0
en
US
SuperSmartSuper-nutrition Blog
X
× Shop by health concern Shop by product Bestsellers New products Promotions My account Smart Prescription Blog Loyalty scheme Language: English
Welcome Shop by health concern Stress and mood SAM-e 400 mg
SAM-e 400 mg
SAM-e 400 mg SAM-e 400 mg
SAM-e 400 mg
Stress and mood Customer reviews
99.00 €(109.20 US$) Limited quantity
Description
SAM-e supplement:
  • essential role in cycle of glutathione, a powerful antioxidant produced by the body;
  • effective at treating depression;
  • as effective as conventional anti-inflammatories for treating arthritis, with no unwelcome side-effects.
  • -
    +
    60 enteric coated tablets
    Add to basket Certificate of Analysis
    Wish list
    Tired middle-aged woman, supporting her head with her hand with her eyes closed.

    SAM-e 400 mg | S-adenosyl-methionine Supplement

    S-adenosyl-methionine (SAM-e) is a naturally-occuring compound in the body which promotes methylation, the process whereby methyl groups (one atom of carbon and 3 of hydrogen) are transferred from one molecule to another. Methylation is essential for many enzymatic processes and SAM-e is the most active of all methyl donors. Indeed, SAM-e has been the subject of dozens of clinical studies involving thousands of patients.

    What are the benefits associated with SAM-e?

    SAM-e plays a crucial role in conjunctive tissue synthesis; it eases joint pain, promotes mobility and protects cartilage from damage. In 2002, an American government agency, the Agency for Healthcare Research and Quality (AHRQ) concluded that SAM-e was 80% more effective than a placebo at relieving osteo-arthritis pain, and as effective as non-steroidal anti-inflammatories (NSAIDs) at treating osteo-arthritis. NSAIDs are associated with serious side-effects while SAM-e has health benefits for the whole body:

    • SAM-e supports hepatic synthesis of glutathione, an essential antioxidant. It stimulates the detoxification and regeneration of the liver. It has been used for treating cirrhosis and for helping people to give up alcohol and drugs.
    • SAM-e helps treat depression naturally, more effectively and faster than anti-depressants, and without any side-effects. It simultaneously increases levels of several neurotransmitters - deficient in patients being treated for depression.
    • The methylation promoted by SAM-e is a key element of the energy production process, particularly the recycling of adenosine triphosphate (ATP). SAM-e has a beneficial effect on the mechanisms of ageing by protecting desoxyribonucleic acid (DNA) from demethylation.
    • SAM-e may also prevent cerebral ageing: in a recent animal study, SAM-e doubled glutathione levels in the brain and increased levels of its enzymatic metabolites by 98%. It decreased a marker of radical activity by 46%, and in culture, reduced lipid peroxidation by 55%. It is a powerful and pluripotent nutrient which can be life-changing when taken at sufficient levels and in the right form.

    Why is SAM-e 400 mg supplement a better option?

    We introduced SAM-e into Europe in 1998 and while its price has now been reduced by over 70%, it remains an expensive nutrient. It should be recognized that:

    1. SAM-e is a chiral molecule which exists in two forms: an active isomer (S,S) and an inactive isomer (R, S). All SAM-e products contain these two isomers in varying percentages. The SAM-e that we offer contains 70-80% of the (S,S) form which is the highest level available in a pharmaceutical grade product. Some (too) cheap products contain just 47% or less.
    2. SAM-e is a highly-reactive and therefore very fragile molecule which degrades rapidly when subjected to heat, humidity or gastric acids. In fact, a poorly packaged SAM-e product will degrade in just a few hours, resulting in a total lack of biological activity. In order to preserve SAM-e from heat and humidity, it is essential that each tablet is double foil blister-packed. To protect it from gastric acids, it must be enteric-coated: pharmacokinetic studies show that this results in maximum serum levels. This type of packaging is more expensive but it is quite simply essential.
    3. The SAM-e we offer is obtained naturally, by microbiological fermentation and without use of solvents. It is specially packaged to ensure optimal stability and biological activity.

