Alcohol Detox is a dietary supplement combining the best active substances for reducing the adverse effects of excessive alcohol consumption. Containing plant extracts targeted at liver health, it also provides vitamins, the uptake of which can be impaired by metabolising ethanol. Its synergistic formulation also acts at a cellular level to support the processes of detoxification.
What is in Alcohol Detox, the perfect supplement for alcohol-fuelled evenings and that ‘morning after misery’?
The anti-hangover supplement Alcohol Detox brings together exceptional active principles to help the body recover following heavy alcohol consumption :
- vitamin C. This helps protect cells against the oxidative stress triggered by drinking alcohol. Some studies also point to a link between significant alcohol consumption (> 80g a day) and the development of scurvy (3) ;
- sodium R-lipoate. A sodium salt of alpha-lipoic acid, an important sulphur-containing compound, it appears to play a key role in recycling glutathione (4) ;
- thiamine. This water-soluble form of vitamin B1 helps maintain normal energy metabolism and nervous system function (5). It is combined here with benfotiamine, a fat-soluble derivative of thiamine, for enhanced efficacy (6) ;
- asparagine. A study conducted with control groups suggests a plausible link between decreased serum levels of asparagine, a proteinogenic amino acid, and subsequent diagnosis of an alcohol-related disease (7) ;
- extract of milk thistle (Silybum marianum), standardised to 80% silymarin. A plant originating from the Mediterranean region, milk thistle was much-prized by the Greeks for relieving liver problems. Helping to maintain normal liver function, it seems to exert a regenerating and protective effect on hepatocytes via its main active principle, silymarin (8) ;
- extract of kutki (Picrorhiza kurroa). A plant that grows at high altitudes on Himalayan mountainsides, it is similar to Indian gentian in Ayurvedic medicine. Its root promotes normal liver function, offering remarkable hepatoprotective activity (9) ;
- extract of kudzu (Pueraria lobata). The adaptogenic properties of this climbing vine are attracting scientific interest, with one study showing promising prospects in its examination of the plant’s effects on dependency in heavy drinkers (10).
Note: the supplement Alcohol Detox is not designed to reduce blood ethanol levels.
How is ethanol eliminated from the body?
With the chemical formula C2H5OH, ethanol (or ethyl alcohol) is the psychotropic molecule common to all alcoholic drinks. Partially captured by the stomach, its reabsorption takes place primarily in the gut. It then reaches the liver, via the portal vein, where it is degraded (up to 80%).
Alcohol metabolism involves three major enzymes: alcohol dehydrogenase (ADH), cytochrome P450 and catalase. These are responsible for converting ethanol into acetaldehyde, which is itself converted into acetate by a fourth enzyme, aldehyde dehydrogenase (ALDH). These mechanisms remain largely effective depending on age, weight, ethnicity and medication.
Daily dose : 1 capsule
Number of doses per box : 120 |
Amount per dose |
L-cysteine hydrochloride |
125 mg |
Ascorbic acid |
125 mg |
Sodium R-lipoate |
50 mg |
Thiamine HCl |
50 mg |
Asparagine |
50 mg |
Milk thistle 80 % silymarin |
50 mg |
Picrorhiza kurroa 4 % Kutkin |
50 mg |
Kudzu 40 % isoflavones |
50 mg |
Benfotiamine |
25 mg |
Other ingredients:Acacia gum, rice flour.
|
adults. Take one capsule with each glass of alcohol.
Attention : Alcohol Detox will not prevent you from getting drunk nor affect your blood alcohol levels. However, Alcohol Detox can significantly reduce alcohol’s harmful effects: hangover, malnutrition, oxidative stress, liver and brain toxicity.
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- Lim DJ, Sharma Y, Thompson CH. Vitamin C and alcohol: a call to action. BMJ Nutr Prev Health. 2018;1(1):17-22. Published 2018 Dec 5. doi:10.1136/bmjnph-2018-000010
- Pirlich M, Kiok K, Sandig G, Lochs H, Grune T. Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells. Neurosci Lett. 2002 Aug 9;328(2):93-6. doi: 10.1016/s0304-3940(02)00415-9. PMID: 12133563.
