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St John's Wort Extract Supplement
St John's Wort Extract Supplement
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St John's Wort Extract
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22.00 €(23.83 US$) in stock
Description

High-quality St John’s Wort supplement for supporting mental health

  • Helps to maintain positive mood and psychological stability.
  • Helps to reinvigorate the body.
  • Approved by the WHO, Commission E and ESCOP.
  • In capsule form, and standardised in hypericin for enhanced efficacy.
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St John's Wort yellow flower

St John's Wort Extract 60 Caps: Food Supplement with 0,3% of Hypericin

St John's Wort Extract is a supplement containing St John’s Wort, aimed at treating mood disorders (1). It’s a natural anti-depressant approved by the WHO for combatting inner restlessness and anxiety, and which helps to alleviate sleep problems. Its content of hypericin, the plant’s main active principle, has been standardised to enhance its efficacy.

What exactly is St John’s Wort?

St John’s Wort is a plant rich in phenolic compounds (caffeic and chlorogenic acids, tannin, rutin, hyperoside, quercetol (2)). However, its effects on mood are generally attributed to naphtodianthrones, particularly hypericin, a pigment responsible for the colour of the oil released from the blackish dot-like glands on the plant’s flowers and leaves.

How does St John’s Wort affect mood?

St John’s Wort’s mechanism of action is not yet fully understood. We know that its bioactive constituents include flavonoids, procyanidins, hyperforin and hypericin, and that it works via a different mechanism to that of normal anti-depressants.

The serotonergic, noradrenergic and dopaminergic systems and gamma-aminobutyric acid (GABA) pathways, may all be involved in the action of St John’s Wort. It has been shown in studies to inhibit synaptic reuptake of serotonin, dopamine and noradrenaline (3), as well as to have a significant affinity for adenosine, GABA and glutamate receptors. There seems to be a synergistic effect between hyperforin, hypericin (4) and various flavonoids (5) in the reuptake of neurotransmitters and adrenergic and serotonergic receptor density (6).

St John’s Wort may also be involved in regulating genes that control the function of the hypothalamic-pituitary axis.

What are the effects of St John’s Wort? And how much should you take?

Researchers have shown St John’s Wort to be as effective at ‘chasing away the blues’ naturally as anti-depressants (7-8) in a meta-analysis of 29 clinical trials (involving close to 6000 subjects) (9). Participants in these trials received between 500mg and 1200mg of St John’s Wort containing 0.2% hypericin, for between 4 and 8 weeks (10) (that’s 2-3 capsules of St John's Wort Extract).

The hypericin in St John’s Wort also has sedative properties (11). It may help to reduce the physical symptoms of withdrawal and induce vasodilatory effects.

Its use for reducing anxiety and depression (resulting from nervous fatigue, overwork, stress, etc.) is recognised by ESCOP, Commission E and the WHO.

How should St John's Wort Extract be taken?

St John’s Wort supplements are produced from the dried flowering tops. According to the author of one study, positive effects only start to be felt after 10-15 days’ use, like any antidepressant.

While St John’s Wort causes far fewer side-effects than antidepressant drugs, it’s important to be aware of certain contraindications. You should not suddenly replace an antidepressant drug with St John’s Wort as it can interact with the breakdown products of the drug. It’s therefore advisable to leave a gap between the two.

Anyone taking oral anticoagulants should avoid St John’s Wort because of its enzyme-inducing effect. The same applies to those on anticonvulsant drugs, progestogen contraceptives, immune-suppressants, and inhibitors of protease or tyrosine kinase. If you are in any doubt, it is best to consult a health professional before taking it.

People with very fair skin who want to benefit from St John’s Wort should avoid intense exposure to the sun’s ultraviolet rays because of the risk of phototoxicity.

Composition
Daily serving: 3 capsules
Number of servings per bottle: 20
Quantity per serving
St. John's Wort extract standardised to contain 0.3% of Hypericin 900 mg
Other ingredients: Acacia gum

Each capsule contains 300 mg of St. John's Wort extract standardized to contain 0,3% of Hypericin.
Directions for use
Take 3 capsules per day (1 with each meal): This dosage is the one used in the studies mentioned below. To obtain the best results, you must take St. John's Wort for at least 4 to 6 weeks.
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References
  1. Busser, C. et E., Les plantes des Vosges Médecine et traditions populaires. Strasbourg, La Nuée Bleue, 2005, 160-162.
  2. Bruneton J., Pharmacognosie, phytochimie, plantes médicinales. Paris, Editions Tec
  3. & Doc, 1999, 3e édition, 440-445.
  4. Butterweck V. Mechanism of action of St John’s wort in depression : what is known? Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Germany. CNS Drugs. 2003, 17, 539-562.
  5. Linde K, Berner M. and Kriston L. St John’s wort for major depression (Review). The Cochrane Library. 2009, 4, 1-103.
  6. Morel J-M. Phytothérapie et troubles psychiatriques : possibilités d’application avec le Millepertuis. La Phytothérapie Européenne. Novembre/Décembre 2005, 8-14.
  7. Wonnemann M., Singer A. and Müller W. Inhibition of Synatosomal Uptake of 3 H-Lglutamate and 3 H-GABA by Hyperforin, a Major Constituent of St. John’s Wort : The Role of Amiloride Sensitive Sodium Conductive Pathways. Neuropsychopharmacology. 2000, 23, 188-197
  8. Linde K., Ramirez G., Mulrow C., Pauls A., Weidenhammer W. and Melchart D. St John’s wort for depression-an overwiew and meta-analysis of randomised clinical trials. BMJ. 1996, 313, 253-258.
  9. Whiskey E., Werneke U. and Taylor D. A systematic review and meta-analysis of Hypericum perforatum in depression : a comprehensive clinical review Intern Clin Psychopharmacology. 2001, 16, 239-252.
  10. Linde K, Berner M. and Kriston L. St John’s wort for major depression (Review). The Cochrane Library. 2009, 4, 1-103.
  11. Szegedi A., Kohnen R., Dienel A. and Kieser M. Acute treatment of moderate to severe depression with hypericium extract WS 5570 (St John’s wort) : randomised controlled double blind non-inferiority trial versus paroxetine. BMJ. 2005, 330, 503- 507.
  12. Morel J-M. Phytothérapie et troubles psychiatriques : possibilités d’application avec le Millepertuis. La Phytothérapie Européenne. Novembre/Décembre 2005, 8-14.

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