- Contains all the non-psychotropic phytocannabinoids found in Cannabis sativa.
- Contains no psychotropic substances (THC).
- CBD oil effects include relief of inflammation and chronic pain.
CBD Oil 6 % is a supplement with non-psychotropic hemp oil standardised to 6.4% CBD, to provide an anti-inflammatory effect which helps with pain relief.
The CB1 and CB2 receptors to which endocannabinoids and phytocannabinoids bind are not randomly located in the body. They’re primarily found on the surface of cells of the human brain, central nervous system and immune system tissues. The hippocampus (particularly the dentate gyrus) as well as the Globus pallidus which controls movements (5) have a very high concentration of CB1 receptors, whereas immune tissue has a higher density of CB2 receptors (6). Their specific siting suggests that cannabinoids are involved in modulating memory, emotion, pain (chronic, inflammatory and neuropathic) (7-8) and movements (9-10).
CBD binds more to CB2 receptors, and THC to CB1 receptors. When CBD binds to its receptors, it triggers a chain reaction which results in a decrease in the release of neurotransmitters.
The binding of CBD to CB2 receptors appears primarily to reduce the inflammatory response. This involves multiple cellular targets and leads to a rise in BDNF (a protein that encourages the growth and differentiation of new neurons), a reduction in microglial cells and a fall in pro-inflammatory mediators (11-13). It is this anti-inflammatory effect which makes CBD so useful for pain relief.
CBD thus helps lower the production of inflammatory cytokines, maintain cerebral circulation during ischaemic events and reduce neuroinflammation (14). It also helps increase levels of adenosine in the brain which is associated with neuroprotection and decreased inflammation (15). In addition, it helps to activate PPARs (16), proteins that act as transcription factors of certain genes involved in inflammation and pain transmission.
Several studies have shown it to have additional benefits: it promotes vasodilation (17-18) and helps reduce reactive oxygen species (ROS) as well as lipid peroxidation (19-21). CBD is also involved in modulating receptors outside of the endocannabinoid system. For example, serotonin receptors also appear to play a part in CBD’s benefits and therapeutic properties.
CBD can reduce the intensity and impact of symptoms associated with chronic anxiety and stress (22-23). Human imaging has shown that CBD affects areas of the brain involved in the neurobiology of several psychiatric disorders. According to one study, a single dose of CBD administered orally to healthy volunteers altered resting activity in the limbic and paralimbic regions of the brain (24-25).
Research has also shown a potential reduction in memory associated with a traumatic experience.
The use of CBD oil for pain or anxiety is currently enjoying sustained popularity. Though media attention has played a substantial part in this, it is CBD’s properties and benefits, which are now well-documented, which are largely responsible for its success. Following is a summary of the properties variously demonstrated by in vitro, animal and clinical studies (26):
Buy CBD Oil 6% for pain relief.
Daily dose: 2 softgels Number of doses per pack: 15 |
Amount |
Cannabidiol (CBD) from 156.25mg of non-psychotropic hemp oil standardised to 6.4% CBD | 10mg |
No RDA established. Other ingredients: organic olive oil. |
Muscle Relaxing Formula is a combination of plant extracts and micronutrients designed to provide immediate and long-lasting relief from muscle pain and discomfort. It’s a 100% natural formulation delivered in vegetarian capsules,containing organically grown plant extracts recognised for their efficacy against pain, now available to buy at Supersmart.
This innovative formulation is for anyone affected by any of the following:
Daily dose: 6 capsules
Number of doses per pack: 30 |
Amount per daily dose | RDA |
Extract of organically-grown valerian root. | 600 mg | * |
Extract of organically-grown lemon balm leaf. | 350 mg | * |
Extract of aerial part of organically-grown passion flower. | 350 mg | * |
Extract of organically-grown camomile flowers. | 350 mg | * |
Magnesium citrate | 400 mg | 12% |
Calcium citrate | 100 mg | 3% |
Natural-source vitamin E (d-alpha-tocopherol). | 100 IU | 558% |
Other ingredients: acacia gum.
*Recommended daily amount not defined. |
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