- Contains all the non-psychotropic phytocannabinoids found in Cannabis sativa.
- Contains no psychotropic substances (THC).
- CBD oil effects include relief of inflammation and chronic pain.
CBD Oil 6 % is a supplement with non-psychotropic hemp oil standardised to 6.4% CBD, to provide an anti-inflammatory effect which helps with pain relief.
Cannabidiol (CBD) is a phytocannabinoid molecule found in hemp (Cannabis sativa), just like the well-known psychotropic substance, tetrahydrocannabinol (THC). However, unlike THC, CBD has no narcotic properties.
THC was the first psychoactive ingredient to be discovered in marijuana (1-3), but it was only in the 1990s that scientists identified the endogenous signalling system now known as the endocannabinoid system. This is a collection of endogenous messengers (endocannabinoids) and specific receptors located on external cell membranes (CB1 and CB2 receptors).
It works on a simple principle: when the body deems it necessary, endocannabinoid messengers are produced which bind to their corresponding receptors, triggering various cellular responses such as stimulation of appetite, limitation of synaptic transmission, anti-nociceptive effects (pain relief), hypothermia or reduction of spontaneous locomotion (4).
We know, for example, that endocannabinoids are effective at inhibiting the transmission of small-diameter nociceptive fibres (which are involved in the pain process) and at reducing the release of neurotransmitters such as substance P, which are responsible for the transmission of pain. What’s less straightforward is how this system influences several complex mechanisms such as neuroplasticity, apoptosis, neuroinflammation and traumatic memory.
It so happens that plants produce molecules that have a strong resemblance to endocannabinoids, so much so that they are able to bind to the same receptors (with varying degrees of affinity). Some of them, including THC, produce cellular responses which are very similar to – or even greater than - those triggered by endocannabinoids.
Cannabis contains more than 200 types of molecule that mimic endocannabinoids, including cannabidiol (CBD) which may account for up to 40% of the plant’s dry extract.
The CB1 and CB2 receptors to which endocannabinoids and phytocannabinoids bind are not randomly located in the body. They’re primarily found on the surface of cells of the human brain, central nervous system and immune system tissues. The hippocampus (particularly the dentate gyrus) as well as the Globus pallidus which controls movements (5) have a very high concentration of CB1 receptors, whereas immune tissue has a higher density of CB2 receptors (6). Their specific siting suggests that cannabinoids are involved in modulating memory, emotion, pain (chronic, inflammatory and neuropathic) (7-8) and movements (9-10).
CBD binds more to CB2 receptors, and THC to CB1 receptors. When CBD binds to its receptors, it triggers a chain reaction which results in a decrease in the release of neurotransmitters.
The binding of CBD to CB2 receptors appears primarily to reduce the inflammatory response. This involves multiple cellular targets and leads to a rise in BDNF (a protein that encourages the growth and differentiation of new neurons), a reduction in microglial cells and a fall in pro-inflammatory mediators (11-13). It is this anti-inflammatory effect which makes CBD so useful for pain relief.
CBD thus helps lower the production of inflammatory cytokines, maintain cerebral circulation during ischaemic events and reduce neuroinflammation (14). It also helps increase levels of adenosine in the brain which is associated with neuroprotection and decreased inflammation (15). In addition, it helps to activate PPARs (16), proteins that act as transcription factors of certain genes involved in inflammation and pain transmission.
Several studies have shown it to have additional benefits: it promotes vasodilation (17-18) and helps reduce reactive oxygen species (ROS) as well as lipid peroxidation (19-21). CBD is also involved in modulating receptors outside of the endocannabinoid system. For example, serotonin receptors also appear to play a part in CBD’s benefits and therapeutic properties.
CBD can reduce the intensity and impact of symptoms associated with chronic anxiety and stress (22-23). Human imaging has shown that CBD affects areas of the brain involved in the neurobiology of several psychiatric disorders. According to one study, a single dose of CBD administered orally to healthy volunteers altered resting activity in the limbic and paralimbic regions of the brain (24-25).
