If you’re looking for ways to slow down the rate at which your body is ageing, here are some key tips to help you stay younger for longer:

• take moderate exercise. To maintain healthy arteries and combat ageing of the heart, you should aim to engage in physical activity (walking, cycling, yoga, housework, gardening …) four or five times a week;
• keep yourself well-hydrated ! As we age, our skin tends to dehydrate. So to reduce the appearance of wrinkles as much as possible, drink a litre and a half of fluid a day (water, tea, herbal tea ...) and use a suitable moisturiser on your skin;
• preserve your memory. To maintain mental ability, you need to keep your brain active by engaging in activities such as crosswords, boardgames, reading, watching films, recalling celebrities’ names, using memory-boosting apps, etc. ;
• reduce pro-oxidant factors by limiting your consumption of barbecued food, charcuterie, fried food, fizzy drinks and alcohol, as well as avoiding smoking and exposure to UV rays … Excessive free radical release causes oxidative stress which accelerates cellular ageing;
• get enough sleep. A lack of sleep can lead to enlarged blood vessels in the brain, which causes a drop in cerebral blood pressure and thus an acceleration in cognitive decline. While we vary in the amount of sleep we need, aim for at least 7 hours a night to help slow down the ageing process.

Senolytic Complex contains three exceptional senolytic compounds (fisetin, quercetin and theaflavin) and three other anti-ageing compounds of interest (vitamin C, nicotinamide mononucleotide and bromelain).

Fisetin, the most powerful senolytic.

Fisetin is part of the large family of flavonoids, a group of polyphenol antioxidants (18) found in small amounts in strawberries, mangos and certain plants. Of all the flavonoids tested, it was shown to be the most effective at reducing senescent cells (19).

It helps extend longevity (20-21) and reduce markers of senescence in humans. Its hydrophobic nature means it penetrates cells easily via cell membranes (22) and subsequently promotes the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins. One of its specific abilities is to reduce the fraction of senescent cells in the immune system (T lymphocytes and NK cells), thus increasing its beneficial effect, since immune cells are important for clearing out senescent cells (23). In addition, it inhibits the activity of several inflammatory cytokines such as TNFα, IL-6, and the transcription factor NF-Κb, and also offers anti-hyperlipidaemia effects (24).

It is supplied at a dose of 100mg a day (an average 0.4mg a day is consumed from the diet (25)).

For more information on fisetin and its senolytic properties, see: Fisetin is a senotherapeutic that extends health and lifespan.

Quercetin and theaflavin, two other major senolytic compounds

Since senescent cells use different mechanisms to resist programmed cell death (26-27), it’s important that other senolytic compounds are included in the formulation. Quercetin and theaflavin have been selected as two natural senolytics highlighted in the research.

Like fisetin, quercetin is also a member of the flavonoid family. It is extracted from Styphnolobium japonicum, the ‘Japanese pagoda tree’ or ‘honey tree’, and is delivered in a phytosome form which maximises its absorption into the bloodstream. It is recognised as being a benchmark senolytic, in combination with theaflavin, a polyphenol from black tea.

Bromelain, NMN and vitamin C

Senolytic Complex is enhanced by the addition of anti-ageing substances that work in symbiosis, such as nicotinamide mononucleotide, an element essential for cellular energy production and longevity of sirtuin proteins, bromelain, an enzyme which actively opposes systemic inflammation, and vitamin C (in its non-acid form), a potent antioxidant that supports the immune system.

Alongside a course of spermidine, we recommend taking our famous supplement Senolytic Complex, formulated to eliminate senescent cells, one of the key cause of ageing. This unique formulation contains fisetin, bromelain, quercetin, black tea ... it is, in short, an amazing supplement combining the best nutrients in this field.

You could also increase your intake of pyrroloquinoline quinone (PQQ), a very specific molecule that helps to regenerate mitochondria, the powerhouses of the body’s cells. We recommend taking Mitochondrial Formula, an anti-ageing supplement that contains two other highly effective compounds: lipoic acid and carnitine.

Senolytic Complex can either be used as an annual or quarterly treatment (28), or taken continuously, according to your needs. The capsules should be taken at mealtimes.

Senolytic treatment (senotherapy) can be undertaken as a three-step programme:

1. Eliminate senescent cells from your body (even a partial cleansing appears to bring benefits (29)) with the aid of Senolytic Complex.
2. Prevent the development of new senescent cells by improving your lifestyle, protecting yourself against the factors that cause cellular ageing, and strengthening both your DNA repair systems (with the aid of DNA Repair) and antioxidant systems (with the aid of Resveratrol synergy). With its vitamin C and bromelain, Senolytic Complex plays an active role in preventing the reappearance of senescent cells. A number of mechanisms are responsible for their development but two appear to be dominant: high inflammation levels and oxidative stress.
3. Stimulate and boost the immune system so that it too can help clear out senescent cells (with the aid of an immunostimulant mushroom extract).