- Langlais PJ. Alcohol-Related Thiamine Deficiency: Impact on Cognitive and Memory Functioning. Alcohol Health Res World. 1995;19(2):113-121.
- Manzardo AM, He J, Poje A, Penick EC, Campbell J, Butler MG. Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. Drug Alcohol Depend. 2013;133(2):562-570. doi:10.1016/j.drugalcdep.2013.07.035
- Kärkkäinen O, Klåvus A, Voutilainen A, Virtanen J, Lehtonen M, Auriola S, Kauhanen J, Rysä J. Changes in Circulating Metabolome Precede Alcohol-Related Diseases in Middle-Aged Men: A Prospective Population-Based Study With a 30-Year Follow-Up. Alcohol Clin Exp Res. 2020 Dec;44(12):2457-2467. doi: 10.1111/acer.14485. Epub 2020 Nov 2. PMID: 33067815.
- Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y
- Rastogi R, Saksena S, Garg NK, Kapoor NK, Agarwal DP, Dhawan BN. Picroliv protects against alcohol-induced chronic hepatotoxicity in rats. Planta Med. 1996 Jun;62(3):283-5. doi: 10.1055/s-2006-957882. PMID: 8693047.
- Penetar DM, Toto LH, Lee DY, Lukas SE. A single dose of kudzu extract reduces alcohol consumption in a binge drinking paradigm. Drug Alcohol Depend. 2015;153:194-200. doi:10.1016/j.drugalcdep.2015.05.025
- Swift R, Davidson D. Alcohol hangover: mechanisms and mediators. Alcohol Health Res World. 1998;22(1):54-60.
- Patel R, Mueller M. Alcoholic Liver Disease. [Updated 2022 Jan 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK546632/
- Lieber CS. Metabolic effects of acetaldehyde. Biochem Soc Trans. 1988 Jun;16(3):241-7. doi: 10.1042/bst0160241. PMID: 3181606.
- Nutt D, Hayes A, Fonville L, et al. Alcohol and the Brain. Nutrients. 2021;13(11):3938. Published 2021 Nov 4. doi:10.3390/nu13113938
- Hoyumpa AM. Mechanisms of vitamin deficiencies in alcoholism. Alcohol Clin Exp Res. 1986 Dec;10(6):573-81. doi: 10.1111/j.1530-0277.1986.tb05147.x. PMID: 3544907.
- Madeira MD, Sousa N, Lieberman AR, Paula-Barbosa MM. Effects of chronic alcohol consumption and of dehydration on the supraoptic nucleus of adult male and female rats. Neuroscience. 1993 Oct;56(3):657-72. doi: 10.1016/0306-4522(93)90363-k. PMID: 8255426.
- Prescott LF. Paracetamol, alcohol and the liver. Br J Clin Pharmacol. 2000;49(4):291-301. doi:10.1046/j.1365-2125.2000.00167.x
- Mofredj A, Cadranel JF, Darchy B, Barbare JC, Cazier A, Pras V, Biour M. Toxicité hépatique du paracétamol à dose thérapeutique chez le sujet éthylique chronique. A propos de 2 cas d'hépatite mortelle chez des patients cirrhotiques [Hepatotoxicity caused by therapeutic doses of paracetamol in alcoholics. Report of 2 cases of fatal hepatitis in cirrhosis]. Ann Med Interne (Paris). 1999 Oct;150(6):507-11. French. PMID: 10615538.
- Shi, Peiying et al. “Honey reduces blood alcohol concentration but not affects the level of serum MDA and GSH-Px activity in intoxicated male mice models.” BMC complementary and alternative medicine vol. 15 225. 14 Jul. 2015, doi:10.1186/s12906-015-0766-5
- Shen Y, Lindemeyer AK, Gonzalez C, et al. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012;32(1):390-401. doi:10.1523/JNEUROSCI.4639-11.2012