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Alpha Lipoic Acid 250mg is a dietary supplement containing alpha-lipoic acid, a sulphur-containing antioxidant present in all prokaryotic (unicellular) and eukaryotic (multicellular) organisms. The human body is able to synthesise it from fatty acids and cysteine, but only in very small amounts (1).
Alpha Lipoic Acid 250mg contains the R form, the one produced naturally, and the S form, presumed inactive, in equal amounts. Two other supplements in our catalogue contain the natural form only: R-Lipoic Acid 100mg and Sodium R-Lipoate 300mg, a version with enhanced bioavailability.
What are alpha-lipoic acid’s properties?
Alpha-lipoic acid plays a role in regulating genes associated with antioxidant and inflammation pathways (2). As an enzymatic co-factor, it plays a key role in energy metabolism (3) and maximises the potency of vitamins C and E.
It exists in 2 forms: the R form (produced naturally by the body) and the S form (which appears to be inactive in the body). In the process of manufacturing alpha-lipoic acid, both forms are produced in equal amounts.
Supplements which contain the R form only are therefore more expensive to produce as they require the additional and costly step of eliminating all the S form molecules.
Are there any foods rich in alpha-lipoic acid?
There are very few good dietary sources: offal (particularly liver), a few green vegetables such as broccoli and spinach, and yeast.
It’s thought 200mg-600mg of alpha-lipoic acid in supplements (1 to 2 capsules of Alpha Lipoic Acid) provides 1000 times more alpha-lipoic acid than can be obtained from the diet (4).
What is in Alpha Lipoic Acid
Any questions?
It’s important to take it in between, rather than with, meals as its bioavailability is significantly reduced by other nutrients and micronutrients. Once ingested, it reaches the intestinal barrier where it monopolises two main transporters to enable it to reach various tissues (5). It is therefore broken down very quickly with a half-life of around 30 minutes (6).
Alpha-lipoic acid is highly-sensitive to heat, light and humidity: it’s therefore essential to store it in a cool, dry place away from light.
Clinical trials have shown no side-effects from daily doses of up to 2400mg a day, taken over extended periods (7).
Other ‘innovative’ antioxidant supplements which can be taken alongside alpha-lipoic acid include:
- FPP, a fermented papaya extract;
- N-Acetyl Cysteine 600mg, a glutathione precursor;
- SOD-Gliadins Complex, a superoxide dismutase (SOD) supplement.
This product’s capsules are composed of HPMC (hydroxypropyl methylcellulose), a plant substance derived from cellulose. HPMC is widely used for medicines and dietary supplements. It contains no animal ingredients, is recognised as safe by health authorities and is considered more sustainable than synthetic alternatives.
june 19 2023
This product does not do much even in a higher doses then recommended.
june 15 2025
Efficacité et bonne tolérance
Effectiveness and good tolerance
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may 28 2025
Absolument ravie je n’ai plus de douleurs neuropathiques aux jambes ni aux bras et ce rapidement
Absolutely delighted, I no longer have neuropathic pain in my legs or arms, and this happened quickly.
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february 11 2025
Le médecin a prescrit ce produit.
The doctor prescribed this product.
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january 5 2025
En prenant régulièrement ce produit, ma polyneuropathie ne le dérange plus ♥️.
By taking this product regularly, my polyneuropathy no longer bothers me ♥️.
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