Yes, but they are minor:
• You should not exceed 1 gram of oral supplementation per 24 hour period.
• Applying undiluted oil to the skin may cause slight irritation.
• If you’re on medication for high blood pressure, consult your doctor before taking this oil.
• It may cause dermatitis or swollen eyelids in highly allergic individuals.
• You should ideally choose gastro-resistant capsules (softgels) as rancidity of the oil may cause stomach problems.
• These minor side-effects are rare and should not deter you from taking this natural, easy-to-take, multi-beneficial supplement.

Xanthohumol’s mechanisms of action come from its extraordinarily high content of phenolic compounds. Recent studies show that regular consumption of these compounds can, in the long term, reduce the risk of many chronic health disorders such as cardiovascular disease (19). Phenols, and in particular, xanthohumol, exert modulatory effects in cells by interacting with a wide range of molecular targets of signalling pathways (mitogen-activated protein kinase, protein kinase C, detoxifying antioxidant enzymes …) (20). These effects translate into increased expression of certain cytoprotective genes, regulation of the normal cell cycle, inhibition of growth, an increase in apoptosis, inhibition of angiogenesis, as well as suppression of oxidative stress, a state of imbalance which impairs the structural and functional integrity of cell membranes (21). The role played by oxidative stress in the development of chronic diseases is now widely documented in the scientific literature (22). Phenolic compounds can also influence the composition of gut microbiota and re-establish intestinal barrier function, thus modulating the chronic inflammation associated with metabolic diseases (23). Following ingestion, phenolic compounds such as xanthohumol are absorbed, distributed to various tissues and then metabolised by the liver. A proportion undergo partial conversion by gut flora. (24).

Xanthohumol’s mechanisms of action come from its extraordinarily high content of phenolic compounds. Recent studies show that regular consumption of these compounds can, in the long term, reduce the risk of many chronic health disorders such as cardiovascular disease (19). Phenols, and in particular, xanthohumol, exert modulatory effects in cells by interacting with a wide range of molecular targets of signalling pathways (mitogen-activated protein kinase, protein kinase C, detoxifying antioxidant enzymes …) (20). These effects translate into increased expression of certain cytoprotective genes, regulation of the normal cell cycle, inhibition of growth, an increase in apoptosis, inhibition of angiogenesis, as well as suppression of oxidative stress, a state of imbalance which impairs the structural and functional integrity of cell membranes (21). The role played by oxidative stress in the development of chronic diseases is now widely documented in the scientific literature (22). Phenolic compounds can also influence the composition of gut microbiota and re-establish intestinal barrier function, thus modulating the chronic inflammation associated with metabolic diseases (23).

Following ingestion, phenolic compounds such as xanthohumol are absorbed, distributed to various tissues and then metabolised by the liver. A proportion undergo partial conversion by gut flora. (24).

The recommended dose is two capsules a day, to be taken with meals.

If you want to boost its effects on sleep, it’s worth knowing that hops acts synergistically with other supplements available to buy at Supersmart such as valerian (found in the natural formulation Advanced Sleep Formula). For improving hormone balance, it’s better to combine it with an extract of pumpkin seeds.

Buy Xanthohumol capsules to support cellular health.

This product’s softgels are of bovine origin. They are particularly suitable for supplements that require rapid solubility. Made from high-quality bovine gelatine, they are safe and effective.

This product’s capsules are composed of HPMC (hydroxypropyl methylcellulose), a plant substance derived from cellulose. HPMC is widely used for medicines and dietary supplements. It contains no animal ingredients, is recognised as safe by health authorities and is considered more sustainable than synthetic alternatives.