An exhaustive research review identified no toxicity or carcinogenicity, while studies on development and reproduction showed no adverse effect. Quercetin may, however, alter the bioavailability of cyclosporine, an immune suppressant used to prevent rejection of donor organs, so is best avoided in such cases.

The effects of quercetin can be enhanced by combining it with other antioxidant such as vitamin C or other anti-inflammatories like bromelain.

Fisetin 500 mg can either be used as a once a year, in a three-monthly treatment, or taken continuously, according to your needs. Tablets should be taken at mealtimes. Based on an animal study which produced extraordinary results, the dose selected was determined using the usual principle of dose conversion from animal to human (23).

It should be noted that curcumin inhibits the glucuronoconjugation of fisetin and thus its bioavailability (by a factor of 30 according to some studies). DHA, however, acts in synergy with fisetin to reduce bone resorption. Bioflavonoids such as pycnogenol and quercetin are mutually reinforcing and it is therefore equally appropriate to combine them.

Attention: fisetin should not be taken alongside vitamin K antagonists, a widely prescribed class of anticoagulant drugs (24).

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