GABA supplement, an inhibitory neurotransmitter
Gamma-amino-butyric acid, or GABA, is an essential molecule found naturally in the body. It is the main inhibitory neurotransmitter which means it plays an essential role in regulating neuron activity. In particular, it helps reduce excitation of nerve cells and prevent prolonged excitation. Alongside its essential role in neuron function, GABA supplement is also involved in promoting the development of certain neurons.
GABA, a key relaxing function
While some situations require neurons to be in an excitatory state, it is essential to be able to control this and restrict it to short periods. Excitation of neurons results in numerous effects in the body including raised blood pressure. Generally-speaking, significant neuron activity can manifest in anxiety or stress. In the brain, this is managed by maintaining a precise balance between inhibitory neurotransmitters such as GABA and those with an excitatory function, such as the amino acid glutamate; the effects of the latter need to be counterbalanced by those of GABA. In some people, however, there is an imbalance between GABA and glutamate which causes dysfunction in the body. It could, for example, be a factor in epileptic seizures or cerebral ischaemia – insufficient supply of oxygen to the brain.
Stress and anxiety, major threats to health
With its relaxing effect, GABA is an important source of natural stress relief. An increasing feature of modern society, stress describes the collection of responses made by the body to external pressures. There are many stress factors which can be perceived very differently from one individual to another. Though it can be positive, stress can also have negative consequences including agitation, irritation, worry, low mood, and muscle tension as well as digestive and breathing problems. Excessive stress levels lead to a state of anxiety which manifests in fear and worry. If this anxiety is not addressed, it can result in certain health problems such as depression or alcoholism. It is therefore vital to tackle these effects as soon as the first symptoms appear.
GABA’s sedative and anxiolytic effects
GABA’s potential for combatting stress and anxiety have made it the subject of numerous scientific studies, the results of which have highlighted its ability to reduce blood pressure in stressful situations. Researchers have also confirmed GABA’s sedative and anxiolytic effects at a cellular level which means it also offers relaxation, mood-enhancing and sleep-improving benefits. To combat the effects of stress and anxiety, it is important to maintain adequate GABA levels. Though it is naturally produced from glutamate in the body, levels of glutamate decline with age, and so too do those of GABA. This is why our dietary supplement has been specially formulated to provide 750mg of GABA per tablet, providing an optimal intake of this neurotransmitter, and an easy-to-take GABA dosage of one capsule a day, to be taken outside of mealtimes.
To help maintain general well-being, you may also be interested in neurotransmitter precursors such as and , amino acid derivatives.
You can find out more in our blog article: .
Muscle Relaxing Formula is a combination of plant extracts and micronutrients designed to provide immediate and long-lasting relief from muscle pain and discomfort. It’s a 100% natural formulation containing organically-grown plant extracts recognised for their efficacy against pain.
Who is Muscle Relaxing Formula aimed at?
This innovative formulation is for anyone affected by any of the following:
- frequent muscle pain;
- muscle pain that comes on after intensive exercise;
- involuntary muscle contractions of varying pain intensity; ;
- age-related night-time muscle stiffness ;
- muscle pain linked to nutrient deficiency (vitamin D, essential amino acids, testosterone);
- fibromyalgia pain ;
- muscle spasms ;
- pain from trauma;
- neuropathic pain of unknown origin ;
- other related problems: varicose veins, venous insufficiency, aches, elongation, tears, sprains…
What is in Muscle Relaxing Formula?
What is in Muscle Relaxing Formula?
Muscle Relaxing Formula combines the four plant extracts most widely-studied in relation to muscle pain – and in their best form.
Lemon balm leaf.
Lemon balm is a medicinal herb traditionally used for over 2000 years to calm the nerves and ease pain. Recent clinical trials have confirmed the anxiolytic effects of lemon balm extract (1-3) as well as its ability to reduce sensitivity to pain via modulation of certain receptors in the central nervous system (4-6). Studies have demonstrated its analgesic properties (7-8) and associated decrease in sensitivity to external stimuli (nociception).
These properties are linked to the presence of terpenes in its essential oil as well as to its high content of phenolic compounds (rosmarinic acid, caffeic acid), citral, flavonoids (luteolin) and tannins (9).
Attention: many unscrupulous manufacturers replace the costly lemon balm extract with related species that smell strongly of lemon such as citronella or lemongrass.
The aerial parts of passion flower.
Passion flower contains several substances that act as pain-relievers: indole alkaloids, flavonoids, terpenes and glucosides (10), although more than 294 volatile compounds have been identified.
The majority of pharmacological studies conducted on passion flower have demonstrated its effects on the central nervous system, particularly anxiolytic and sedative properties (11). Commission E (a European scientific advisory board) and ESCOP (the European Scientific Cooperative on Phytotherapy) also officially recognise the use of passion flower to reduce nervousness, and relieve muscle spasms and nerve pain.
The flowers of German camomile
Known for its relaxing properties, camomile has a number of anti-inflammatory and analgesic ingredients such as chamazulene, apigenin, flavonoids and alpha bisabolol. It has produced good results when administered to people suffering from various types of pain (12).
