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SAM-e 200 mg

SAM-e dietary supplement for depressed or anxious people

6 reviewsRead reviews

SAM-e (S-adenosyl-methionine) is a powerful and pluripotent nutrient obtained naturally by microbiological fermentation.
  • Key element of the energy production process.
  • Helps to counter depression naturally.
  • Has anti-ageing and anti-inflammatory properties.
  • Stimulates the detoxification and regeneration of the liver

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60 DR Caps™

67.00 €


60 DR Caps™

67.00 €

61.64 €

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SAM-e 200 mg

No controversial excipients
No sweeteners

SAM-e is a powerful and pluripotent nutrient which can be life-changing when taken at sufficient levels and in the right form, now available to buy at Supersmart. It is a naturally-occuring compound in the body which promotes methylation, the process whereby methyl groups (one atom of carbon and 3 of hydrogen) are transferred from one molecule to another. Methylation is essential for many enzymatic processes and SAM-e is the most active of all methyl donors.

What is SAM-e?

SAM-e is a chiral molecule which exists in two forms: an active isomer (S,S) and an inactive isomer (R, S). All SAM-e products contain these two isomers in varying percentages. The SAM-e that we offer contains 70-80% of the (S,S) form which is the highest level available in a pharmaceutical grade product. Some (too) cheap products contain just 47% or less. The SAM-e we offer is obtained naturally, by microbiological fermentation and without use of solvents. It is specially packaged to ensure optimal stability and biological activity.

What are the benefits associated with SAM-e capsules?

We introduced SAM-e into Europe in 1998 and while its price has now been reduced by over 70%, it remains an expensive nutrient. Indeed, SAM-e has been the subject of dozens of clinical studies involving thousands of patients.

  • SAM-e helps treat depression naturally, and without any side-effects. It simultaneously increases levels of several neurotransmitters - deficient in patients being treated for depression.
  • The methylation promoted by SAM-e is a key element of the energy production process, particularly the recycling of adenosine triphosphate (ATP).
  • SAM-e has a beneficial effect on the mechanisms of ageing by protecting desoxyribonucleic acid (DNA) from demethylation.
  • SAM-e may also prevent cerebral ageing: in a recent animal study, SAM-e doubled glutathione levels in the brain and increased levels of its enzymatic metabolites by 98%. It decreased a marker of radical activity by 46%, and in culture, reduced lipid peroxidation by 55%.
  • In 2002, an American government agency, the Agency for Healthcare Research and Quality (AHRQ) concluded that SAM-e was 80% more effective than a placebo at relieving osteo-arthritis pain, and as effective as non-steroidal anti-inflammatory (NSAIDs) at treating osteo-arthritis. NSAIDs are associated with serious side-effects while SAM-e has health benefits for the whole body.
  • It also plays a crucial role in conjunctive tissue synthesis, eases joint pain, promotes mobility and protects cartilage from damage.
  • SAM-e supports hepatic synthesis of glutathione, an essential antioxidant. It stimulates the detoxification and regeneration of the liver. It has been used for treating cirrhosis and for helping people to give up alcohol and drugs.

Buy SAM-e capsules to support emotional well-being.

What is in it SAM-e 200 mg

Elemental S-adenosyl-methionine
Amino acid derivative

Any questions?

What are other supplements that might interest you?

As well as supplementing with SAM-e, you may find these other nutritional supplements of interest too.

Discover the properties of a Peptidea®, a fish protein hydrolysate that plays a regulatory role in the nervous system. See also Lactoxira, the first psychobiotic formulation for fighting depression.


This product is rated 4.7 out of 5 stars
There are 6 reviews






Excellent 6 Reviews

march 9 2024

Funciona muy bien

Florence Barlier

february 12 2024

Très bien pour éviter la chimie

Vernier Frederic

february 17 2021


Lady Christiane Juliana Vilain

july 13 2019

Bon produit


april 15 2019

Mais vos produits sont très bien je continue à le prendre

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