- Stimulates the repair of DNA damage by activating telomerase.
- Curtails shortening of telomeres and even increases their numbers.
- Traditionally used as an immunostimulant for its ability to increase T lymphocyte proliferation.
Cycloastragenol has a similar chemical structure to that of the Astragaloside IV molecule, but it is smaller and significantly more bioavailable, enabling lower doses to be taken. It is already used as an immunostimulant because of its ability to increase T lymphocyte proliferation. However, it is its exceptional anti-ageing benefits that are of increasing interest to the scientific community.
Cycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is extracted and purified from the root of the plant Astragalus membranaceus, which has been used in Chinese pharmacopoeia for thousands of years, particularly for its ability to slow down age-related degenerative processes. However, cycloastragenol is present in astragalus in minute quantities and extracting it is a highly complex and costly business.
Cycloastragenol stimulates the repair of DNA damage by activating telomerase, a nucleoprotein enzyme which catalyses synthesis and growth of telomeric DNA. Telomeres are made of thin filaments and are found at the tips of chromosomes. Maintaining their stability enables cells to avoid replicative senescence and indefinite proliferation beyond the 'Hayflick limit'. Telomeres shorten with each cycle of cell division, or when subjected to oxidative stress. Until now, this has been an unavoidable mechanism of ageing.
Stimulating telomerase and increasing telomeres are without doubt the most promising ways of increasing life expectancy naturally. Animal and in vivo tests show that cycloastragenol is one of the very few substances - and the most powerful - that can appreciably increase such activity.
Recent studies have shown that shortened telomeres are responsible for a number of age-related diseases and are also predictive of premature death in elderly subjects. This has been confirmed by examining the immune response of T lymphocytes in terminal-phase infection, the T lymphocytes having significantly shortened telomeres. The study showed a noticeable fall in immune function and increased secretion of various cytokine-related pro-inflammatory factors. In contrast, maintaining a high telomerase level, whether through genetic manipulation or through the introduction of activating substances (such as cycloastragenol), curtails shortening of telomeres and even increases their numbers, restoring a more youthful T lymphocyte profile.
The efficacy of cycloastragenol appears to be dose-dependent and people with the shortest telomeres – often the oldest members of society – achieve better and faster results with higher doses, from between 25mg to even 50mg a day. This new formulation provides 25 mg capsules, which is the required dose at a 20% lower cost, milligram for milligram. Cycloastragenol can be combined with the anti-ageing supplement Astragaloside IV, available to buy at Supersmart, to provide a wider spectrum of activity, or it can be alternated with it.
Buy Cycloastragenol Maximum Strenght capsules to stimulate telomerase.
|Daily dose : 1 capsule
Number of doses per box : 60
|Amount per dose|
|Cycloastragenol 98%||25 mg|
|Other ingredients: Acacia gum, rice flour.|
The polyphenol content of fruits and vegetables is one of the main reasons these foods are so good for our health. But which contain the most? And can you guess which one takes the no. 1 spot?
Glycation is a silent but powerful chemical reaction that plays a key role in the aging process. Find out exactly what’s involved in this ‘spontaneous caramelisation’ of the body, and how to curb it.
Antioxidants have been very popular for several years because of their ability, real or perceived, to help fight against ageing. But which of them offers the greatest potency?