Attention: German camomile (Matricaria recutita), the flowers of which are the most beneficial parts, should not be confused with feverfew (Tanacetum parthenium), the leaves of which are used to reduce the intensity of headaches and migraines.
Traditionally used by Native Americans for treating muscle injuries, valerian root is still in demand today. It contains more than 150 chemical compounds, including valerenic acid and valtrates which explain its effect on certain chemical messengers in the brain and its relaxing benefits (13).
The formulation also contains two micronutrients recognised for their physiological benefits for human health:
Vitamin E (natural form).
Well-known for its exceptional antioxidant benefits, vitamin E also has anti-inflammatory and vasodilatory properties
Attention: the most abundant form in the body is alpha-tocopherol. As the synthetic form of this molecule is much less well-absorbed, it’s important to choose supplements such as Muscle Relaxing Formula which contain the natural form (14).
Magnesium (in its most soluble and absorbable form).
Magnesium plays a role in nerve transmission and helps muscles relax after contracting. As well as this muscle-relaxant effect, it also participates in pain relief: by disrupting NMDA receptors, it impedes the entry of calcium ions into cells, producing an anti-nociceptive effect.
This effect is associated with decreased sensitivity to pain stimuli triggered by injuries or insult to tissues. Magnesium thus offers significant potential for reducing hypersensitivity to actual and phantom pain.
Attention:The less absorbable a magnesium salt is, the less beneficial it will be for the body and the greater its laxative effect. It’s therefore essential to choose the best forms: magnesium citrate and magnesium chloride. It’s also important to control your magnesium intake from food if you are taking it in dietary supplement form.
Five good reasons to choose Muscle Relaxing Formula for fighting muscle pain:
- The six natural ingredients in Muscle Relaxing Formula have all been scientifically studied for their anti-inflammatory, analgesic or anti-nociceptive effects.
- Its plant extracts are all organically-produced. This is important as pesticides can be neurotoxic, potentially causing neurological dysfunction, exacerbating pain and promoting inflammation.
- Pain-killing drugs are currently claiming record numbers of victims: in 2017, more than 50,000 people died in the United States following side-effects from pain-killing drugs prescribed by their doctors. Thus an urgent return tonatural methods is called for.
In Europe and the US, more than one in two people currently suffer from joint or muscle pain . Such pain has a significant impact on sleep, level of physical activity and mood.
Muscle Relaxing Formula contains no chemical excipients.
Additional measures to make Muscle Relaxing Formula even more effective
To maximise this formulation’s efficacy, you can also follow these steps throughout the supplementation period:
1) Make sure you stay well-hydrated by drinking at least two litres of water a day, a little at a time. Good hydration promotes healthy circulation in muscle fibres.
2) Set aside time every day to relax (meditation, visualisation, listening to relaxing music, contemplation without stimuli, etc.) and ensure you get a good night’s sleep
3) Avoid eating foods that promote systemic inflammation such as red meat, dairy products, cooked meats, processed foods and refined cereals.
4) Prioritise anti-inflammatory foods, particularly those rich in omega-3 fatty acids (fats that are able to reduce pain) as well as fresh fruits and vegetables, all rich in antioxidants. You can combine Muscle Relaxing Formula with a daily dose of Super DHA, a natural formulation rich in omega-3 which provides a much higher intake than can be obtained from everyday diets.
Note: This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. Not recommended for women who are pregnant or breastfeeding, or for those with liver problems. This product may interfere with coagulants or blood pressure medication. Please consult a health professional before using if you are taking other medication or have any health problems. Do not take before driving or operating machinery. Keep out of children’s reach. Store in a cool, dry place.
Written: December 2018.
- Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66(4):607-13. Texte intégral : www.psychosomaticmedicine.org
- Kennedy DO, Scholey AB, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav. 2002 Jul;72(4):953-64.
- Santos-Neto LL, Toledo MAV, Medeiros-Souza P, Souza GA. The use of Herbal medicine in Alzheimer's disease — a sistematic review. Adv Acc Public 2006;23:441–5.
- Kennedy DO, Wake G, et al. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.
- Neuroprotective and neurological properties of Melissa officinalis. López V, Martín S, et al. Neurochem Res. 2009 Nov;34(11):1955-61.
- Pharmacological profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on ligand-gated channels. Abuhamdah S, Huang L, et al. J Pharm Pharmacol. 2008 Mar;60(3):377-84.
- Capasso R, Savino F, Capasso F. Effects of the herbal formulation ColiMil on upper gastrointestinal transit in mice in vivo. Phytother Res 2007;21:999-1101
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- Sasikala V, Saravanan S, Parimelazhagan T. Analgesic and anti-inflammatory activities of Passiflora foetida L. Asian Pacific Journal of Tropical Medicine (2011)600-603.
- Sharifi F, Simbar M, Mojab F, Majd HA. Comparison of the effects of Matricaria chamomila (Chamomile) extract and mefenamic acid on the intensity of premenstrual syndrome. Complement Ther Clin Pract. 2014 Feb;20(1):81-8. doi: 10.1016/j.ctcp.2013.09.002. Epub 2013 Oct 9.
- Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. Med Sci Monit. 2009 Nov;15(11):RA256-62.
- Institute of Medicine (IOM). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000) : Vitamin E., États-Unis, 2000.
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