- The new, genetic cell detoxifier that could extend lifespan
- Acts to prevent the development of tumours and promote their regression.
Saikosaponin is a new genetic cell detoxifier that could extend lifespan by activating the P16 tumour-suppressing gene. Researchers are constantly and actively engaged in the quest to hold off the ravages of aging and extend human lifespan. The latest advances in genetics are generating significant new optimism1.
Scientists have made a genetic breakthrough which they say could extend human lifespan and even protect against cancer. Experiments on mice have shown that their lifespan could be prolonged by up to 45%, without developing cancerous tumours.
This suggests that under certain conditions, humans could live to almost 125 years, cancer-free, because the genes thought to be responsible are naturally present – and have identical roles - in both mice and humans. Geneticists and cancer experts have reached the same conclusions on the identification and role of these genes:
Manuel Serrano, a Spanish researcher at the CNIO, told a conference: “When P53 and P16 genes were activated in mice, cancer incidence was reduced to practically zero”. The Spanish scientists concluded that the activation of three genes – telomerase, P53 and the tumour-suppressor P16 – represented a major contribution to the prevention and regression of tumours by apoptosis (programmed cell death). They added: “We do not think that the mice lived longer because they didn't have cancer, but because these genes protected them against aging”.
This is therefore the first time that scientists have been able to prolong lifespan in mice in this way (by inserting an extra copy of the three genes), while protecting them from cancer. Until now, the mice were ageing without cancer, but their lifespan did not increase significantly. And only calorie restriction enabled their life expectancy to be extended. These transgenic mice, able to self-reproduce, have strengthened their new DNA model, thus creating a group of “supermice”, with longer lifespans of 4.5 years compared with the average 3 year lifespan, and that benefit from optimal protection against cancer.
Bupleurum falcatum or buplevre, belongs to the Apiacaeae plant family and is used in traditional Chinese and Japanese medicine. It is widely considered to be a cell detoxifier that helps fight chronic infection and inflammatory conditions (particularly hepatitis).
Bupleurum has recently increased in popularity due to favourable results achieved in cancer treatment. Its active principles are the saikosaponins A, B, C and D. Of these, it is the A form, a triterpenoid glycoside, that activates the tumour-suppressing P16 gene, but it is extremely rare and expensive - you would need to consume 50g of Bupleurum to obtain 4mg saikosaponin A. This new plant substance - saikosaponin A – has been specifically selected and isolated in order to activate the P16 tumour suppressor gene2.
A number of studies have demonstrated the immunosuppressive effects of saikosaponin A. It significantly inhibits the proliferation and activation of T cells and induces apoptosis of cancer cells via mitochondria, making it a potential treatment for inflammatory and auto-immune disease3, 4. One study combined saikosaponin A with astragaloside IV. It showed that treated mice lived significantly longer than controls, however advanced their tumours. The Chinese researchers also observed that mice with cancer whose diet had been supplemented with saikosaponin A lived longer than healthy mice. This encouraging animal research has already led to the development of human application treatments in the oncology departments of a number of Chinese hospitals.
The benefits of saikosoaponin A are enhanced when it is combined, though not simultaneously, with other anti-ageing substances. Supplementation with saikosaponin A is recommended on a non-continuous or alternating basis, ie, every other week, with astragaloside IV or cycloastragenol, which activate the telomerase gene, and with resveratrol and its derivatives, which activate the P53 gene. Though it is still too soon to establish a strict administration protocol for this product, the following can be used as a basis:
Caution: as saikosaponin A is a vasodilator, comparable to niacin, it should not be taken by anyone using coronary vasodilators, or by pregnant women or nursing mothers.
|Daily dose : 1 capsule
Number of doses per box : 15
|Amount per dose|
|Saikosaponin A||4 mg|
|Other ingredients: Acacia gum, rice flour.|
A research team has just found a way of reversing this loss of ability using a compound that promotes the growth of new blood vessels : NMN (nicotinamide mononucleotide).
There are many things you can do each day to put the brakes on ageing. Here are our ten top tips to help slow down the ageing process.
Diet, the impact of stress, possible causes of mutations, the processes involved … Two people discuss in depth the specifics of cancer.