Research has also shown a potential reduction in memory associated with a traumatic experience.
The use of CBD oil for pain or anxiety is currently enjoying sustained popularity. Though media attention has played a substantial part in this, it is CBD’s properties and benefits, which are now well-documented, which are largely responsible for its success. Following is a summary of the properties variously demonstrated by in vitro, animal and clinical studies (26):
Following extraction, CBD is diluted in hemp seed oil.
Ordinarily, hemp seed oil contains very little CBD (0.0025%). CBD is mostly found in the flowers of Cannabis sativa and, to a lesser degree, the leaves, but not in the seeds. CBD Oil 6% therefore contains hemp seed oil to which CBD extracted from hemp flowers has been added.
When cannabis grows, it produces THC-A and CBD-A, not THC or CBD. It is only when the two molecules are heated that they are decarboxylated into their active forms (27). The conversion of CBD-A into CBD can also be achieved more slowly by exposing the molecule to light, to heat (the temperature of gastric fluids is 37°C) or overtime (28). CBD Oil 6% contains CBD and not CBD-A, as well as small amounts of a number of other phytocannabinoids. There is currently no product on the market offering greater CBD oil benefits.
The hemp used in this product contains no THC. It therefore has no narcotic effect and has an excellent safety profile in humans.
Once ingested, CBD is quickly distributed around the body. Its lipophilic nature means it rapidly crosses the blood-brain barrier to reach tissues in the brain. It does not alter the heart rate and affects neither blood pressure nor body temperature. The half-life of CBD is 9 hours, after which it is eliminated vie urine in a metabolised form.
Its softgel format and the fact that SuperSmart guarantees the purity of its ingredients means there are no particular contraindications associated with its use. To date, there have been no public health problems reported with the use of a THC-free hemp oil standardised in CBD.
CBD Oil 6% can be combined with other supplements available to buy at Supersmart such as InflaRelief Formula, an enhanced formulation for relief of inflammation problems, with Natural Pain Relief, a natural, universal painkiller, and with Posinol 50 mg, an extract of Apocynum venetum which promotes mental relaxation.
This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.
Buy CBD Oil 6% for pain relief.
|Daily dose: 2 softgels
Number of doses per pack: 15
|Cannabidiol (CBD) from 156.25mg of non-psychotropic hemp oil standardised to 6.4% CBD||10mg|
|No RDA established. Other ingredients: organic olive oil.|
Muscle Relaxing Formula is a combination of plant extracts and micronutrients designed to provide immediate and long-lasting relief from muscle pain and discomfort. It’s a 100% natural formulation delivered in vegetarian capsules,containing organically grown plant extracts recognised for their efficacy against pain, now available to buy at Supersmart.
This innovative formulation is for anyone affected by any of the following:
What is in Muscle Relaxing Formula?
Muscle Relaxing Formula combines the four plant extracts most widely-studied in relation to muscle pain – and in their best form.
Lemon balm is a medicinal herb traditionally used for over 2000 years to calm the nerves and ease pain. Recent clinical trials have confirmed the anxiolytic effects of lemon balm extract (1-3) as well as its ability to reduce sensitivity to pain via modulation of certain receptors in the central nervous system (4-6). Studies have demonstrated its analgesic properties (7-8) and associated decrease in sensitivity to external stimuli (nociception).
These properties are linked to the presence of terpenes in its essential oil as well as to its high content of phenolic compounds (rosmarinic acid, caffeic acid), citral, flavonoids (luteolin) and tannins (9).
Attention: many unscrupulous manufacturers replace the costly lemon balm extract with related species that smell strongly of lemon such as citronella or lemongrass.
Passionflower contains several substances that act as pain-relievers: indole alkaloids, flavonoids, terpenes and glucosides (10), although more than 294 volatile compounds have been identified.
