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S-adenosyl-methionine (SAM-e) is a naturally-occuring compound in the body which promotes methylation, the process whereby methyl groups (one atom of carbon and 3 of hydrogen) are transferred from one molecule to another. Methylation is essential for many enzymatic processes and SAM-e is the most active of all methyl donors. Indeed, SAM-e has been the subject of dozens of clinical studies involving thousands of patients.
What are the benefits associated with SAM-e?
SAM-e plays a crucial role in conjunctive tissue synthesis; it eases joint pain, promotes mobility and protects cartilage from damage. In 2002, an American government agency, the Agency for Healthcare Research and Quality (AHRQ) concluded that SAM-e was 80% more effective than a placebo at relieving osteo-arthritis pain, and as effective as non-steroidal anti-inflammatories (NSAIDs) at treating osteo-arthritis. NSAIDs are associated with serious side-effects while SAM-e has health benefits for the whole body:
- SAM-e supports hepatic synthesis of glutathione, an essential antioxidant. It stimulates the detoxification and regeneration of the liver. It has been used for treating cirrhosis and for helping people to give up alcohol and drugs.
- SAM-e helps treat depression naturally, more effectively and faster than anti-depressants, and without any side-effects. It simultaneously increases levels of several neurotransmitters - deficient in patients being treated for depression.
- The methylation promoted by SAM-e is a key element of the energy production process, particularly the recycling of adenosine triphosphate (ATP). SAM-e has a beneficial effect on the mechanisms of ageing by protecting desoxyribonucleic acid (DNA) from demethylation.
- SAM-e may also prevent cerebral ageing: in a recent animal study, SAM-e doubled glutathione levels in the brain and increased levels of its enzymatic metabolites by 98%. It decreased a marker of radical activity by 46%, and in culture, reduced lipid peroxidation by 55%. It is a powerful and pluripotent nutrient which can be life-changing when taken at sufficient levels and in the right form.
Why is SAM-e 400 mg supplement a better option?
We introduced SAM-e into Europe in 1998 and while its price has now been reduced by over 70%, it remains an expensive nutrient. It should be recognized that:
- SAM-e is a chiral molecule which exists in two forms: an active isomer (S,S) and an inactive isomer (R, S). All SAM-e products contain these two isomers in varying percentages. The SAM-e that we offer contains 70-80% of the (S,S) form which is the highest level available in a pharmaceutical grade product. Some (too) cheap products contain just 47% or less.
- SAM-e is a highly-reactive and therefore very fragile molecule which degrades rapidly when subjected to heat, humidity or gastric acids. In fact, a poorly packaged SAM-e product will degrade in just a few hours, resulting in a total lack of biological activity. In order to preserve SAM-e from heat and humidity, it is essential that each tablet is double foil blister-packed. To protect it from gastric acids, it must be enteric-coated: pharmacokinetic studies show that this results in maximum serum levels. This type of packaging is more expensive but it is quite simply essential.
- The SAM-e we offer is obtained naturally, by microbiological fermentation and without use of solvents. It is specially packaged to ensure optimal stability and biological activity.
Like SAM-e, other substances with excellent therapeutic potential are also available to buy as nutritional supplements. Super Quercetin, for example, is a quercetin concentrate with antioxidant, anti-inflammatory, anti-carcinogenic and cardio-protective properties. Two natural extracts also recognised for their therapeutic efficacy are French oak, for reducing fatigue and improving mood, and hypericum, for combatting mild to moderate depression.
Buy SAM-e to help with emotional well-being.
Alternative spelling/keywords: SAM e, SAMe, SAM_e, SAM
What is in SAM-e 400 mg
june 6 2025
Es bueno y hace lo que dice.
It's good and does what it says.
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march 19 2025
Man muß Geduld haben, bis eine spürbare Wirkung eintritt. Gutes Produkt.
You have to be patient until a noticeable effect occurs. Good product.
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march 13 2025
produit quasiment miraculeux pour réduire les douleurs
almost miraculous product for reducing pain
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february 6 2025
Ça fait 30 ans que je prends ce complément très bien je le conseille Fortement et ça du bien au moral et les articulations
I have been taking this supplement for 30 years, it's very good, I highly recommend it. It does wonders for morale and joints.
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december 27 2024
Nach dem SAMe von Puritan's Pride das Zweitbeste Produkt auf dem Markt
After Puritan's Pride SAMe, the second-best product on the market
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Bonjour Jean-Marc,
Merci d'avoir partagé votre avis sur notre SAM-e 400 mg - 60 comprimés gastro.
Il est vrai que les résultats peuvent varier selon les individus, et nous comprenons que cela puisse être frustrant. Si vous souhaitez discuter de vos préoccupations ou explorer d'autres options qui pourraient mieux répondre à vos besoins, n'hésitez pas à contacter notre service client. Nous sommes là pour vous aider.
Nous apprécions votre retour, qui nous aide à améliorer nos produits et services.
Cordialement,
Gaëlle - Supersmart