Cannabidiol (CBD) is a phytocannabinoid molecule found in hemp ((Cannabis sativa) alongside the well-known psychotropic substance tetrahydrocannabinol (THC). However, unlike THC, CBD does not have any narcotic properties.

It is a natural compound which mimics the action of endocannabinoid messengers produced by the body. Like them, it is able to bind to specific receptors (CB1 and CB2) located on external cell membranes, and trigger various cellular responses such as restricting synaptic transmission, relieving pain and reducing spontaneous locomotion (1). Just like endogenous cannabinoids, CBD thus inhibits the transmission of small-diameter nociceptive fibres (which are involved in the pain process) and reduces the release of neurotransmitters like substance P, responsible for transmitting pain.

Unlike THC, which has a strong affinity for CB1 receptors, CBD binds more to CB2 receptors. These are found on the surface of cells of the central nervous system and in particular in immune system tissues where they are involved in modulating memory, emotions and pain (chronic, inflammatory or neuropathic) (2-3).

The CBD in this formulation is extracted from the leaves of the Cannabis sativa plant, using SC CO2 extraction. This is an alternative method to the potentially eco-harmful organochlorine solvents normally used in extraction processes. It’s a very environmentally friendly approach which ensures there are no solvent residues in the end product and helps preserve the chemical integrity of the heat-sensitive molecules.

This depends on several factors:

• The concentration of the CBD.
• A person’s weight.
• Individual biological factors.
• The severity of the initial problem or symptoms.

For someone with a bodyweight of 70kg, and where the product is standardised to 17% CBD, the optimal dose would be 25mg, although this can be gradually increased to 50mg depending on the results obtained (though this higher dose should not be exceeded). CBD can also be vaporised but the most stable and consistent mode of administration is expertly-dosed, oral capsules.

“Over a lifetime, our body’s physiology changes, as does the number and distribution of receptors in the endocannabinoid system which are directly responsible for interactions with CBD. The optimal dose will therefore change depending on the individual and age“Nick Jikomes, PhD, neuro-physician.

• It’s a highly promising natural alternative for controlling the kind of pain for which conventional medicine remains largely ineffective.
• It contains an unequalled level of CBD: the hemp extract used is standardised to 88%. Yet again, Supersmart has prioritised excellence.
• It’s packaged discreetly and elegantly allowing you to take it anywhere and use it as required.
• It’s 100% natural, containing no parabens, artificial colourings, toxins, heavy metals, chemical additives, hormone disruptors or other synthetic compounds often found in pain relief creams.
• It has an attractive woody, terpene aroma, and feels pleasant on the skin.

Note: unlike the narcotic drug of the same name, the cannabis used here does not contain THC It thus has no psychotropic effect on the user and has an excellent safety record in humans.

Buy CBD Balm to help relieve pain.

Unlike the drug cannabis which usually contains around 15% THC, the form used in this product has none. It therefore has no psychotropic effects and has an excellent safety profile in humans.

Once ingested, CBD is rapidly distributed around the body. It is lipophilic and thus quickly crosses the blood-brain barrier to reach brain tissues. It has no effect on heart rate, blood pressure or body temperature. CBD’s half-life is around 9 hours after which it is excreted in a metabolised form in urine.

To date, no public health problem has been associated with the nutritional use of CBD.

This product’s capsules are composed of HPMC (hydroxypropyl methylcellulose), a plant substance derived from cellulose. HPMC is widely used for medicines and dietary supplements. It contains no animal ingredients, is recognised as safe by health authorities and is considered more sustainable than synthetic alternatives.