Often recommended individually, PQQ and CoQ10 are combined in this supplement to take advantage of their synergistic effects. Indeed, recent research has shown that combining them in this way may strengthen their protective role against oxidative stress. These studies suggest that their antioxidant effects may be particularly enhanced in the cardiovascular and nervous systems. As a result, PQQ and CoQ10 are today associated with protecting the heart, red blood cells and brain, as well as preventing age-related problems such as memory loss and concentration deficit.

The suggested dose for this PQQ & CoQ10 supplement is two capsules a day. Other powerful antioxidants are also available at Supersmart for fighting age-related cellular damage such as resveratrol, the natural antioxidant found in grapes and red wine. For optimal efficacy, this protective compound can also be combined with other antioxidants such as in the synergistic formulation Resveratrol Synergy.

• An experiment on NMN in mice conducted by Professor David Sinclair of Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat ageing and its associated diseases.
• When Professor Sinclair and his colleagues injected this rare substance into two-year-old mice, they observed, after just one week's treatment, notable improvements to muscle (a reduction in muscle atrophy), enhanced insulin resistance and reduced inflammation, making the mice indistinguishable from younger animals.
• According to Dr Nigel Turner, a pharmacologist at the University of New South Wales, “It's like a 60-year-old being similar to a 20-year-old on some measures”. Professor Sinclair added: “If these results stand, then ageing may be a reversible condition, if it is caught early".
• In a report published in the journal Cell, the researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale - less than a week, in fact.
• The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN's ability to activate all seven of the SIRT genes involved in extending longevity.
• In humans as in mice, nicotinamide mononucleotide, at an average daily dose of 125mg - 1 capsule a day - could produce a natural reversal of the ageing process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.