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Welcome Shop by health concern Digestion & Oral health Bioperine®
Bioperine Supplement
Bioperine Supplement
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Bioperine®
Digestion & Oral health
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22.00 €(23.91 US$) Limited quantity
Description
Extract of black pepper (Piper nigrum) to maximise absorption of nutrients from food
  • Increases bioavailability of a number of micronutrients (2000% for curcumin)
  • Increases activity of digestive enzymes
  • Standardised to 95% natural piperine (the maximum available)
  • Increases thermogenesis
  • Stimulates the taste buds
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134.00
Green black pepper grains

Bioperine® 90 Caps: Black Pepper Dietary Supplement - Dosage, Reviews

Bioperine® is a black pepper extract (Piper nigrum) in vegetarian capsules, standardised to 95% piperine, to support digestive health.

What is piperine?

We’re all familiar with the hotness of black pepper: it is due to the biological activity of several active compounds, in particular piperine. Piperine is an alkaloid used for more than 20 years to maximise the bioavailability of nutrients.

Black pepper is one of three essential natural ingredients used in the majority of Ayurvedic formulations. It can increase absorption of selenium and vitamin C by up to 42% and 50% respectively. Below are just some of the many micronutrients where absorption can be improved by piperine:

  • Curcumin (1);
  • Iron (2);
  • Resveratrol (3);
  • Selenium;
  • Vitamin B6;
  • β-Carotene;
  • Extract of Boswellia serrata;
  • Extract of Ginkgo biloba, and
  • Proteins in general.

What are Bioperine® mechanisms of action?

Bioperine® effects are due to three distinct mechanisms of action:

  • Piperine helps increase intestinal activity of glycoprotein-P which is involved in the transport of many substances (including certain drugs) (4).
  • Piperine modifies the rate of glucurono-conjugation by reducing glucoronic acid content and inhibiting transferase activity (5). This mechanism enables foreign molecules to be solubilised for more effective elimination via urine.
  • Piperine also increases thermogenesis via the release of thermogenic hormones called catecholamines. This results in improved absorption of nutrients in the gut.

What are the benefits associated with Bioperine®?

In addition to optimising bioavailability, piperine also offers digestive benefits: it stimulates appetite and facilitates digestion (by increasing the activity of salivary amylase and trypsin, an enzyme in pancreatic juice which helps ‘break’ proteins (7)).

Note:

Piperine also helps increase the bioavailability of certain drugs such as ibuprofen (8). It therefore should not be taken at the same time as medication.

How is Bioperine® produced?

Black pepper is a climbing vine that grows in forest habitats and equatorial climates: it can only be cultivated between the latitudes 15 degrees north and 15 degrees south.

Black pepper is picked when the berries (or drupes) start to turn red: it is at this stage that the amount of essential oil is at its peak. They are then deseeded, dried in the sun till the berries go black, then plunged into boiling water for several minutes. The heat ruptures the peppers’ cell walls and releases heat-resistant enzymes. The drupes are then dried in the open air before the outer coating is removed.

In the case of Bioperine®, the piperine content is then increased so that it makes up around 95% of the natural black pepper extract.

It’s worth noting that while piperine can be synthesised in the laboratory using an enzyme called piperotransferase, Bioperine® contains natural piperine extracts from black pepper drupes, unlike many piperine supplements on the market.

Buy Bioperine® capsules to aid digestion.

Can Bioperine® be combined with other supplements?

Piperine potentiates the bioavailability of many supplements, but it is curcumin supplements known for their powerful anti-inflammatory effects, that most benefit from being combined with Bioperine®. Supersmart has curcumin supplements available to buy such as Curcumin Solution, Natural Curcuma and Super Curcuma.

Curcumin’s bioavailability is actually very low because it is quickly metabolised in the liver. Thus taking 2g of curcumin will only produce a very slight increase in plasma concentrations. However, taking piperine at the same time produces a clear increase in curcumin levels, in the region of 2000%, within around 30 minutes of ingestion (6).

The mechanism responsible is inhibition of glucurono-conjugation: this slows down the breakdown of curcumin by the liver, considerably expanding its window of absorption.

Composition
Daily serving: 3 capsules
Number of servings per bottle: 30
Quantity per serving
Black pepper extract (Piper nigrum) standardised to 95% piperin 30 mg
Other ingredients: Acacia gum, rice bran.
Bioperine® - Sabinsa Corporation.

Each vegetarian capsule contains 10 mg of Bioperine®.
Directions for use
Take one vegetarian Bioperine® capsule at the same time as your other supplements.
4.5
4.4 /5 5 reviews
Description
5
5.0 / 5
Quality
5
4.5 / 5
Value for money
5
4.8 / 5

Reviews 5
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BENCE Yves
5
Excellent
Mark
5
T. Bien - bon produit - utilisé avec chrysine
Bonnie74
4
Sur le long terme, le produit perd un peu de son efficacité. Peut-être faut-il faire un break et cesser de le prendre pendant une semaine pour retrouver un efficacité 100 %.

Dans l'ensemble, très bon produit avec un excellent rapport qualité prix.


EZIO Cervelli
3
molto buono
MORALES RENEO Lorenzo
5
Lo mejor para la absorción de los complementos
References
  1. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.
  2. Majeed M, Vaidyanathan P et al. An Evaluation of Bioavailability Enhancement of Organic Elemental Iron with BioPerine® in Rabbits, Human Journals March 2016 Vol.:5, Issue:4
  3. Johnson J, Nihal M et al. Enhancing the bioavailability of resveratrol by combining it with piperine, Mol Nutr Food Res. 2011 August ; 55(8): 1169–1176. doi:10.1002/mnfr.201100117.
  4. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002 Aug;302(2):645-50.
  5. Singh J, Dubey RK, Atal CK. Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content. J Pharmacol Exp Ther. 1986 Feb;236(2):488-93.
  6. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.
  7. Pruthi, J.S. (1980). Adv. Food Res., 4: 18-25
  8. Venkatesh S, Durga KD, Padmavathi Y, et al. (2011) Influence of piperine on ibuprofen induced antinociception and its pharmacokinetics. Arzneimittelforschung 61(9): 506–9

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