    Like SAM-e, other substances with excellent therapeutic potential are also available as nutritional supplements. Super Quercetin, for example, is a quercetin concentrate with antioxidant, anti-inflammatory, anti-carcinogenic and cardio-protective properties. Two natural extracts also recognised for their therapeutic efficacy are French oak, for reducing fatigue and improving mood, and hypericum, for combatting mild to moderate depression.

    Alternative spelling/keywords : SAM e, SAMe, SAM_e, SAM

    Composition
    Daily serving: 2 tablets
    Number of servings per bottle: 30
    Quantity per serving
    Elemental S-Adenosyl Methionine (obtained from 1 600 mg of S-Adenosyl L-Methionine-disulfate p-toluenesulfonate) 800 mg
    Other ingredients: Microcrystalline cellulose, magnesium hydroxide, stearic acid, anhydrous calcium chloride, magnesium stearate, colloidal anhydrous silicon, calcium oxide, talc, shellac, arginine base, glycerol, silicon dioxide, sodium alginate.

    Each gastroresistant tablet provides 400 mg of elemental S-Adenosyl Methionine.
    Directions for use
    Take 400 to 800 mg a day on an empty stomach, as required or as advised by your therapist. For preventative use, take 200 to 400 mg a day. This product is suitable for vegetarians. Taking SAM-e is not advised for those who are on antidepressants, or who have Parkinson's disease or bipolar disorders. In these cases, please consult your therapist.

    Featured products

    New
    Daily 3®Daily 3®

    The most complete multivitamin supplement you can take in a single capsule

    49.00 €(54.05 US$)
    +
    Lactobacillus gasseriLactobacillus gasseri

    A probiotic strain that’s particularly effective for weight control In gastroresistant DR Caps™ for optimum efficacy.

    21.00 €(23.16 US$)
    +
    New
    CBD 25 mgCBD 25 mg

    Natural, powerful analgesic for long-lasting pain relief

    63.00 €(69.49 US$)
    +
    Melatonin Spray 1 mgMelatonin Spray 1 mg

    All the efficacy of prolonged-release melatonin in a convenient, metered-dose, sublingual spray.

    18.00 €(19.85 US$)
    +
    Berberine 500 mgBerberine 500 mg

    A natural and powerful new weapon against type II diabetes

    32.00 €(35.30 US$)
    +
    New
    Senolytic ComplexSenolytic Complex

    Senolytics: a revolutionary formula for destroying the senescent cells responsible for aging

    84.00 €(92.65 US$)
    +
    Vitamin D3 5000 IUVitamin D3 5000 IU

    To help prevent the risks of vitamin D deficiency Fat-soluble vitamin in oil form = increased bioavailability

    18.00 €(19.85 US$)
    +
    Super Omega 3 - 500 mgSuper Omega 3 - 500 mg

    EPA and DHA: one of the most natural, pure, powerful and stable product on the market

    25.00 €(27.57 US$)
    +
    Super Curcuma 500 mgSuper Curcuma 500 mg

    Curcuma phytosomes with higher bioavailability New patented curcuma extract, 29 times more bioavailable !

    45.00 €(49.63 US$)
    +
    Smart PillsSmart Pills

    An exceptional formulation for stimulating the brain (nootropic)

    32.98 €(36.38 US$)
    +
    AntiOxidant SynergyAntiOxidant Synergy

    Powerful, multi-action antioxidant defence

    43.00 €(47.43 US$)
    +
    Subscribe to our newsletter
    and obtain a 5% permanent discount
    Our selection of articles
    Stress: the best ways to eliminate it!

    If, after trying everything, stress still seems to be blighting your life, fear not. Here are some truly effective methods for relieving stress and ensuring you maintain a positive outlook. Keep calm and carry on!

    The neurotransmitter GABA: a natural stress-buster

    Everything you need to know about natural GABA: its characteristics, mechanism of action, properties, benefits, uses, latest research and scientific opinion …

    MSM: the benefits of organic sulphur!

    The experts at SuperSmart have put together the following guide which contains everything you need to know about MSM: its characteristics, properties, benefits, uses, doses and scientific opinion …

    SAM-e 400 mg
    -
    +
    99.00 €
    (109.20 US$)
    Add to basket
    © 1997-2019 Supersmart.com® - All rights reserved
    © 1997-2019 Supersmart.com®
    All rights reserved
    x
    secure