The majority of pharmacological studies conducted on passionflower have demonstrated its effects on the central nervous system, particularly anxiolytic and sedative properties (11). Commission E (a European scientific advisory board) and ESCOP (the European Scientific Cooperative on Phytotherapy) also officially recognise the use of passionflower to reduce nervousness, and relieve muscle spasms and nerve pain.
Known for its relaxing properties, camomile has a number of anti-inflammatory and analgesic ingredients such as chamazulene, apigenin, flavonoids and alpha bisabolol. It has produced good results when administered to people suffering from various types of pain (12).
Attention: German camomile (Matricaria recutita), the flowers of which are the most beneficial parts, should not be confused with feverfew (Tanacetum parthenium), the leaves of which are used to reduce the intensity of headaches and migraines.
Traditionally used by Native Americans for treating muscle injuries, valerian root is still in demand today. It contains more than 150 chemical compounds, including valerenic acid and valtrates which explain its effect on certain chemical messengers in the brain and its relaxing benefits (13).
The formulation also contains two micronutrients recognised for their physiological benefits for human health:
Well-known for its exceptional antioxidant benefits, vitamin E also has anti-inflammatory and vasodilatory properties
Attention: the most abundant form in the body is alpha-tocopherol. As the synthetic form of this molecule is much less well-absorbed, it’s important to choose supplements such as Muscle Relaxing Formula which contain the natural form (14).
Magnesium plays a role in nerve transmission and helps muscles relax after contracting. As well as this muscle-relaxant effect, it also participates in pain relief: by disrupting NMDA receptors, it impedes the entry of calcium ions into cells, producing an anti-nociceptive effect.
This effect is associated with decreased sensitivity to pain stimuli triggered by injuries or insult to tissues. Magnesium thus offers significant potential for reducing hypersensitivity to actual and phantom pain.(15-16).
Attention: The less absorbable a magnesium salt is, the less beneficial it will be for the body and the greater its laxative effect. It’s therefore essential to choose the best forms: magnesium citrate and magnesium chloride. It’s also important to control your magnesium intake from food if you are taking it in dietary supplement form.
To maximise this formulation’s efficacy, you can also follow these steps throughout the supplementation period:
1) Make sure you stay well-hydrated by drinking at least two litres of water a day, a little at a time. Good hydration promotes healthy circulation in muscle fibres.
2) Set aside time every day to relax (meditation, visualisation, listening to relaxing music, contemplation without stimuli, etc.) and ensure you get a good night’s sleep overwork and lack of sleep exacerbate pain.
3) Avoid eating foods that promote systemic inflammation such as red meat, dairy products, cooked meats, processed foods and refined cereals.
4) Prioritise anti-inflammatory foods, particularly those rich in omega-3 fatty acids (fats that are able to reduce pain) as well as fresh fruits and vegetables, all rich in antioxidants. You can combine Muscle Relaxing Formula with a daily dose of Super DHA, a natural formulation rich in omega-3 which provides a much higher intake than can be obtained from everyday diets.
Note: This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. Not recommended for women who are pregnant or breastfeeding, or for those with liver problems. This product may interfere with coagulants or blood pressure medication. Please consult a health professional before using if you are taking other medication or have any health problems. Do not take before driving or operating machinery. Keep out of children’s reach. Store in a cool, dry place.
Buy Muscle Relaxing Formula Capsules to help relieve muscle pain.
Written: December 2018.
|Daily dose: 6 capsules
Number of doses per pack: 30
|Amount per daily dose||RDA|
|Extract of organically-grown valerian root.||600 mg||*|
|Extract of organically-grown lemon balm leaf.||350 mg||*|
|Extract of aerial part of organically-grown passion flower.||350 mg||*|
|Extract of organically-grown camomile flowers.||350 mg||*|
|Magnesium citrate||400 mg||12%|
|Calcium citrate||100 mg||3%|
|Natural-source vitamin E (d-alpha-tocopherol).||100 IU||558%|
|Other ingredients: acacia gum.
*Recommended daily amount not defined.
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