quercetin and theaflavin, two other major senolytic compounds

Since senescent cells use different mechanisms to resist programmed cell death (26-27), it’s important that other senolytic compounds are included in the formulation. Quercetin and theaflavin have been selected as two natural senolytics highlighted in the research.

Like fisetin, quercetin is also a member of the flavonoid family. It is extracted from Styphnolobium japonicum, the ‘Japanese pagoda tree’ or ‘honey tree’, and is delivered in a phytosome form which maximises its absorption into the bloodstream. It is recognised as being a benchmark senolytic, in combination with theaflavin, a polyphenol from black tea.

Bromelain, NMN and vitamin C

Senolytic Complex is enhanced by the addition of anti-ageing substances that work in symbiosis, such as nicotinamide mononucleotide, an element essential for cellular energy production and longevity of sirtuin proteins, bromelain, an enzyme which actively opposes systemic inflammation, and vitamin C (in its non-acid form), a potent antioxidant that supports the immune system.

How should Senolytic Complex be taken?

Senolytic Complex can either be used as an annual or quarterly treatment (28), or taken continuously, according to your needs. The capsules should be taken at mealtimes.

Senolytic treatment (senotherapy) can be undertaken as a three-step programme:

  1. Eliminate senescent cells from your body (even a partial cleansing appears to bring benefits (29)) with the aid of Senolytic Complex.
  2. Prevent the development of new senescent cells by improving your lifestyle, protecting yourself against the factors that cause cellular ageing, and strengthening both your DNA repair systems (with the aid of DNA Repair) and antioxidant systems (with the aid of Resveratrol synergy). With its vitamin C and bromelain, Senolytic Complex plays an active role in preventing the reappearance of senescent cells. A number of mechanisms are responsible for their development but two appear to be dominant: high inflammation levels and oxidative stress.
  3. Stimulate and boost the immune system so that it too can help clear out senescent cells (with the aid of an immunostimulant mushroom extract).

Attention: fisetin should not be taken in conjunction with antivitamin K drugs, which are commonly used oral anticoagulants (30).

The very latest research shows that a formulation such as this can produce powerful rejuvenating effects, improve the condition of those affected by age-related health problems, slow down the ageing process and extend lifespan. Exceptional benefits which place this dietary supplement right at the top of anti-ageing nutrition and which should come as welcome news for many people…

Written: April 2019

Note: this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.

Buy Senolytic Complex to fight the ageing process.

CompositionSenolytic Complex
Daily dose: 3 capsules
Number of doses per pack: 30
Amount per dose
Quercefit® (Complex of phytosomes of sunflower and Sophora japonica quercetin standardised to 40% lecithin and 40% quercetin) 400 mg
Bromelain 2000 GDU/g 200 mg
Vitamin C (Ester C®) 100 mg*
Fisetin from Rhus succedanea stem 100 mg
Extract of decaffeinated black tea leaves 300 mg
Nicotinamide mononucleotide 10 mg
Other ingredients: acacia gum, white rice flour.
*125% of RDA for Vitamin C
Quercefit®, Indena, Italy. Ester C®, Ester C Company.
Directions for useSenolytic Complex
Adults. Take 3 vegetarian capsules a day.

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Senolytic Complex + AHCC
167.00 €
(196.58 US$)
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